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Literature DB >> 21800073

Self-renewal related signaling in myeloid leukemia stem cells.

Florian H Heidel^1,2,3, Brenton G Mar^4,5, Scott A Armstrong^4,5,6.

Abstract

A key characteristic of hematopoietic stem cells (HSC) is the ability to self-renew. Several genes and signaling pathways control the fine balance between self-renewal and differentiation in HSC and potentially also in leukemic stem cells. Besides pathways such as Wnt signaling, Hedgehog signaling and Notch signaling, transcription factors (FoxOs) and cell fate determinants may also play a role in stem cells. While some of these pathways seem to be dispensable for maintenance of adult HSC, there may be a distinct requirement in leukemia stem cells for leukemic self-renewal. Here we will focus on self-renewal related signaling in myeloid leukemia stem cells and its therapeutic relevance.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Year: 2011 PMID： 21800073 PMCID： PMC3339405 DOI： 10.1007/s12185-011-0901-0

Source DB: PubMed Journal: Int J Hematol ISSN： 0925-5710 Impact factor: 2.490

72 in total

1. Resveratrol exerts antiproliferative activity and induces apoptosis in Waldenström's macroglobulinemia.

Authors: Aldo M Roccaro; Xavier Leleu; Antonio Sacco; Anne-Sophie Moreau; Evdoxia Hatjiharissi; Xiaoying Jia; Lian Xu; Bryan Ciccarelli; Christopher J Patterson; Hai T Ngo; Domenico Russo; Angelo Vacca; Franco Dammacco; Kenneth C Anderson; Irene M Ghobrial; Steven P Treon
Journal: Clin Cancer Res Date: 2008-03-15 Impact factor: 12.531

2. Imaging hematopoietic precursor division in real time.

Authors: Mingfu Wu; Hyog Young Kwon; Frederique Rattis; Jordan Blum; Chen Zhao; Rina Ashkenazi; Trachette L Jackson; Nicholas Gaiano; Tim Oliver; Tannishtha Reya
Journal: Cell Stem Cell Date: 2007-11 Impact factor: 24.633

3. Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

Authors: Kana Miyamoto; Kiyomi Y Araki; Kazuhito Naka; Fumio Arai; Keiyo Takubo; Satoshi Yamazaki; Sahoko Matsuoka; Takeshi Miyamoto; Keisuke Ito; Masako Ohmura; Chen Chen; Kentaro Hosokawa; Hiromitsu Nakauchi; Keiko Nakayama; Keiichi I Nakayama; Mine Harada; Noboru Motoyama; Toshio Suda; Atsushi Hirao
Journal: Cell Stem Cell Date: 2007-06-07 Impact factor: 24.633

Review 4. FoxO transcription factors and stem cell homeostasis: insights from the hematopoietic system.

Authors: Zuzana Tothova; D Gary Gilliland
Journal: Cell Stem Cell Date: 2007-08-16 Impact factor: 24.633

5. Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation.

Authors: Annelie E Abrahamsson; Ifat Geron; Jason Gotlib; Kim-Hien T Dao; Charlene F Barroga; Isabel G Newton; Francis J Giles; Jeffrey Durocher; Remi S Creusot; Mobin Karimi; Carol Jones; James L Zehnder; Armand Keating; Robert S Negrin; Irving L Weissman; Catriona H M Jamieson
Journal: Proc Natl Acad Sci U S A Date: 2009-02-23 Impact factor: 11.205

6. beta-Catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCR-ABL-induced chronic myeloid leukemia.

Authors: Y Hu; Y Chen; L Douglas; S Li
Journal: Leukemia Date: 2008-09-25 Impact factor: 11.528

7. Down-regulation of Notch-1 expression decreases PU.1-mediated myeloid differentiation signaling in acute myeloid leukemia.

Authors: Po-Min Chen; Chueh-Chuan Yen; Wei-Shu Wang; Yu-Jen Lin; Chiau-Jun Chu; Tzeon-Jye Chiou; Jin-Hwang Liu; Muh-Hwa Yang
Journal: Int J Oncol Date: 2008-06 Impact factor: 5.650

8. Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo.

Authors: Heather E Fleming; Viktor Janzen; Cristina Lo Celso; Jun Guo; Kathleen M Leahy; Henry M Kronenberg; David T Scadden
Journal: Cell Stem Cell Date: 2008-03-06 Impact factor: 24.633

9. Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration.

Authors: Wolfram Goessling; Trista E North; Sabine Loewer; Allegra M Lord; Sang Lee; Cristi L Stoick-Cooper; Gilbert Weidinger; Mark Puder; George Q Daley; Randall T Moon; Leonard I Zon
Journal: Cell Date: 2009-03-20 Impact factor: 41.582

10. Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation.

Authors: Christine Dierks; Ronak Beigi; Gui-Rong Guo; Katja Zirlik; Mario R Stegert; Paul Manley; Christopher Trussell; Annette Schmitt-Graeff; Klemens Landwerlin; Hendrik Veelken; Markus Warmuth
Journal: Cancer Cell Date: 2008-09-09 Impact factor: 31.743

20 in total

Review 1. The Interaction Between Niche and Hematopoietic Stem Cells.

Authors: Chaoyu Wang; Chen Tian; Yizhuo Zhang
Journal: Indian J Hematol Blood Transfus Date: 2016-01-12 Impact factor: 0.900

Review 2. Epigenetic regulation of hematopoiesis.

Authors: Goro Sashida; Atsushi Iwama
Journal: Int J Hematol Date: 2012-09-29 Impact factor: 2.490

3. Sex hormone drives blood stem cell reproduction.

Authors: Vincenzo Calvanese; Lydia K Lee; Hanna K A Mikkola
Journal: EMBO J Date: 2014-02-20 Impact factor: 11.598

4. Aberrant RNA splicing and mutations in spliceosome complex in acute myeloid leukemia.

Authors: Jianbiao Zhou; Wee-Joo Chng
Journal: Stem Cell Investig Date: 2017-02-09

5. Connective tissue growth factor regulates adipocyte differentiation of mesenchymal stromal cells and facilitates leukemia bone marrow engraftment.

Authors: V Lokesh Battula; Ye Chen; Maria da Graca Cabreira; Vivian Ruvolo; Zhiqiang Wang; Wencai Ma; Sergej Konoplev; Elizabeth Shpall; Karen Lyons; Dirk Strunk; Carlos Bueso-Ramos; Richard Eric Davis; Marina Konopleva; Michael Andreeff
Journal: Blood Date: 2013-06-05 Impact factor: 22.113

6. IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics.

Authors: Masato Sasaki; Christiane B Knobbe; Joshua C Munger; Evan F Lind; Dirk Brenner; Anne Brüstle; Isaac S Harris; Roxanne Holmes; Andrew Wakeham; Jillian Haight; Annick You-Ten; Wanda Y Li; Stefanie Schalm; Shinsan M Su; Carl Virtanen; Guido Reifenberger; Pamela S Ohashi; Dwayne L Barber; Maria E Figueroa; Ari Melnick; Juan-Carlos Zúñiga-Pflücker; Tak W Mak
Journal: Nature Date: 2012-08-30 Impact factor: 49.962

Review 7. Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development.

Authors: T C Luis; M Ichii; M H Brugman; P Kincade; F J T Staal
Journal: Leukemia Date: 2011-12-15 Impact factor: 11.528