| Literature DB >> 21833427 |
Sheng Lin1, Ting Shi, Ke-Yv Chen, Zhong-Xiao Zhang, Lei Shan, Yun-Heng Shen, Wei-Dong Zhang.
Abstract
Cyclopenicillone (1), possessing a unique 2,5-dimethylcyclopent-2-enone carbon skeleton, has been isolated from the cultures broth of the fungus Penicillium decumbens. The structure and absolute configuration of 1 were elucidated using a combination of NMR spectroscopy, CD data and computational approaches. Cyclopenicillone (1) demonstrated a dose-dependent (10-100 μM) inhibition against LPS-induced NO production in RAW264.7 macrophages. This journal is © The Royal Society of Chemistry 2011Entities:
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Year: 2011 PMID: 21833427 DOI: 10.1039/c1cc12079d
Source DB: PubMed Journal: Chem Commun (Camb) ISSN: 1359-7345 Impact factor: 6.222