Literature DB >> 21786798

Nitrogen kinetic isotope effects for the monoamine oxidase B-catalyzed oxidation of benzylamine and (1,1-(2)H2)benzylamine: nitrogen rehybridization and CH bond cleavage are not concerted.

Susanna MacMillar1, Dale E Edmondson, Olle Matsson.   

Abstract

Nitrogen kinetic isotope effects for the oxidation of benzylamine and (1,1-(2)H(2))benzylamine by recombinant human monoamine oxidase B show that cleavage of the CH bond is not concerted with rehybridization of the nitrogen atom.

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Year:  2011        PMID： 21786798     DOI： 10.1021/ja205629b

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  12 in total

1.  ²H kinetic isotope effects and pH dependence of catalysis as mechanistic probes of rat monoamine oxidase A: comparisons with the human enzyme.

Authors:  Jin Wang; Dale E Edmondson
Journal:  Biochemistry       Date:  2011-08-16       Impact factor: 3.162

2.  13C kinetic isotope effects on the reaction of a flavin amine oxidase determined from whole molecule isotope effects.

Authors:  José R Tormos; Marina B Suarez; Paul F Fitzpatrick
Journal:  Arch Biochem Biophys       Date:  2016-11-01       Impact factor: 4.013

3.  Computational modeling of the direct hydride transfer mechanism for the MAO catalyzed oxidation of phenethylamine and benzylamine: ONIOM (QM/QM) calculations.

Authors:  Mehmet Ali Akyüz; Safiye Sağ Erdem
Journal:  J Neural Transm (Vienna)       Date:  2013-04-26       Impact factor: 3.575

Review 4.  Kinetics, mechanism, and inhibition of monoamine oxidase.

Authors:  Rona R Ramsay; Alen Albreht
Journal:  J Neural Transm (Vienna)       Date:  2018-03-07       Impact factor: 3.575

5.  Do MAO A and MAO B utilize the same mechanism for the C-H bond cleavage step in catalysis? Evidence suggesting differing mechanisms.

Authors:  R Orru; M Aldeco; D E Edmondson
Journal:  J Neural Transm (Vienna)       Date:  2013-02-16       Impact factor: 3.575

Review 6.  Combining solvent isotope effects with substrate isotope effects in mechanistic studies of alcohol and amine oxidation by enzymes.

Authors:  Paul F Fitzpatrick
Journal:  Biochim Biophys Acta       Date:  2014-10-30

7.  Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus.

Authors:  Brian D Ames; Stuart W Haynes; Xue Gao; Bradley S Evans; Neil L Kelleher; Yi Tang; Christopher T Walsh
Journal:  Biochemistry       Date:  2011-09-19       Impact factor: 3.162

8.  Mechanistic and structural analyses of the roles of active site residues in yeast polyamine oxidase Fms1: characterization of the N195A and D94N enzymes.

Authors:  Mariya S Adachi; Alexander B Taylor; P John Hart; Paul F Fitzpatrick
Journal:  Biochemistry       Date:  2012-10-15       Impact factor: 3.162

9.  Mechanistic study of L-6-hydroxynicotine oxidase by DFT and ONIOM methods.

Authors:  Ibrahim Yildiz; Banu Sizirici Yildiz
Journal:  J Mol Model       Date:  2021-01-28       Impact factor: 1.810

10.  Catalytic Amine Oxidation under Ambient Aerobic Conditions: Mimicry of Monoamine Oxidase B.

Authors:  Alexander T Murray; Myles J H Dowley; Fabienne Pradaux-Caggiano; Amgalanbaatar Baldansuren; Alistair J Fielding; Floriana Tuna; Christopher H Hendon; Aron Walsh; Guy C Lloyd-Jones; Matthew P John; David R Carbery
Journal:  Angew Chem Int Ed Engl       Date:  2015-06-18       Impact factor: 15.336
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