UNLABELLED: MRI offers perfect visualization of spondylotic stenosis of the cervical spine, but morphologic imaging does not correlate with clinical symptoms and postoperative recovery after decompression surgery. In this prospective study, we investigated the role of (18)F-FDG PET in patients with degenerative stenosis of the cervical spinal cord in relation to postsurgical outcome. METHODS: Twenty patients with monosegmental spondylotic stenosis of the middle cervical spine (C3/C4 or C4/C5) showing intramedullary hyperintensity on T2-weighted MRI and clinical symptoms of myelopathy (myelopathic patients) were investigated by (18)F-FDG PET. Maximum standardized uptake values (SUV(max)) were measured at all levels of the cervical spine (C1-C7). Decompression surgery and anterior cervical fusion were performed on all patients, and clinical status (Japanese Orthopedic Association [JOA] score) was assessed before and 6 mo after surgery. The (18)F-FDG data of 10 individuals without cervical spine pathology were used as a reference (controls). RESULTS: The myelopathic patients showed a significant decrease in (18)F-FDG uptake in the area of the lower cervical cord, compared with the control group (C7 SUV(max), 1.49 ± 0.18 vs. 1.71 ± 0.27, P = 0.01). Ten myelopathic patients exhibited focally increased (18)F-FDG uptake at the level of the stenosis (SUV(max), 2.27 ± 0.41 vs. 1.75 ± 0.22, P = 0.002). The remaining 10 patients showed inconspicuous (18)F-FDG uptake at the area of the stenosis. Postoperatively, the patients with focally increased (18)F-FDG accumulation at the level of stenosis showed good clinical recovery and a significant improvement in JOA scores (13.6 ± 2.3 vs. 9.5 ± 2.5, P = 0.001), whereas no significant improvement was observed in the remaining patients (JOA score, 12.0 ± 2.4 vs. 11.6 ± 2.5, not statistically significant). Multiple regression analysis identified the presence of focally increased (18)F-FDG uptake at the level of the stenosis as an independent predictor of postoperative outcome (P = 0.002). CONCLUSION: The results suggest that regional changes in (18)F-FDG uptake have prognostic significance in compression-induced cervical myelopathy that may be helpful in decisions on the timing of surgery.
UNLABELLED: MRI offers perfect visualization of spondylotic stenosis of the cervical spine, but morphologic imaging does not correlate with clinical symptoms and postoperative recovery after decompression surgery. In this prospective study, we investigated the role of (18)F-FDG PET in patients with degenerative stenosis of the cervical spinal cord in relation to postsurgical outcome. METHODS: Twenty patients with monosegmental spondylotic stenosis of the middle cervical spine (C3/C4 or C4/C5) showing intramedullary hyperintensity on T2-weighted MRI and clinical symptoms of myelopathy (myelopathicpatients) were investigated by (18)F-FDG PET. Maximum standardized uptake values (SUV(max)) were measured at all levels of the cervical spine (C1-C7). Decompression surgery and anterior cervical fusion were performed on all patients, and clinical status (Japanese Orthopedic Association [JOA] score) was assessed before and 6 mo after surgery. The (18)F-FDG data of 10 individuals without cervical spine pathology were used as a reference (controls). RESULTS: The myelopathicpatients showed a significant decrease in (18)F-FDG uptake in the area of the lower cervical cord, compared with the control group (C7 SUV(max), 1.49 ± 0.18 vs. 1.71 ± 0.27, P = 0.01). Ten myelopathicpatients exhibited focally increased (18)F-FDG uptake at the level of the stenosis (SUV(max), 2.27 ± 0.41 vs. 1.75 ± 0.22, P = 0.002). The remaining 10 patients showed inconspicuous (18)F-FDG uptake at the area of the stenosis. Postoperatively, the patients with focally increased (18)F-FDG accumulation at the level of stenosis showed good clinical recovery and a significant improvement in JOA scores (13.6 ± 2.3 vs. 9.5 ± 2.5, P = 0.001), whereas no significant improvement was observed in the remaining patients (JOA score, 12.0 ± 2.4 vs. 11.6 ± 2.5, not statistically significant). Multiple regression analysis identified the presence of focally increased (18)F-FDG uptake at the level of the stenosis as an independent predictor of postoperative outcome (P = 0.002). CONCLUSION: The results suggest that regional changes in (18)F-FDG uptake have prognostic significance in compression-induced cervical myelopathy that may be helpful in decisions on the timing of surgery.
Authors: Maximilian Reinhold; Christian Ederer; Benjamin Henninger; Alexandra Eberwein; Christian Kremser Journal: Eur Spine J Date: 2014-10-09 Impact factor: 3.134
Authors: Daniele Bertoglio; Nicolas Halloin; Stef De Lombaerde; Aleksandar Jankovski; Jeroen Verhaeghe; Charles Nicaise; Steven Staelens Journal: J Nucl Med Date: 2022-01-13 Impact factor: 11.082
Authors: P W Stroman; C Wheeler-Kingshott; M Bacon; J M Schwab; R Bosma; J Brooks; D Cadotte; T Carlstedt; O Ciccarelli; J Cohen-Adad; A Curt; N Evangelou; M G Fehlings; M Filippi; B J Kelley; S Kollias; A Mackay; C A Porro; S Smith; S M Strittmatter; P Summers; I Tracey Journal: Neuroimage Date: 2013-05-14 Impact factor: 6.556
Authors: Kimberly R Byrnes; Colin M Wilson; Fiona Brabazon; Ramona von Leden; Jennifer S Jurgens; Terrence R Oakes; Reed G Selwyn Journal: Front Neuroenergetics Date: 2014-01-09
Authors: Bryn Hilton; Jennifer Tempest-Mitchell; Benjamin M Davies; Jibin Francis; Richard J Mannion; Rikin Trivedi; Ivan Timofeev; John R Crawford; Douglas Hay; Rodney J Laing; Peter J Hutchinson; Mark R N Kotter Journal: PLoS One Date: 2019-12-26 Impact factor: 3.240
Authors: Allan R Martin; Lindsay Tetreault; Aria Nouri; Armin Curt; Patrick Freund; Vafa Rahimi-Movaghar; Jefferson R Wilson; Michael G Fehlings; Brian K Kwon; James S Harrop; Benjamin M Davies; Mark R N Kotter; James D Guest; Bizhan Aarabi; Shekar N Kurpad Journal: Global Spine J Date: 2021-11-19