Neslihan Gungor1, Rola Saad, Janine Janosky, Silva Arslanian. 1. Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.
Abstract
OBJECTIVES: To compare insulin sensitivity and pancreatic beta-cell function measured by the euglycemic and the hyperglycemic clamp, with simple estimates of insulin sensitivity and pancreatic beta-cell function in youth. Study design We measured insulin sensitivity with a euglycemic clamp and first- and second-phase insulin secretion with a hyperglycemic clamp in 156 AA and white youths. Estimates of insulin sensitivity (fasting insulin level [I(F)], the ratio of fasting glucose [G(F)] to I(F) [G(F)/I(F)], homeostasis model assessment estimate of insulin sensitivity [HOMA IS], and quantitative insulin sensitivity check index [QUICKI]) and estimates of pancreatic beta-cell function (I(F), the ratio of I(F) to G(F) [I(F)/G(F)], and homeostasis model assessment estimate of pancreatic beta-cell function [HOMA %B]) were derived from fasting measurements. RESULTS: In the total group, IS(Eu) correlated strongly with I(F) (r=-0.92), G(F)/I(F) (r=0.92), HOMA IS (r=0.91), and QUICKI (r=0.91) (P<.01). First-phase and second-phase insulin secretion correlated with I(F), I(F)/G(F), and HOMA %B (first-phase insulin secretion: r=0.76, 0.79, 0.82; second-phase insulin secretion: r=0.83, 0.86, 0.86, respectively; P<.01). CONCLUSIONS: Simple estimates of insulin sensitivity and pancreatic beta-cell function using fasting insulin and glucose levels serve as surrogate measures of insulin sensitivity and secretion in nondiabetic youths. The validity of these conclusions in children with impaired glucose tolerance and type 2 diabetes mellitus remains to be determined.
OBJECTIVES: To compare insulin sensitivity and pancreatic beta-cell function measured by the euglycemic and the hyperglycemic clamp, with simple estimates of insulin sensitivity and pancreatic beta-cell function in youth. Study design We measured insulin sensitivity with a euglycemic clamp and first- and second-phase insulin secretion with a hyperglycemic clamp in 156 AA and white youths. Estimates of insulin sensitivity (fasting insulin level [I(F)], the ratio of fasting glucose [G(F)] to I(F) [G(F)/I(F)], homeostasis model assessment estimate of insulin sensitivity [HOMA IS], and quantitative insulin sensitivity check index [QUICKI]) and estimates of pancreatic beta-cell function (I(F), the ratio of I(F) to G(F) [I(F)/G(F)], and homeostasis model assessment estimate of pancreatic beta-cell function [HOMA %B]) were derived from fasting measurements. RESULTS: In the total group, IS(Eu) correlated strongly with I(F) (r=-0.92), G(F)/I(F) (r=0.92), HOMA IS (r=0.91), and QUICKI (r=0.91) (P<.01). First-phase and second-phase insulin secretion correlated with I(F), I(F)/G(F), and HOMA %B (first-phase insulin secretion: r=0.76, 0.79, 0.82; second-phase insulin secretion: r=0.83, 0.86, 0.86, respectively; P<.01). CONCLUSIONS: Simple estimates of insulin sensitivity and pancreatic beta-cell function using fasting insulin and glucose levels serve as surrogate measures of insulin sensitivity and secretion in nondiabetic youths. The validity of these conclusions in children with impaired glucose tolerance and type 2 diabetes mellitus remains to be determined.
Authors: Shana E McCormack; Meaghan A McCarthy; Loredana Farilla; Mirko I Hrovat; David M Systrom; Steven K Grinspoon; Amy Fleischman Journal: J Clin Endocrinol Metab Date: 2011-08-10 Impact factor: 5.958
Authors: C Giacomozzi; P Ghirri; R Lapolla; A Bartoli; G Scirè; L Serino; D Germani; A Boldrini; S Cianfarani Journal: J Endocrinol Invest Date: 2010-05-05 Impact factor: 4.256
Authors: M Santiago-Torres; Y Cui; A K Adams; D B Allen; A L Carrel; J Y Guo; A Delgado-Rendon; T L LaRowe; D A Schoeller Journal: Pediatr Obes Date: 2015-03-02 Impact factor: 4.000
Authors: Teresa Tamayo; David R Jacobs; Klaus Strassburger; Guido Giani; Teresa E Seeman; Karen Matthews; Jeffrey M Roseman; Wolfgang Rathmann Journal: Eur J Epidemiol Date: 2012-05-08 Impact factor: 8.082
Authors: Tina K Jensen; Amalie G Timmermann; Laura I Rossing; Mathias Ried-Larsen; Anders Grøntved; Lars B Andersen; Christine Dalgaard; Oluf H Hansen; Thomas Scheike; Flemming Nielsen; Philippe Grandjean Journal: J Clin Endocrinol Metab Date: 2014-12 Impact factor: 5.958