UNLABELLED: There is evidence that physical activity may reduce the risk of developing Alzheimer disease and dementia. However, few reports have examined the physical activity-dementia association with objective measures of physical activity. Cardiorespiratory fitness (hereafter called fitness) is an objective reproducible measure of recent physical activity habits. PURPOSE: We sought to determine whether fitness is associated with lower risk for dementia mortality in women and men. METHODS: We followed 14,811 women and 45,078 men, age 20-88 yr at baseline, for an average of 17 yr. All participants completed a preventive health examination at the Cooper Clinic in Dallas, TX, during 1970-2001. Fitness was measured with a maximal treadmill exercise test, with results expressed in maximal METs. The National Death Index identified deaths through 2003. Cox proportional hazards models were used to examine the association between baseline fitness and dementia mortality, adjusting for age, sex, examination year, body mass index, smoking, alcohol use, abnormal ECGs, and health status. RESULTS: There were 164 deaths with dementia listed as the cause during 1,012,125 person-years of exposure. Each 1-MET increase in fitness was associated with a 14% lower adjusted risk of dementia mortality (95% confidence interval (CI) = 6%-22%). With fitness expressed in tertiles, adjusted hazard ratios (HRs) for those in the middle- and high-fitness groups suggest their risk of dementia mortality was less than half that of those in the lowest fitness group (HR = 0.44, CI = 0.26-0.74 and HR = 0.49, CI = 0.26-0.90, respectively). CONCLUSIONS: Greater fitness was associated with lower risk of mortality from dementia in a large cohort of men and women.
UNLABELLED: There is evidence that physical activity may reduce the risk of developing Alzheimer disease and dementia. However, few reports have examined the physical activity-dementia association with objective measures of physical activity. Cardiorespiratory fitness (hereafter called fitness) is an objective reproducible measure of recent physical activity habits. PURPOSE: We sought to determine whether fitness is associated with lower risk for dementia mortality in women and men. METHODS: We followed 14,811 women and 45,078 men, age 20-88 yr at baseline, for an average of 17 yr. All participants completed a preventive health examination at the Cooper Clinic in Dallas, TX, during 1970-2001. Fitness was measured with a maximal treadmill exercise test, with results expressed in maximal METs. The National Death Index identified deaths through 2003. Cox proportional hazards models were used to examine the association between baseline fitness and dementia mortality, adjusting for age, sex, examination year, body mass index, smoking, alcohol use, abnormal ECGs, and health status. RESULTS: There were 164 deaths with dementia listed as the cause during 1,012,125 person-years of exposure. Each 1-MET increase in fitness was associated with a 14% lower adjusted risk of dementia mortality (95% confidence interval (CI) = 6%-22%). With fitness expressed in tertiles, adjusted hazard ratios (HRs) for those in the middle- and high-fitness groups suggest their risk of dementia mortality was less than half that of those in the lowest fitness group (HR = 0.44, CI = 0.26-0.74 and HR = 0.49, CI = 0.26-0.90, respectively). CONCLUSIONS: Greater fitness was associated with lower risk of mortality from dementia in a large cohort of men and women.
Authors: Wojtek J Chodzko-Zajko; David N Proctor; Maria A Fiatarone Singh; Christopher T Minson; Claudio R Nigg; George J Salem; James S Skinner Journal: Med Sci Sports Exerc Date: 2009-07 Impact factor: 5.411
Authors: Xuemei Sui; Michael J LaMonte; James N Laditka; James W Hardin; Nancy Chase; Steven P Hooker; Steven N Blair Journal: JAMA Date: 2007-12-05 Impact factor: 56.272
Authors: Wenfei Zhu; Virginia J Howard; Virginia G Wadley; Brent Hutto; Steven N Blair; John E Vena; Natalie Colabianchi; David Rhodes; Steven P Hooker Journal: J Am Geriatr Soc Date: 2015-12 Impact factor: 5.562
Authors: Elizabeth A Boots; Stephanie A Schultz; Jennifer M Oh; Jordan Larson; Dorothy Edwards; Dane Cook; Rebecca L Koscik; Maritza N Dowling; Catherine L Gallagher; Cynthia M Carlsson; Howard A Rowley; Barbara B Bendlin; Asenath LaRue; Sanjay Asthana; Bruce P Hermann; Mark A Sager; Sterling C Johnson; Ozioma C Okonkwo Journal: Brain Imaging Behav Date: 2015-09 Impact factor: 3.978
Authors: Lena L Law; Kate E Sprecher; Ryan J Dougherty; Dorothy F Edwards; Rebecca L Koscik; Catherine L Gallagher; Cynthia M Carlsson; Henrik Zetterberg; Kaj Blennow; Sanjay Asthana; Mark A Sager; Bruce P Hermann; Sterling C Johnson; Dane B Cook; Barbara B Bendlin; Ozioma C Okonkwo Journal: J Alzheimers Dis Date: 2019 Impact factor: 4.472
Authors: Laura F Defina; Benjamin L Willis; Nina B Radford; Ang Gao; David Leonard; William L Haskell; Myron F Weiner; Jarett D Berry Journal: Ann Intern Med Date: 2013-02-05 Impact factor: 25.391
Authors: Michelle W Voss; Matthew Sutterer; Timothy B Weng; Agnieszka Z Burzynska; Jason Fanning; Elizabeth Salerno; Neha P Gothe; Diane K Ehlers; Edward McAuley; Arthur F Kramer Journal: J Appl Physiol (1985) Date: 2018-11-01