| Literature DB >> 21857657 |
Rikako Sanuki1, Akishi Onishi, Chieko Koike, Rieko Muramatsu, Satoshi Watanabe, Yuki Muranishi, Shoichi Irie, Shinji Uneo, Toshiyuki Koyasu, Ryosuke Matsui, Yoan Chérasse, Yoshihiro Urade, Dai Watanabe, Mineo Kondo, Toshihide Yamashita, Takahisa Furukawa.
Abstract
MicroRNA-124a (miR-124a) is the most abundant microRNA expressed in the vertebrate CNS. Despite past investigations into the role of miR-124a, inconsistent results have left the in vivo function of miR-124a unclear. We examined the in vivo function of miR-124a by targeted disruption of Rncr3 (retinal non-coding RNA 3), the dominant source of miR-124a. Rncr3(-/-) mice exhibited abnormalities in the CNS, including small brain size, axonal mis-sprouting of dentate gyrus granule cells and retinal cone cell death. We found that Lhx2 is an in vivo target mRNA of miR-124a. We also observed that LHX2 downregulation by miR-124a is required for the prevention of apoptosis in the developing retina and proper axonal development of hippocampal neurons. These results suggest that miR-124a is essential for the maturation and survival of dentate gyrus neurons and retinal cones, as it represses Lhx2 translation.Entities:
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Year: 2011 PMID： 21857657 DOI： 10.1038/nn.2897
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884