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Literature DB >> 32281411

Stem cell-based treatment of kidney diseases.

Abstract

IMPACT STATEMENT: Stem cells hold great promise in regenerative medicine. Pluripotent stem cells have been differentiated into kidney organoids to understand human kidney development and to dissect renal disease mechanisms. Meanwhile, recent studies have explored the treatment of kidney diseases using a variety of cells, including mesenchymal stem cells and renal derivatives. This mini-review discusses the diverse mechanisms underlying current renal disease treatment via stem cell therapy. We postulate that clinical applications of stem cell therapy for kidney diseases can be readily achieved in the near future.

Entities: Disease Species

Keywords: Cytokine therapy; acute kidney injury; chronic kidney disease; kidney organoids; mechanism

Mesh：

Year: 2020 PMID： 32281411 PMCID： PMC7268929 DOI： 10.1177/1535370220915901

Source DB: PubMed Journal: Exp Biol Med (Maywood) ISSN： 1535-3699

108 in total

1. Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis.

Authors: Minoru Takasato; Pei X Er; Han S Chiu; Barbara Maier; Gregory J Baillie; Charles Ferguson; Robert G Parton; Ernst J Wolvetang; Matthias S Roost; Susana M Chuva de Sousa Lopes; Melissa H Little
Journal: Nature Date: 2015-10-07 Impact factor: 49.962

2. Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis.

Authors: Peter E Czabotar; Dana Westphal; Grant Dewson; Stephen Ma; Colin Hockings; W Douglas Fairlie; Erinna F Lee; Shenggen Yao; Adeline Y Robin; Brian J Smith; David C S Huang; Ruth M Kluck; Jerry M Adams; Peter M Colman
Journal: Cell Date: 2013-01-31 Impact factor: 41.582

3. Autologous Hematopoietic Stem Cell Transplantation for Refractory Lupus Nephritis.

Authors: Xianghua Huang; Wencui Chen; Guisheng Ren; Liang Zhao; Jinzhou Guo; Dehua Gong; Caihong Zeng; Weixin Hu; Zhihong Liu
Journal: Clin J Am Soc Nephrol Date: 2019-04-12 Impact factor: 8.237

4. Exosomes from human-bone-marrow-derived mesenchymal stem cells protect against renal ischemia/reperfusion injury via transferring miR-199a-3p.

Authors: Gongmin Zhu; Lijiao Pei; Fan Lin; Hubin Yin; Xinyuan Li; Weiyang He; Nian Liu; Xin Gou
Journal: J Cell Physiol Date: 2019-06-10 Impact factor: 6.384

5. Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network.

Authors: Jian Hui Low; Pin Li; Elaine Guo Yan Chew; Bingrui Zhou; Keiichiro Suzuki; Tian Zhang; Michelle Mulan Lian; Meng Liu; Emi Aizawa; Concepcion Rodriguez Esteban; Kylie Su Mei Yong; Qingfeng Chen; Josep M Campistol; Mingliang Fang; Chiea Chuen Khor; Jia Nee Foo; Juan Carlos Izpisua Belmonte; Yun Xia
Journal: Cell Stem Cell Date: 2019-07-11 Impact factor: 24.633

6. Mesenchymal stem cell therapy ameliorates diabetic nephropathy via the paracrine effect of renal trophic factors including exosomes.

Authors: Kanna Nagaishi; Yuka Mizue; Takako Chikenji; Miho Otani; Masako Nakano; Naoto Konari; Mineko Fujimiya
Journal: Sci Rep Date: 2016-10-10 Impact factor: 4.379

7. Human Mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGE₂-dependent mechanism.

Authors: Anoop Babu Vasandan; Sowmya Jahnavi; Chandanala Shashank; Priya Prasad; Anujith Kumar; S Jyothi Prasanna
Journal: Sci Rep Date: 2016-12-02 Impact factor: 4.379

8. Investigated the safety of intra-renal arterial transfusion of autologous CD34+ cells and time courses of creatinine levels, endothelial dysfunction biomarkers and micro-RNAs in chronic kidney disease patients-phase I clinical trial.

Authors: Mel S Lee; Fan-Yen Lee; Yung-Lung Chen; Pei-Hsun Sung; Hsin-Ju Chiang; Kuan-Hung Chen; Tien-Hung Huang; Yi-Ling Chen; John Y Chiang; Tsung-Cheng Yin; Hsueh-Wen Chang; Hon-Kan Yip
Journal: Oncotarget Date: 2017-03-14

Stem cell-based treatment of kidney diseases.

1. Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis.

2. Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis.

3. Autologous Hematopoietic Stem Cell Transplantation for Refractory Lupus Nephritis.

4. Exosomes from human-bone-marrow-derived mesenchymal stem cells protect against renal ischemia/reperfusion injury via transferring miR-199a-3p.

5. Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network.

6. Mesenchymal stem cell therapy ameliorates diabetic nephropathy via the paracrine effect of renal trophic factors including exosomes.

7. Human Mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGE₂-dependent mechanism.

8. Investigated the safety of intra-renal arterial transfusion of autologous CD34+ cells and time courses of creatinine levels, endothelial dysfunction biomarkers and micro-RNAs in chronic kidney disease patients-phase I clinical trial.

9. Kynurenic acid, an IDO metabolite, controls TSG-6-mediated immunosuppression of human mesenchymal stem cells.

10. Kidney-derived c-kit⁺ progenitor/stem cells contribute to podocyte recovery in a model of acute proteinuria.

Review 1. Immune responses in diabetic nephropathy: Pathogenic mechanisms and therapeutic target.

Review 2. JMJD3: a critical epigenetic regulator in stem cell fate.