Literature DB >> 23382113

Next-generation medicine: combining BCR-ABL and Hedgehog-targeted therapies.

Kim-Hien T Dao1, Jeffrey W Tyner.   

Abstract

Disease relapse remains a major cause of death in patients with BCR-ABL-positive leukemia despite advances in treatment with kinase inhibitors. Significant efforts are underway to target pathways that maintain leukemia stem cells. Targeting these pathways holds promise for definitive leukemia eradication or improvement of the effectiveness of currently available therapies.

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Year:  2013        PMID： 23382113      PMCID： PMC3602391          DOI： 10.1158/1078-0432.CCR-12-3934

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  12 in total

1.  Tracking molecular relapse of chronic myeloid leukemia by measuring Hedgehog signaling status.

Authors:  Michele Cea; Antonia Cagnetta; Gabriella Cirmena; Anna Garuti; Ilaria Rocco; Claudia Palermo; Ivana Pierri; Daniele Reverberi; Alessio Nencioni; Alberto Ballestrero; Marco Gobbi; Angelo Michele Carella; Franco Patrone
Journal:  Leuk Lymphoma       Date:  2012-09-05

Review 2.  Novel therapeutic approach to eradicate tyrosine kinase inhibitor resistant chronic myeloid leukemia stem cells.

Authors:  Kazuhito Naka; Takayuki Hoshii; Atsushi Hirao
Journal:  Cancer Sci       Date:  2010-04-05       Impact factor: 6.716

Review 3.  Intricacies of hedgehog signaling pathways: a perspective in tumorigenesis.

Authors:  Swayamsiddha Kar; Moonmoon Deb; Dipta Sengupta; Arunima Shilpi; Sujit Kumar Bhutia; Samir Kumar Patra
Journal:  Exp Cell Res       Date:  2012-05-31       Impact factor: 3.905

Review 4.  Mechanisms of resistance to tyrosine kinase inhibitors in chronic myeloid leukemia and recent therapeutic strategies to overcome resistance.

Authors:  Dale Bixby; Moshe Talpaz
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2009

5.  Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis.

Authors:  Inga Hofmann; Elizabeth H Stover; Dana E Cullen; Junhao Mao; Kelly J Morgan; Benjamin H Lee; Michael G Kharas; Peter G Miller; Melanie G Cornejo; Rachel Okabe; Scott A Armstrong; Nico Ghilardi; Stephen Gould; Frederic J de Sauvage; Andrew P McMahon; D Gary Gilliland
Journal:  Cell Stem Cell       Date:  2009-06-05       Impact factor: 24.633

6.  Hedgehog signaling is dispensable for adult hematopoietic stem cell function.

Authors:  Jie Gao; Stephanie Graves; Ute Koch; Suqing Liu; Vladimir Jankovic; Silvia Buonamici; Abdeljabar El Andaloussi; Stephen D Nimer; Barbara L Kee; Russell Taichman; Freddy Radtke; Iannis Aifantis
Journal:  Cell Stem Cell       Date:  2009-06-05       Impact factor: 24.633

7.  Combination of ponatinib with Hedgehog antagonist vismodegib for therapy-resistant BCR-ABL1-positive leukemia.

Authors:  Seiichiro Katagiri; Tetsuzo Tauchi; Seiichi Okabe; Yosuke Minami; Shinya Kimura; Taira Maekawa; Tomoki Naoe; Kazuma Ohyashiki
Journal:  Clin Cancer Res       Date:  2013-01-14       Impact factor: 12.531

8.  Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia.

Authors:  Chen Zhao; Alan Chen; Catriona H Jamieson; Mark Fereshteh; Annelie Abrahamsson; Jordan Blum; Hyog Young Kwon; Jynho Kim; John P Chute; David Rizzieri; Michael Munchhof; Todd VanArsdale; Philip A Beachy; Tannishtha Reya
Journal:  Nature       Date:  2009-04-09       Impact factor: 49.962

9.  Activation of the Hedgehog pathway in chronic myelogeneous leukemia patients.

Authors:  Bing Long; Huanling Zhu; Cuixia Zhu; Ting Liu; Wentong Meng
Journal:  J Exp Clin Cancer Res       Date:  2011-01-16

10.  Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation.

Authors:  Christine Dierks; Ronak Beigi; Gui-Rong Guo; Katja Zirlik; Mario R Stegert; Paul Manley; Christopher Trussell; Annette Schmitt-Graeff; Klemens Landwerlin; Hendrik Veelken; Markus Warmuth
Journal:  Cancer Cell       Date:  2008-09-09       Impact factor: 31.743
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  2 in total

1.  Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia.

Authors:  D Kern; G Regl; S W Hofbauer; P Altenhofer; G Achatz; A Dlugosz; H Schnidar; R Greil; T N Hartmann; F Aberger
Journal:  Oncogene       Date:  2015-02-02       Impact factor: 9.867

Review 2.  Resistant mutations in CML and Ph(+)ALL - role of ponatinib.

Authors:  Geoffrey D Miller; Benjamin J Bruno; Carol S Lim
Journal:  Biologics       Date:  2014-10-20
  2 in total

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