OBJECTIVE: A time normalisation method of tumour SUVs in (18) F-FDG PET imaging is proposed that has been verified in lung cancer patients. METHODS: A two-compartment model analysis showed that, when SUV is not corrected for (18) F physical decay (SUV(uncorr)), its value is within 5% of its peak value (t = 79 min) between 55 and 110 min after injection, in each individual patient. In 10 patients, each with 1 or more malignant lesions (n = 15), two PET acquisitions were performed within this time delay, and the maximal SUV of each lesion, both corrected and uncorrected, was assessed. RESULTS: No significant difference was found between the two uncorrected SUVs, whereas there was a significant difference between the two corrected ones: mean differences were 0.04 ± 0.22 and 3.24 ± 0.75 g.ml(-1), respectively (95% confidence intervals). Therefore, a simple normalisation of decay-corrected SUV for time differences after injection is proposed: SUV(N) = 1.66 SUV(uncorr), where the factor 1.66 arises from decay correction at t = 79 min. CONCLUSIONS: When (18) F-FDG PET imaging is performed within the range 55-110 min after injection, a simple SUV normalisation for time differences after injection has been verified in patients with lung cancer, with a ±2.5% relative measurement uncertainty.
OBJECTIVE: A time normalisation method of tumour SUVs in (18) F-FDG PET imaging is proposed that has been verified in lung cancerpatients. METHODS: A two-compartment model analysis showed that, when SUV is not corrected for (18) F physical decay (SUV(uncorr)), its value is within 5% of its peak value (t = 79 min) between 55 and 110 min after injection, in each individual patient. In 10 patients, each with 1 or more malignant lesions (n = 15), two PET acquisitions were performed within this time delay, and the maximal SUV of each lesion, both corrected and uncorrected, was assessed. RESULTS: No significant difference was found between the two uncorrected SUVs, whereas there was a significant difference between the two corrected ones: mean differences were 0.04 ± 0.22 and 3.24 ± 0.75 g.ml(-1), respectively (95% confidence intervals). Therefore, a simple normalisation of decay-corrected SUV for time differences after injection is proposed: SUV(N) = 1.66 SUV(uncorr), where the factor 1.66 arises from decay correction at t = 79 min. CONCLUSIONS: When (18) F-FDG PET imaging is performed within the range 55-110 min after injection, a simple SUV normalisation for time differences after injection has been verified in patients with lung cancer, with a ±2.5% relative measurement uncertainty.
Authors: Dominique Delbeke; R Edward Coleman; Milton J Guiberteau; Manuel L Brown; Henry D Royal; Barry A Siegel; David W Townsend; Lincoln L Berland; J Anthony Parker; Karl Hubner; Michael G Stabin; George Zubal; Marc Kachelriess; Valerie Cronin; Scott Holbrook Journal: J Nucl Med Date: 2006-05 Impact factor: 10.057
Authors: P Som; H L Atkins; D Bandoypadhyay; J S Fowler; R R MacGregor; K Matsui; Z H Oster; D F Sacker; C Y Shiue; H Turner; C N Wan; A P Wolf; S V Zabinski Journal: J Nucl Med Date: 1980-07 Impact factor: 10.057
Authors: Pavlos P Kafouris; Iosif P Koutagiar; Alexandros T Georgakopoulos; Nikoletta K Pianou; Marinos G Metaxas; George M Spyrou; Constantinos D Anagnostopoulos Journal: Int J Cardiovasc Imaging Date: 2019-01-31 Impact factor: 2.357
Authors: Laure Fournier; Lioe-Fee de Geus-Oei; Daniele Regge; Daniela-Elena Oprea-Lager; Melvin D'Anastasi; Luc Bidaut; Tobias Bäuerle; Egesta Lopci; Giovanni Cappello; Frederic Lecouvet; Marius Mayerhoefer; Wolfgang G Kunz; Joost J C Verhoeff; Damiano Caruso; Marion Smits; Ralf-Thorsten Hoffmann; Sofia Gourtsoyianni; Regina Beets-Tan; Emanuele Neri; Nandita M deSouza; Christophe M Deroose; Caroline Caramella Journal: Front Oncol Date: 2022-01-10 Impact factor: 6.244