Literature DB >> 21873425

Taurine-containing uridine modifications in tRNA anticodons are required to decipher non-universal genetic codes in ascidian mitochondria.

Takeo Suzuki1, Kenjyo Miyauchi, Tsutomu Suzuki, Shin-ichi Yokobori, Naoki Shigi, Akiko Kondow, Nono Takeuchi, Akihiko Yamagishi, Kimitsuna Watanabe.   

Abstract

Variations in the genetic code are found frequently in mitochondrial decoding systems. Four non-universal genetic codes are employed in ascidian mitochondria: AUA for Met, UGA for Trp, and AGA/AGG(AGR) for Gly. To clarify the decoding mechanism for the non-universal genetic codes, we isolated and analyzed mitochondrial tRNAs for Trp, Met, and Gly from an ascidian, Halocynthia roretzi. Mass spectrometric analysis identified 5-taurinomethyluridine (τm(5)U) at the anticodon wobble positions of tRNA(Met)(AUR), tRNA(Trp)(UGR), and tRNA(Gly)(AGR), suggesting that τm(5)U plays a critical role in the accurate deciphering of all four non-universal codes by preventing the misreading of pyrimidine-ending near-cognate codons (NNY) in their respective family boxes. Acquisition of the wobble modification appears to be a prerequisite for the genetic code alteration.

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Year:  2011        PMID： 21873425      PMCID： PMC3195572          DOI： 10.1074/jbc.M111.279810

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  43 in total

1.  Complete DNA sequence of the mitochondrial genome of the ascidian Halocynthia roretzi (Chordata, Urochordata).

Authors:  S i Yokobori; T Ueda; G Feldmaier-Fuchs; S Pääbo; R Ueshima; A Kondow; K Nishikawa; K Watanabe
Journal:  Genetics       Date:  1999-12       Impact factor: 4.562

Review 2.  Human mitochondrial diseases caused by lack of taurine modification in mitochondrial tRNAs.

Authors:  Tsutomu Suzuki; Asuteka Nagao; Takeo Suzuki
Journal:  Wiley Interdiscip Rev RNA       Date:  2011-02-25       Impact factor: 9.957

3.  Unusual usage of wobble modifications in mitochondrial tRNAs of the nematode Ascaris suum.

Authors:  Masayuki Sakurai; Takashi Ohtsuki; Tsutomu Suzuki; Kimitsuna Watanabe
Journal:  FEBS Lett       Date:  2005-04-20       Impact factor: 4.124

Review 4.  Initiator transfer RNAs.

Authors:  U L RajBhandary
Journal:  J Bacteriol       Date:  1994-02       Impact factor: 3.490

5.  Platyhelminth mitochondrial DNA: evidence for early evolutionary origin of a tRNA(serAGN) that contains a dihydrouridine arm replacement loop, and of serine-specifying AGA and AGG codons.

Authors:  J R Garey; D R Wolstenholme
Journal:  J Mol Evol       Date:  1989-05       Impact factor: 2.395

6.  Large scale isolation and some properties of AGY-specific serine tRNA from bovine heart mitochondria.

Authors:  T Ueda; T Ohta; K Watanabe
Journal:  J Biochem       Date:  1985-11       Impact factor: 3.387

7.  Sequence and organization of the human mitochondrial genome.

Authors:  S Anderson; A T Bankier; B G Barrell; M H de Bruijn; A R Coulson; J Drouin; I C Eperon; D P Nierlich; B A Roe; F Sanger; P H Schreier; A J Smith; R Staden; I G Young
Journal:  Nature       Date:  1981-04-09       Impact factor: 49.962

8.  Initiation of protein synthesis in animal mitochondria. Purification and characterization of translational initiation factor 2.

Authors:  H X Liao; L L Spremulli
Journal:  J Biol Chem       Date:  1991-11-05       Impact factor: 5.157

9.  tRNA Modification and Genetic Code Variations in Animal Mitochondria.

Authors:  Kimitsuna Watanabe; Shin-Ichi Yokobori
Journal:  J Nucleic Acids       Date:  2011-10-09

10.  Automated parallel isolation of multiple species of non-coding RNAs by the reciprocal circulating chromatography method.

Authors:  Kenjyo Miyauchi; Tomoya Ohara; Tsutomu Suzuki
Journal:  Nucleic Acids Res       Date:  2007-01-23       Impact factor: 16.971
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  12 in total

Review 1.  Distribution and frequencies of post-transcriptional modifications in tRNAs.

Authors:  Magdalena A Machnicka; Anna Olchowik; Henri Grosjean; Janusz M Bujnicki
Journal:  RNA Biol       Date:  2014       Impact factor: 4.652

2.  Decoding mechanism of non-universal genetic codes in Loligo bleekeri mitochondria.

Authors:  Takayuki Ohira; Takeo Suzuki; Kenjyo Miyauchi; Tsutomu Suzuki; Shin-ichi Yokobori; Akihiko Yamagishi; Kimitsuna Watanabe
Journal:  J Biol Chem       Date:  2013-01-28       Impact factor: 5.157

3.  LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs.

Authors:  Benedetta Ruzzenente; Metodi D Metodiev; Anna Wredenberg; Ana Bratic; Chan Bae Park; Yolanda Cámara; Dusanka Milenkovic; Volker Zickermann; Rolf Wibom; Kjell Hultenby; Hediye Erdjument-Bromage; Paul Tempst; Ulrich Brandt; James B Stewart; Claes M Gustafsson; Nils-Göran Larsson
Journal:  EMBO J       Date:  2011-11-01       Impact factor: 11.598

Review 4.  The central role of tRNA in genetic code expansion.

Authors:  Noah M Reynolds; Oscar Vargas-Rodriguez; Dieter Söll; Ana Crnković
Journal:  Biochim Biophys Acta Gen Subj       Date:  2017-03-18       Impact factor: 3.770

5.  tRNA Modification and Genetic Code Variations in Animal Mitochondria.

Authors:  Kimitsuna Watanabe; Shin-Ichi Yokobori
Journal:  J Nucleic Acids       Date:  2011-10-09

Review 6.  Reactive oxygen species, apoptosis, and mitochondrial dysfunction in hearing loss.

Authors:  Teru Kamogashira; Chisato Fujimoto; Tatsuya Yamasoba
Journal:  Biomed Res Int       Date:  2015-03-22       Impact factor: 3.411

Review 7.  Methylated nucleosides in tRNA and tRNA methyltransferases.

Authors:  Hiroyuki Hori
Journal:  Front Genet       Date:  2014-05-23       Impact factor: 4.599

Review 8.  tRNA biology in mitochondria.

Authors:  Thalia Salinas-Giegé; Richard Giegé; Philippe Giegé
Journal:  Int J Mol Sci       Date:  2015-02-27       Impact factor: 5.923

Review 9.  Non-Standard Genetic Codes Define New Concepts for Protein Engineering.

Authors:  Ana R Bezerra; Ana R Guimarães; Manuel A S Santos
Journal:  Life (Basel)       Date:  2015-11-12

Review 10.  An integrated, structure- and energy-based view of the genetic code.

Authors:  Henri Grosjean; Eric Westhof
Journal:  Nucleic Acids Res       Date:  2016-07-22       Impact factor: 16.971
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