OBJECTIVE: To assess the accuracy of targeted dual-energy single-source multi-detector CT (MDCT) for characterisation of urinary calculi. METHODS: For proof of principle, 71 ex-vivo calculi underwent single-source 256-slice MDCT. Low-dose CT was performed in 154 patients with suspected urinary calculi. In 104 patients with urinary calculi targeted dual-energy imaging within one breath-hold was added. 46 patients with sufficient material for infrared-spectroscopy were analysed. Potential anatomical misregistrations between 80- and 140-kV(p)-images and HU-values were measured. DEIs (dual-energy-indices) were compared with the standard of reference. Effective doses were calculated. RESULTS: In 26 of 46 patients no misregistration was present. Mean deviations were 2.7 mm in the z-axis (16 patients) and 4.3 mm in the axial plane (10 patients). The DEIs were 0.018 ± 0.016 for uric acid (UA), 0.035 ± 0.015 for mixed UA and 0.102 ± 0.015 for calcified stones in-vitro and 0.017 ± 0.002 for UA, 0.050 ± 0.019 for mixed UA and 0.122 ± 0.024 for calcified calculi in-vivo. Significant differences were noted among calcium, mixed UA and UA stones (p < 0.05). For the low-dose examination mean effective dose was 3.11 mSv. Targed dual-energy resulted in an extra dose of 1.84 mSv (additional 59.1%). CONCLUSION: Targeted dual-energy imaging within one breath-hold is feasible for characterisation of urinary calculi using single-source MDCT allowing minimal anatomical discordance.
OBJECTIVE: To assess the accuracy of targeted dual-energy single-source multi-detector CT (MDCT) for characterisation of urinary calculi. METHODS: For proof of principle, 71 ex-vivo calculi underwent single-source 256-slice MDCT. Low-dose CT was performed in 154 patients with suspected urinary calculi. In 104 patients with urinary calculi targeted dual-energy imaging within one breath-hold was added. 46 patients with sufficient material for infrared-spectroscopy were analysed. Potential anatomical misregistrations between 80- and 140-kV(p)-images and HU-values were measured. DEIs (dual-energy-indices) were compared with the standard of reference. Effective doses were calculated. RESULTS: In 26 of 46 patients no misregistration was present. Mean deviations were 2.7 mm in the z-axis (16 patients) and 4.3 mm in the axial plane (10 patients). The DEIs were 0.018 ± 0.016 for uric acid (UA), 0.035 ± 0.015 for mixed UA and 0.102 ± 0.015 for calcified stones in-vitro and 0.017 ± 0.002 for UA, 0.050 ± 0.019 for mixed UA and 0.122 ± 0.024 for calcified calculi in-vivo. Significant differences were noted among calcium, mixed UA and UA stones (p < 0.05). For the low-dose examination mean effective dose was 3.11 mSv. Targed dual-energy resulted in an extra dose of 1.84 mSv (additional 59.1%). CONCLUSION: Targeted dual-energy imaging within one breath-hold is feasible for characterisation of urinary calculi using single-source MDCT allowing minimal anatomical discordance.
Authors: Paul Stolzmann; Hans Scheffel; Katharina Rentsch; Thomas Schertler; Thomas Frauenfelder; Sebastian Leschka; Tullio Sulser; Borut Marincek; Hatem Alkadhi Journal: Urol Res Date: 2008-06-11
Authors: C Thomas; O Patschan; D Ketelsen; I Tsiflikas; A Reimann; H Brodoefel; M Buchgeister; U Nagele; A Stenzl; C Claussen; A Kopp; M Heuschmid; H-P Schlemmer Journal: Eur Radiol Date: 2009-02-10 Impact factor: 5.315
Authors: Anno Graser; Thorsten R C Johnson; Markus Bader; Michael Staehler; Nicolas Haseke; Konstantin Nikolaou; Maximilian F Reiser; Christian G Stief; Christoph R Becker Journal: Invest Radiol Date: 2008-02 Impact factor: 6.016
Authors: Shuai Leng; Maria Shiung; Songtao Ai; Mingliang Qu; Terri J Vrtiska; Katharine L Grant; Bernhard Krauss; Bernhard Schmidt; John C Lieske; Cynthia H McCollough Journal: AJR Am J Roentgenol Date: 2015-01 Impact factor: 3.959
Authors: Murat Akand; Mustafa Koplay; Necat Islamoglu; Murat Gul; Ozcan Kilic; Merter Bora Erdogdu Journal: Int Urol Nephrol Date: 2016-05-20 Impact factor: 2.370
Authors: Maria A Jepperson; David D Thiel; Joesph G Cernigliaro; Gregory A Broderick; Alexander S Parker; William E Haley Journal: Urology Date: 2012-08-22 Impact factor: 2.649
Authors: Shuai Leng; Alice Huang; Juan Montoya Cardona; Xinhui Duan; James C Williams; Cynthia H McCollough Journal: AJR Am J Roentgenol Date: 2016-05-25 Impact factor: 3.959