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Literature DB >> 28102221

Epigenetic orchestration of thymic T_reg cell development.

Marc Beyer¹, Jochen Huehn².

Abstract

Mesh：

Substances：

Year: 2017 PMID： 28102221 DOI： 10.1038/ni.3660

Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 25.606

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11 in total

1. The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development.

Authors: J D Alvarez; D H Yasui; H Niida; T Joh; D Y Loh; T Kohwi-Shigematsu
Journal: Genes Dev Date: 2000-03-01 Impact factor: 11.361

Review 2. Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal.

Authors: Myriam Hemberger; Wendy Dean; Wolf Reik
Journal: Nat Rev Mol Cell Biol Date: 2009-07-15 Impact factor: 94.444

3. T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development.

Authors: Naganari Ohkura; Masahide Hamaguchi; Hiromasa Morikawa; Kyoko Sugimura; Atsushi Tanaka; Yoshinaga Ito; Motonao Osaki; Yoshiaki Tanaka; Riu Yamashita; Naoko Nakano; Jochen Huehn; Hans Joerg Fehling; Tim Sparwasser; Kenta Nakai; Shimon Sakaguchi
Journal: Immunity Date: 2012-11-01 Impact factor: 31.745

4. Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus.

Authors: Aras Toker; Dirk Engelbert; Garima Garg; Julia K Polansky; Stefan Floess; Takahisa Miyao; Udo Baron; Sandra Düber; Robert Geffers; Pascal Giehr; Sonja Schallenberg; Karsten Kretschmer; Sven Olek; Jörn Walter; Siegfried Weiss; Shohei Hori; Alf Hamann; Jochen Huehn
Journal: J Immunol Date: 2013-02-18 Impact factor: 5.422

5. Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation.

Authors: Marc Beyer; Yasser Thabet; Roman-Ulrich Müller; Timothy Sadlon; Sabine Classen; Katharina Lahl; Samik Basu; Xuyu Zhou; Samantha L Bailey-Bucktrout; Wolfgang Krebs; Eva A Schönfeld; Jan Böttcher; Tatiana Golovina; Christian T Mayer; Andrea Hofmann; Daniel Sommer; Svenja Debey-Pascher; Elmar Endl; Andreas Limmer; Keli L Hippen; Bruce R Blazar; Robert Balderas; Thomas Quast; Andreas Waha; Günter Mayer; Michael Famulok; Percy A Knolle; Claudia Wickenhauser; Waldemar Kolanus; Bernhard Schermer; Jeffrey A Bluestone; Simon C Barry; Tim Sparwasser; James L Riley; Joachim L Schultze
Journal: Nat Immunol Date: 2011-08-14 Impact factor: 25.606

6. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities.

Authors: Sven Heinz; Christopher Benner; Nathanael Spann; Eric Bertolino; Yin C Lin; Peter Laslo; Jason X Cheng; Cornelis Murre; Harinder Singh; Christopher K Glass
Journal: Mol Cell Date: 2010-05-28 Impact factor: 17.970

Epigenetic orchestration of thymic T_reg cell development.

1. The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development.

Review 2. Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal.

3. T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development.

4. Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus.

5. Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation.

6. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities.

7. Master transcription factors and mediator establish super-enhancers at key cell identity genes.

8. Tissue-specific nuclear architecture and gene expression regulated by SATB1.

9. A two-step process for thymic regulatory T cell development.

10. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate.

Review 1. Role of CNSs Conserved Distal Cis-Regulatory Elements in CD4 + T Cell Development and Differentiation.