Literature DB >> 15907479

Unusual usage of wobble modifications in mitochondrial tRNAs of the nematode Ascaris suum.

Masayuki Sakurai1, Takashi Ohtsuki, Tsutomu Suzuki, Kimitsuna Watanabe.   

Abstract

To understand the decoding property of nematode mitochondrial tRNAs with unusual secondary structures, post-transcriptional modifications at wobble positions of Ascaris suum mitochondrial tRNAs corresponding to two-codon families ending with a purine were analyzed. 5-Carboxymethylaminomethyluridine (cmnm(5)U) was identified at the wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln), while 5-carboxymethylaminomethyl-2-thiouridine (cmnm(5)s(2)U) was present in tRNA(UAA)(Leu)andtRNA(Trp). In most bacterial and mitochondrial tRNAs, the 2-thiouridine derivative is present in tRNAs for Lys, Glu and Gln. These is no report that cmnm(5)s(2)U is used in tRNA(UAA)(Leu)andtRNA(Trp). The unusual usage of wobble modifications might assist decoding of nematode mitochondrial mRNAs.

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Year:  2005        PMID： 15907479     DOI： 10.1016/j.febslet.2005.04.009

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  13 in total

1.  Taurine-containing uridine modifications in tRNA anticodons are required to decipher non-universal genetic codes in ascidian mitochondria.

Authors:  Takeo Suzuki; Kenjyo Miyauchi; Tsutomu Suzuki; Shin-ichi Yokobori; Naoki Shigi; Akiko Kondow; Nono Takeuchi; Akihiko Yamagishi; Kimitsuna Watanabe
Journal:  J Biol Chem       Date:  2011-08-26       Impact factor: 5.157

2.  Decoding mechanism of non-universal genetic codes in Loligo bleekeri mitochondria.

Authors:  Takayuki Ohira; Takeo Suzuki; Kenjyo Miyauchi; Tsutomu Suzuki; Shin-ichi Yokobori; Akihiko Yamagishi; Kimitsuna Watanabe
Journal:  J Biol Chem       Date:  2013-01-28       Impact factor: 5.157

3.  Inosine cyanoethylation identifies A-to-I RNA editing sites in the human transcriptome.

Authors:  Masayuki Sakurai; Takanori Yano; Hitomi Kawabata; Hiroki Ueda; Tsutomu Suzuki
Journal:  Nat Chem Biol       Date:  2010-09-12       Impact factor: 15.040

4.  Structural and mechanistic basis for enhanced translational efficiency by 2-thiouridine at the tRNA anticodon wobble position.

Authors:  Annia Rodriguez-Hernandez; Jessica L Spears; Kirk W Gaston; Patrick A Limbach; Howard Gamper; Ya-Ming Hou; Rob Kaiser; Paul F Agris; John J Perona
Journal:  J Mol Biol       Date:  2013-05-28       Impact factor: 5.469

5.  The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA.

Authors:  Veronika Reiter; Dorothea M S Matschkal; Mirko Wagner; Daniel Globisch; Andrea C Kneuttinger; Markus Müller; Thomas Carell
Journal:  Nucleic Acids Res       Date:  2012-03-15       Impact factor: 16.971

Review 6.  Early days of tRNA research: discovery, function, purification and sequence analysis.

Authors:  Uttam L RajBhandary; Caroline Köhrer
Journal:  J Biosci       Date:  2006-10       Impact factor: 2.795

7.  tRNA Modification and Genetic Code Variations in Animal Mitochondria.

Authors:  Kimitsuna Watanabe; Shin-Ichi Yokobori
Journal:  J Nucleic Acids       Date:  2011-10-09

Review 8.  Methylated nucleosides in tRNA and tRNA methyltransferases.

Authors:  Hiroyuki Hori
Journal:  Front Genet       Date:  2014-05-23       Impact factor: 4.599

Review 9.  Unique features of animal mitochondrial translation systems. The non-universal genetic code, unusual features of the translational apparatus and their relevance to human mitochondrial diseases.

Authors:  Kimitsuna Watanabe
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2010       Impact factor: 3.493

Review 10.  Losing the stem-loop structure from metazoan mitochondrial tRNAs and co-evolution of interacting factors.

Authors:  Yoh-Ichi Watanabe; Takuma Suematsu; Takashi Ohtsuki
Journal:  Front Genet       Date:  2014-05-01       Impact factor: 4.599
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