Wenfei Zhu1, Virginia J Howard2, Virginia G Wadley3, Brent Hutto4, Steven N Blair5, John E Vena6, Natalie Colabianchi7, David Rhodes8, Steven P Hooker1,9. 1. Institute of Sports Biology, Shaanxi Normal University, Shaanxi, China. 2. Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama. 3. Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama. 4. Prevention Research Center, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina. 5. Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina. 6. Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, South Carolina. 7. Institute for Social Research, University of Michigan, Ann Arbor, Michigan. 8. Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama. 9. Exercise and Wellness Program, School of Nutrition and Health Promotion, Arizona State University, Phoenix, Arizona.
Abstract
OBJECTIVES: To examine the relationship between objectively measured physical activity (PA) and cognitive function in white and black older adults. DESIGN: Cross-sectional. SETTING: REasons for Geographic and Racial Differences in Stroke (REGARDS) study. PARTICIPANTS: Older adults who provided valid data from accelerometer and cognitive function tests (N = 7,098). MEASUREMENTS: Accelerometers provided estimates of PA variables for 4 to 7 consecutive days. PA cut-points of 50 counts per minute (cpm) and 1,065 cpm were applied to differentiate between being sedentary and light PA and between light and moderate to vigorous PA (MVPA), respectively. Prevalence of cognitive impairment was defined using the Six-Item Screener (<4/6). Letter fluency, animal fluency, word list learning, and Montreal Cognitive Assessment (orientation and recall) were used to assess memory and executive function. RESULTS: Of 7,098 participants (aged 70.1 ± 8.5, 54.2% female, 31.5% black), 359 (5.1%) had impaired cognition within ±12 months of PA measurement. The average proportion of time spent in MVPA (MVPA%) was 1.4 ± 1.9%. Participants in the highest quartile of MVPA% (~258.3 min/wk) were less likely to be cognitively impaired than those in the lowest quartile (odds ratio = 0.65, 95% confidence interval = 0.43-0.97). MVPA% was also significantly associated with executive function and memory z-scores (P < .001). Similar analyses of proportion of time spent in light PA (LPA%) and sedentary time (ST%) showed no significant associations with cognitive function. CONCLUSION: Higher levels of objectively measured MVPA%, rather than LPA% or ST%, were associated with lower prevalence of cognitive impairment and better performance in memory and executive function in aging people. The amount of MVPA associated with lower prevalence of cognitive impairment is consistent with meeting PA guidelines.
OBJECTIVES: To examine the relationship between objectively measured physical activity (PA) and cognitive function in white and black older adults. DESIGN: Cross-sectional. SETTING: REasons for Geographic and Racial Differences in Stroke (REGARDS) study. PARTICIPANTS: Older adults who provided valid data from accelerometer and cognitive function tests (N = 7,098). MEASUREMENTS: Accelerometers provided estimates of PA variables for 4 to 7 consecutive days. PA cut-points of 50 counts per minute (cpm) and 1,065 cpm were applied to differentiate between being sedentary and light PA and between light and moderate to vigorous PA (MVPA), respectively. Prevalence of cognitive impairment was defined using the Six-Item Screener (<4/6). Letter fluency, animal fluency, word list learning, and Montreal Cognitive Assessment (orientation and recall) were used to assess memory and executive function. RESULTS: Of 7,098 participants (aged 70.1 ± 8.5, 54.2% female, 31.5% black), 359 (5.1%) had impaired cognition within ±12 months of PA measurement. The average proportion of time spent in MVPA (MVPA%) was 1.4 ± 1.9%. Participants in the highest quartile of MVPA% (~258.3 min/wk) were less likely to be cognitively impaired than those in the lowest quartile (odds ratio = 0.65, 95% confidence interval = 0.43-0.97). MVPA% was also significantly associated with executive function and memory z-scores (P < .001). Similar analyses of proportion of time spent in light PA (LPA%) and sedentary time (ST%) showed no significant associations with cognitive function. CONCLUSION: Higher levels of objectively measured MVPA%, rather than LPA% or ST%, were associated with lower prevalence of cognitive impairment and better performance in memory and executive function in aging people. The amount of MVPA associated with lower prevalence of cognitive impairment is consistent with meeting PA guidelines.
Authors: Virginia J Howard; Mary Cushman; Leavonne Pulley; Camilo R Gomez; Rodney C Go; Ronald J Prineas; Andra Graham; Claudia S Moy; George Howard Journal: Neuroepidemiology Date: 2005-06-29 Impact factor: 3.282
Authors: Mette M Pedersen; Nicole E Holt; Laura Grande; Laura A Kurlinski; Marla K Beauchamp; Dan K Kiely; Janne Petersen; Suzanne Leveille; Jonathan F Bean Journal: J Gerontol A Biol Sci Med Sci Date: 2014-05-05 Impact factor: 6.053
Authors: J C Morris; A Heyman; R C Mohs; J P Hughes; G van Belle; G Fillenbaum; E D Mellits; C Clark Journal: Neurology Date: 1989-09 Impact factor: 9.910
Authors: B M Brown; J J Peiffer; H R Sohrabi; A Mondal; V B Gupta; S R Rainey-Smith; K Taddei; S Burnham; K A Ellis; C Szoeke; C L Masters; D Ames; C C Rowe; R N Martins Journal: Transl Psychiatry Date: 2012-11-20 Impact factor: 6.222
Authors: Wenfei Zhu; Virginia G Wadley; Virginia J Howard; Brent Hutto; Steven N Blair; Steven P Hooker Journal: Med Sci Sports Exerc Date: 2017-01 Impact factor: 5.411
Authors: Shannon D Donofry; Chelsea M Stillman; Jamie L Hanson; Margaret Sheridan; Shufang Sun; Eric B Loucks; Kirk I Erickson Journal: Neurosci Biobehav Rev Date: 2021-10-05 Impact factor: 8.989
Authors: Mehdi Menai; Vincent T van Hees; Alexis Elbaz; Mika Kivimaki; Archana Singh-Manoux; Séverine Sabia Journal: Sci Rep Date: 2017-04-03 Impact factor: 4.379
Authors: Paula Iso-Markku; Katja Waller; Eero Vuoksimaa; Henri Vähä-Ypyä; Noora Lindgren; Kauko Heikkilä; Harri Sievänen; Juha Rinne; Jaakko Kaprio; Urho M Kujala Journal: Alzheimers Dement (N Y) Date: 2018-07-14
Authors: Carrie Huisingh; Cynthia Owsley; Virginia G Wadley; Emily B Levitan; Marguerite R Irvin; Paul MacLennan; Gerald McGwin Journal: Geriatrics (Basel) Date: 2018-03-06