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Literature DB >> 21802002

Finding the missing code of RNA recognition by PUF proteins.

Abstract

Pumilio and FBF homology (PUF) proteins represent highly promising candidates for engineering sequence-specific RNA recognition, but were only known to recognize G, A, and U, significantly limiting applications. Two groups (Filipovska et al., 2011; Dong et al., 2011) have now reported the discovery of the cytosine-recognition code for PUF proteins.

Entities: Chemical Gene Species

Year: 2011 PMID： 21802002 PMCID： PMC3161827 DOI： 10.1016/j.chembiol.2011.07.001

Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521

7 in total

1. Modular recognition of RNA by a human pumilio-homology domain.

Authors: Xiaoqiang Wang; Juanita McLachlan; Phillip D Zamore; Traci M Tanaka Hall
Journal: Cell Date: 2002-08-23 Impact factor: 41.582

2. Engineering RNA sequence specificity of Pumilio repeats.

Authors: Cheom-Gil Cheong; Traci M Tanaka Hall
Journal: Proc Natl Acad Sci U S A Date: 2006-09-05 Impact factor: 11.205

Review 3. RNA-binding proteins: modular design for efficient function.

Authors: Bradley M Lunde; Claire Moore; Gabriele Varani
Journal: Nat Rev Mol Cell Biol Date: 2007-06 Impact factor: 94.444

4. The prospects for designer single-stranded RNA-binding proteins.

Authors: Joel P Mackay; Josep Font; David J Segal
Journal: Nat Struct Mol Biol Date: 2011-02-27 Impact factor: 15.369

5. In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence.

Authors: Y Choo; I Sánchez-García; A Klug
Journal: Nature Date: 1994-12-15 Impact factor: 49.962

6. Imaging dynamics of endogenous mitochondrial RNA in single living cells.

Authors: Takeaki Ozawa; Yutaka Natori; Moritoshi Sato; Yoshio Umezawa
Journal: Nat Methods Date: 2007-04-01 Impact factor: 28.547

7. Engineering splicing factors with designed specificities.

Authors: Yang Wang; Cheom-Gil Cheong; Traci M Tanaka Hall; Zefeng Wang
Journal: Nat Methods Date: 2009-10-04 Impact factor: 28.547

7 in total

8 in total

Finding the missing code of RNA recognition by PUF proteins.

1. Modular recognition of RNA by a human pumilio-homology domain.

2. Engineering RNA sequence specificity of Pumilio repeats.

Review 3. RNA-binding proteins: modular design for efficient function.

4. The prospects for designer single-stranded RNA-binding proteins.

5. In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence.

6. Imaging dynamics of endogenous mitochondrial RNA in single living cells.

7. Engineering splicing factors with designed specificities.

1. Pentatricopeptide repeats: modular blocks for building RNA-binding proteins.

2. Synthetic RNA recognition motifs that selectively recognize HIV-1 trans-activation response element hairpin RNA.

3. Programmable RNA-binding protein composed of repeats of a single modular unit.

Review 4. Nucleic acid recognition by tandem helical repeats.

Review 5. Engineering RNA-binding proteins for biology.

Review 6. High-throughput characterization of protein-RNA interactions.

7. The role of RNA conformation in RNA-protein recognition.

Review 8. RNA modularity for synthetic biology.