BACKGROUND/AIMS: Sex steroids, such as estrogens, are known to influence endothelial function by their vasodilator action. The aim of this study was to study the relation of puberty and sex steroids with endothelial function using peripheral arterial tonometry (PAT). METHODS: In 89 healthy school boys and girls, we determined height, weight, waist circumference, percent body fat, BMI, BMI z-score, blood pressure (BP), BP percentiles, lipid profile, insulin, and glucose levels after overnight fast. Estrone (E(1)), estradiol (E(2)), DHEAS and E(1)-sulfate were measured using ultrasensitive assays. Participants were divided into 3 pubertal groups on the basis of their estrogen levels: group 1 (Tanner stage I), group 2 (Tanner stages II-III), and group 3 (Tanner stages IV-V). Endothelial function was measured by Endo-PAT 2000® and expressed as PAT index. A higher PAT index represents a higher reactive hyperemia response. RESULTS: The PAT index was lowest at 1.42 ± 0.44 (mean ± SD) in group 1 and significantly increased in group 2 at 1.71 ± 0.35 (p = 0.02) and group 3 at 1.92 ± 0.38 (p < 0.001). The PAT index correlated positively with E(2), DHEAS and age. CONCLUSION: Enhancement of the PAT index was associated with an increment in Tanner stages. The changes in E(2) and DHEAS levels may contribute to increasing endothelial response to shear stress or arterial blood flow.
BACKGROUND/AIMS: Sex steroids, such as estrogens, are known to influence endothelial function by their vasodilator action. The aim of this study was to study the relation of puberty and sex steroids with endothelial function using peripheral arterial tonometry (PAT). METHODS: In 89 healthy school boys and girls, we determined height, weight, waist circumference, percent body fat, BMI, BMI z-score, blood pressure (BP), BP percentiles, lipid profile, insulin, and glucose levels after overnight fast. Estrone (E(1)), estradiol (E(2)), DHEAS and E(1)-sulfate were measured using ultrasensitive assays. Participants were divided into 3 pubertal groups on the basis of their estrogen levels: group 1 (Tanner stage I), group 2 (Tanner stages II-III), and group 3 (Tanner stages IV-V). Endothelial function was measured by Endo-PAT 2000® and expressed as PAT index. A higher PAT index represents a higher reactive hyperemia response. RESULTS: The PAT index was lowest at 1.42 ± 0.44 (mean ± SD) in group 1 and significantly increased in group 2 at 1.71 ± 0.35 (p = 0.02) and group 3 at 1.92 ± 0.38 (p < 0.001). The PAT index correlated positively with E(2), DHEAS and age. CONCLUSION: Enhancement of the PAT index was associated with an increment in Tanner stages. The changes in E(2) and DHEAS levels may contribute to increasing endothelial response to shear stress or arterial blood flow.
Authors: S Kim-Schulze; K A McGowan; S C Hubchak; M C Cid; M B Martin; H K Kleinman; G L Greene; H W Schnaper Journal: Circulation Date: 1996-09-15 Impact factor: 29.690
Authors: E H Lieberman; M D Gerhard; A Uehata; B W Walsh; A P Selwyn; P Ganz; A C Yeung; M A Creager Journal: Ann Intern Med Date: 1994-12-15 Impact factor: 25.391
Authors: Lisa C Hudgins; Vidhya Annavajjhala; Arzu Kovanlikaya; Maura D Frank; Aliza Solomon; Thomas S Parker; Rubin S Cooper Journal: Cardiol Young Date: 2015-05-05 Impact factor: 1.093
Authors: Kara L Marlatt; Julia Steinberger; Donald R Dengel; Alan Sinaiko; Antoinette Moran; Lisa S Chow; Lyn M Steffen; Xia Zhou; Aaron S Kelly Journal: J Pediatr Date: 2013-08-20 Impact factor: 4.406
Authors: Luc Bruyndonckx; Vicky Y Hoymans; Amaryllis H Van Craenenbroeck; Dirk K Vissers; Christiaan J Vrints; José Ramet; Viviane M Conraads Journal: Oxid Med Cell Longev Date: 2013-04-03 Impact factor: 6.543
Authors: Carolina Bastos da Cunha; Fernando Sicuro; Priscila Alves Maranhão; Marcos Antonio Borges; Fátima Z Cyrino; Fernanda Mussi Gazolla; Isabel Rey Madeira; Maria Alice Neves Bordallo; Eliete Bouskela; Luiz Guilherme Kraemer-Aguiar Journal: J Endocr Soc Date: 2017-06-09
Authors: Annabelle L Frost; Katie Suriano; Christina Y L Aye; Paul Leeson; Adam J Lewandowski Journal: Front Pediatr Date: 2021-05-31 Impact factor: 3.418