Literature DB >> 21841785

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation.

Marc Beyer1, Yasser Thabet, Roman-Ulrich Müller, Timothy Sadlon, Sabine Classen, Katharina Lahl, Samik Basu, Xuyu Zhou, Samantha L Bailey-Bucktrout, Wolfgang Krebs, Eva A Schönfeld, Jan Böttcher, Tatiana Golovina, Christian T Mayer, Andrea Hofmann, Daniel Sommer, Svenja Debey-Pascher, Elmar Endl, Andreas Limmer, Keli L Hippen, Bruce R Blazar, Robert Balderas, Thomas Quast, Andreas Waha, Günter Mayer, Michael Famulok, Percy A Knolle, Claudia Wickenhauser, Waldemar Kolanus, Bernhard Schermer, Jeffrey A Bluestone, Simon C Barry, Tim Sparwasser, James L Riley, Joachim L Schultze.   

Abstract

Regulatory T cells (T(reg) cells) are essential for self-tolerance and immune homeostasis. Lack of effector T cell (T(eff) cell) function and gain of suppressive activity by T(reg) cells are dependent on the transcriptional program induced by Foxp3. Here we report that repression of SATB1, a genome organizer that regulates chromatin structure and gene expression, was crucial for the phenotype and function of T(reg) cells. Foxp3, acting as a transcriptional repressor, directly suppressed the SATB1 locus and indirectly suppressed it through the induction of microRNAs that bound the SATB1 3' untranslated region. Release of SATB1 from the control of Foxp3 in T(reg) cells caused loss of suppressive function, establishment of transcriptional T(eff) cell programs and induction of T(eff) cell cytokines. Our data support the proposal that inhibition of SATB1-mediated modulation of global chromatin remodeling is pivotal for maintaining T(reg) cell functionality.

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Year:  2011        PMID： 21841785      PMCID： PMC3669688          DOI： 10.1038/ni.2084

Source DB:  PubMed          Journal:  Nat Immunol        ISSN： 1529-2908            Impact factor:   25.606


  55 in total

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Journal:  Immunity       Date:  2009-01-16       Impact factor: 31.745

Review 5.  Plasticity of CD4(+) FoxP3(+) T cells.

Authors:  Xuyu Zhou; Samantha Bailey-Bucktrout; Lukas T Jeker; Jeffrey A Bluestone
Journal:  Curr Opin Immunol       Date:  2009-06-06       Impact factor: 7.486

6.  The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation.

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Journal:  Immunity       Date:  2009-01-16       Impact factor: 31.745

8.  Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses.

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Authors:  Xuyu Zhou; Samantha L Bailey-Bucktrout; Lukas T Jeker; Cristina Penaranda; Marc Martínez-Llordella; Meredith Ashby; Maki Nakayama; Wendy Rosenthal; Jeffrey A Bluestone
Journal:  Nat Immunol       Date:  2009-07-26       Impact factor: 25.606
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  90 in total

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Review 2.  Genome organizing function of SATB1 in tumor progression.

Authors:  Terumi Kohwi-Shigematsu; Krzysztof Poterlowicz; Ellen Ordinario; Hye-Jung Han; Vladimir A Botchkarev; Yoshinori Kohwi
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Review 5.  Treg cells in autoimmunity: from identification to Treg-based therapies.

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Review 6.  Epigenetic regulation of T helper cells and intestinal pathogenicity.

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7.  Epigenetic orchestration of thymic Treg cell development.

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Journal:  Nat Immunol       Date:  2017-01-19       Impact factor: 25.606

8.  Proteomic Analysis of Regulatory T Cells Reveals the Importance of Themis1 in the Control of Their Suppressive Function.

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Review 9.  Induced regulatory T cells in inhibitory microenvironments created by cancer.

Authors:  Theresa L Whiteside
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10.  Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection.

Authors:  Marc Beyer; Zeinab Abdullah; Jens M Chemnitz; Daniela Maisel; Jil Sander; Clara Lehmann; Yasser Thabet; Prashant V Shinde; Lisa Schmidleithner; Maren Köhne; Jonel Trebicka; Robert Schierwagen; Andrea Hofmann; Alexey Popov; Karl S Lang; Annette Oxenius; Thorsten Buch; Christian Kurts; Mathias Heikenwalder; Gerd Fätkenheuer; Philipp A Lang; Pia Hartmann; Percy A Knolle; Joachim L Schultze
Journal:  Nat Immunol       Date:  2016-03-07       Impact factor: 25.606
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