| Literature DB >> 21798943 |
M Shahid Mukhtar1, Anne-Ruxandra Carvunis, Matija Dreze, Petra Epple, Jens Steinbrenner, Jonathan Moore, Murat Tasan, Mary Galli, Tong Hao, Marc T Nishimura, Samuel J Pevzner, Susan E Donovan, Lila Ghamsari, Balaji Santhanam, Viviana Romero, Matthew M Poulin, Fana Gebreab, Bryan J Gutierrez, Stanley Tam, Dario Monachello, Mike Boxem, Christopher J Harbort, Nathan McDonald, Lantian Gai, Huaming Chen, Yijian He, Jean Vandenhaute, Frederick P Roth, David E Hill, Joseph R Ecker, Marc Vidal, Jim Beynon, Pascal Braun, Jeffery L Dangl.
Abstract
Plants generate effective responses to infection by recognizing both conserved and variable pathogen-encoded molecules. Pathogens deploy virulence effector proteins into host cells, where they interact physically with host proteins to modulate defense. We generated an interaction network of plant-pathogen effectors from two pathogens spanning the eukaryote-eubacteria divergence, three classes of Arabidopsis immune system proteins, and ~8000 other Arabidopsis proteins. We noted convergence of effectors onto highly interconnected host proteins and indirect, rather than direct, connections between effectors and plant immune receptors. We demonstrated plant immune system functions for 15 of 17 tested host proteins that interact with effectors from both pathogens. Thus, pathogens from different kingdoms deploy independently evolved virulence proteins that interact with a limited set of highly connected cellular hubs to facilitate their diverse life-cycle strategies.Entities:
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Year: 2011 PMID： 21798943 PMCID： PMC3170753 DOI： 10.1126/science.1203659
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728