PURPOSE: To determine whether waist circumference (WC) is a better predictor of insulin resistance (IR) than body mass index (BMI) in U.S. adolescents aged 12-18 years. METHODS: Using data from the National Health and Nutrition Examination Survey 1999-2002, we evaluated an ethnically diverse sample of 1,571 adolescents with regard to BMI, WC, and fasting glucose and insulin levels. Children were classified as having IR if they had a homeostasis model assessment of insulin resistance (insulin [U/mL] × glucose [mmol/L]/22.5) of greater than 4.39.We created receiver operating characteristic curves predicting IR across various thresholds of WC and BMI, and area under the curve was compared. RESULTS: The prevalence rate of IR in the study population was 11.8%. Measures of test performance (sensitivity and specificity) for predicting IR were similar for abnormal BMI and WC thresholds; that is, thresholds of BMI 85th% and WC 75th% and thresholds of BMI 95th% and WC 90th% were quite similar. There were no significant differences in area under the curve for WC versus BMI (.85; 95% CI, .83-.88; p = .84) either for the overall population or for specific racial groups. CONCLUSIONS: WC does not seem to provide a distinct advantage over BMI for identifying adolescents with IR.
PURPOSE: To determine whether waist circumference (WC) is a better predictor of insulin resistance (IR) than body mass index (BMI) in U.S. adolescents aged 12-18 years. METHODS: Using data from the National Health and Nutrition Examination Survey 1999-2002, we evaluated an ethnically diverse sample of 1,571 adolescents with regard to BMI, WC, and fasting glucose and insulin levels. Children were classified as having IR if they had a homeostasis model assessment of insulin resistance (insulin [U/mL] × glucose [mmol/L]/22.5) of greater than 4.39.We created receiver operating characteristic curves predicting IR across various thresholds of WC and BMI, and area under the curve was compared. RESULTS: The prevalence rate of IR in the study population was 11.8%. Measures of test performance (sensitivity and specificity) for predicting IR were similar for abnormal BMI and WC thresholds; that is, thresholds of BMI 85th% and WC 75th% and thresholds of BMI 95th% and WC 90th% were quite similar. There were no significant differences in area under the curve for WC versus BMI (.85; 95% CI, .83-.88; p = .84) either for the overall population or for specific racial groups. CONCLUSIONS: WC does not seem to provide a distinct advantage over BMI for identifying adolescents with IR.
Authors: Nancy F Krebs; John H Himes; Dawn Jacobson; Theresa A Nicklas; Patricia Guilday; Dennis Styne Journal: Pediatrics Date: 2007-12 Impact factor: 7.124
Authors: Peter M Wolfgram; Ellen L Connor; Jennifer L Rehm; Jens C Eickhoff; Wei Zha; Scott B Reeder; David B Allen Journal: Horm Res Paediatr Date: 2015-09-10 Impact factor: 2.852
Authors: Qibin Qi; Simin Hua; Krista M Perreira; Jianwen Cai; Linda Van Horn; Neil Schneiderman; Bharat Thyagarajan; Alan M Delamater; Robert C Kaplan; Carmen R Isasi Journal: J Clin Endocrinol Metab Date: 2017-01-01 Impact factor: 5.958
Authors: Ana Paula Grotti Clemente; Bárbara Dal Molin Netto; Joana Pereira de Carvalho-Ferreira; Raquel Munhoz da Silveira Campos; Aline de Piano Ganen; Lian Tock; Marco Túlio de Mello; Ana Raimunda Dâmaso Journal: Rev Paul Pediatr Date: 2015-12-31