Literature DB >> 21801009

The role of Atg proteins in autophagosome formation.

Noboru Mizushima1, Tamotsu Yoshimori, Yoshinori Ohsumi.   

Abstract

Macroautophagy is mediated by a unique organelle, the autophagosome, which encloses a portion of cytoplasm for delivery to the lysosome. Autophagosome formation is dynamically regulated by starvation and other stresses and involves complicated membrane reorganization. Since the discovery of yeast Atg-related proteins, autophagosome formation has been dissected at the molecular level. In this review we describe the molecular mechanism of autophagosome formation with particular focus on the function of Atg proteins and the long-standing discussion regarding the origin of the autophagosome membrane.

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Year:  2011        PMID： 21801009     DOI： 10.1146/annurev-cellbio-092910-154005

Source DB:  PubMed          Journal:  Annu Rev Cell Dev Biol        ISSN： 1081-0706            Impact factor:   13.827


  1196 in total

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