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Literature DB >> 19536194

Foxp3+ regulatory T cells: differentiation, specification, subphenotypes.

Markus Feuerer¹, Jonathan A Hill, Diane Mathis, Christophe Benoist.

Abstract

Regulatory T cells (T(reg) cells) characterized by expression of the transcription factor Foxp3 play a key role in immune homeostasis. Rather than a monomorphic population strictly determined by Foxp3 as a 'master regulator', the emerging view is one of T(reg) cells as a population with many levels of complexity. Several regulatory factors partake in the control of their transcriptional 'signature', with Foxp3 being a key regulator but insufficient and unnecessary to specify all aspects of the lineage. Distinct subphenotypes of Foxp3+ T(reg) cells are found in different anatomical locations. Some subphenotypes specifically control different facets of effector T cell function and, perhaps surprisingly, share transcriptional control elements with the very cells they regulate. This review will focus on these novel aspects of T(reg) cell diversity.

Entities: Disease Gene

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Year: 2009 PMID： 19536194 DOI： 10.1038/ni.1760

Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 25.606

111 in total

1. Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance.

Authors: Xin Xiao Zheng; Alberto Sánchez-Fueyo; Masayuki Sho; Christoph Domenig; Mohamed H Sayegh; Terry B Strom
Journal: Immunity Date: 2003-10 Impact factor: 31.745

2. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.

Authors: Xuguang Tai; Michelle Cowan; Lionel Feigenbaum; Alfred Singer
Journal: Nat Immunol Date: 2005-01-09 Impact factor: 25.606

3. Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity.

Authors: Noriko Komatsu; Maria Encarnita Mariotti-Ferrandiz; Ying Wang; Bernard Malissen; Herman Waldmann; Shohei Hori
Journal: Proc Natl Acad Sci U S A Date: 2009-01-27 Impact factor: 11.205

4. Mature T cells depend on signaling through the IKK complex.

Authors: Marc Schmidt-Supprian; Gilles Courtois; Jane Tian; Anthony J Coyle; Alain Israël; Klaus Rajewsky; Manolis Pasparakis
Journal: Immunity Date: 2003-09 Impact factor: 31.745

5. The effect of immunosuppressive drug rapamycin on regulatory CD4+CD25+Foxp3+T cells in mice.

Authors: Yanyan Qu; Baojun Zhang; Liang Zhao; Guangwei Liu; Haixia Ma; Enyu Rao; Chun Zeng; Yong Zhao
Journal: Transpl Immunol Date: 2007-01-24 Impact factor: 1.708

6. Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells.

Authors: Ye Zheng; Steven Z Josefowicz; Arnold Kas; Tin-Tin Chu; Marc A Gavin; Alexander Y Rudensky
Journal: Nature Date: 2007-01-21 Impact factor: 49.962

7. Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation.

Authors: Maria A Curotto de Lafaille; Nino Kutchukhidze; Shiqian Shen; Yi Ding; Herman Yee; Juan J Lafaille
Journal: Immunity Date: 2008-07-18 Impact factor: 31.745

Review 8. Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

Authors: Jochen Huehn; Julia K Polansky; Alf Hamann
Journal: Nat Rev Immunol Date: 2009-02 Impact factor: 53.106

9. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function.

Authors: Liang Zhou; Jared E Lopes; Mark M W Chong; Ivaylo I Ivanov; Roy Min; Gabriel D Victora; Yuelei Shen; Jianguang Du; Yuri P Rubtsov; Alexander Y Rudensky; Steven F Ziegler; Dan R Littman
Journal: Nature Date: 2008-03-26 Impact factor: 49.962

10. Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells.

Authors: Jochen Huehn; Kerstin Siegmund; Joachim C U Lehmann; Christiane Siewert; Uta Haubold; Markus Feuerer; Gudrun F Debes; Joerg Lauber; Oliver Frey; Grzegorz K Przybylski; Uwe Niesner; Maurus de la Rosa; Christian A Schmidt; Rolf Bräuer; Jan Buer; Alexander Scheffold; Alf Hamann
Journal: J Exp Med Date: 2004-02-02 Impact factor: 14.307

215 in total

Review 1. T cells as therapeutic targets in SLE.

Authors: José C Crispín; Vasileios C Kyttaris; Cox Terhorst; George C Tsokos
Journal: Nat Rev Rheumatol Date: 2010-05-11 Impact factor: 20.543

Review 2. Genetics, pathogenesis and clinical interventions in type 1 diabetes.

Authors: Jeffrey A Bluestone; Kevan Herold; George Eisenbarth
Journal: Nature Date: 2010-04-29 Impact factor: 49.962

3. Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.

Authors: Weiming Ouyang; Omar Beckett; Qian Ma; Ji-hye Paik; Ronald A DePinho; Ming O Li
Journal: Nat Immunol Date: 2010-05-13 Impact factor: 25.606

4. Genomic definition of multiple ex vivo regulatory T cell subphenotypes.

Authors: Markus Feuerer; Jonathan A Hill; Karsten Kretschmer; Harald von Boehmer; Diane Mathis; Christophe Benoist
Journal: Proc Natl Acad Sci U S A Date: 2010-03-15 Impact factor: 11.205

5. 2-Gy whole-body irradiation significantly alters the balance of CD4+ CD25- T effector cells and CD4+ CD25+ Foxp3+ T regulatory cells in mice.

Authors: Yanyan Qu; Baojun Zhang; Shuchun Liu; Aijun Zhang; Tingting Wu; Yong Zhao
Journal: Cell Mol Immunol Date: 2010-09-27 Impact factor: 11.530

10. Toll-like receptor 4 signaling leads to severe fungal infection associated with enhanced proinflammatory immunity and impaired expansion of regulatory T cells.

Authors: Flávio V Loures; Adriana Pina; Maíra Felonato; Eliseu F Araújo; Katia R M Leite; Vera L G Calich
Journal: Infect Immun Date: 2009-12-14 Impact factor: 3.441