Aaron S Kelly1, Kara L Marlatt2, Julia Steinberger3, Donald R Dengel2. 1. Department of Pediatrics, University of Minnesota Medical School, and University of Minnesota Amplatz Children's Hospital, Minneapolis, MN 55455, USA; Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Electronic address: kelly105@umn.edu. 2. School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA. 3. Department of Pediatrics, University of Minnesota Medical School, and University of Minnesota Amplatz Children's Hospital, Minneapolis, MN 55455, USA.
Abstract
BACKGROUND: The use of digital reactive hyperemia as a measure of endothelial function among children and adolescents is becoming increasingly common. However, unexpected observations of low reactive hyperemic index values in younger children in our laboratory led us to conduct a study evaluating the influence of age, sex, height, weight, blood pressure, body mass index (BMI), and finger volume on RHI values. METHODS: Endothelial function, measured by digital reactive hyperemia (reactive hyperemic index: RHI) was assessed in 113 children and adolescents (mean age 12.4 ± 3.8 years; 64 males), with 102 also assessed for brachial artery flow-mediated dilation (FMD) using ultrasound imaging. Associations with age, sex, height, weight, systolic and diastolic blood pressure (SBP, DBP), BMI, and finger volume were evaluated. RESULTS: Using GLM regression, age (β = 0.03, P = 0.014) and SBP (β = 0.015, P = 0.004) were significantly associated with RHI. No measures were associated with FMD. In the subset of individuals with measured finger volume, age (β = 0.025, P = 0.037) was the only measure significantly associated with log RHI. Similarly, no measures were associated with FMD. CONCLUSION: Younger age is associated with lower RHI but not lower FMD among children and adolescents. These findings call into question the validity and usefulness of digital reactive hyperemia as a method to quantify endothelial function among younger children.
BACKGROUND: The use of digital reactive hyperemia as a measure of endothelial function among children and adolescents is becoming increasingly common. However, unexpected observations of low reactive hyperemic index values in younger children in our laboratory led us to conduct a study evaluating the influence of age, sex, height, weight, blood pressure, body mass index (BMI), and finger volume on RHI values. METHODS: Endothelial function, measured by digital reactive hyperemia (reactive hyperemic index: RHI) was assessed in 113 children and adolescents (mean age 12.4 ± 3.8 years; 64 males), with 102 also assessed for brachial artery flow-mediated dilation (FMD) using ultrasound imaging. Associations with age, sex, height, weight, systolic and diastolic blood pressure (SBP, DBP), BMI, and finger volume were evaluated. RESULTS: Using GLM regression, age (β = 0.03, P = 0.014) and SBP (β = 0.015, P = 0.004) were significantly associated with RHI. No measures were associated with FMD. In the subset of individuals with measured finger volume, age (β = 0.025, P = 0.037) was the only measure significantly associated with log RHI. Similarly, no measures were associated with FMD. CONCLUSION: Younger age is associated with lower RHI but not lower FMD among children and adolescents. These findings call into question the validity and usefulness of digital reactive hyperemia as a method to quantify endothelial function among younger children.
Authors: H C McGill; C A McMahan; A W Zieske; G D Sloop; J V Walcott; D A Troxclair; G T Malcom; R E Tracy; M C Oalmann; J P Strong Journal: Arterioscler Thromb Vasc Biol Date: 2000-08 Impact factor: 8.311
Authors: H C McGill; C A McMahan; A W Zieske; R E Tracy; G T Malcom; E E Herderick; J P Strong Journal: Circulation Date: 2000-07-25 Impact factor: 29.690
Authors: Aaron S Kelly; Rachel J Wetzsteon; Daniel R Kaiser; Julia Steinberger; Alan J Bank; Donald R Dengel Journal: J Pediatr Date: 2004-12 Impact factor: 4.406
Authors: Piero O Bonetti; Geralyn M Pumper; Stuart T Higano; David R Holmes; Jeffrey T Kuvin; Amir Lerman Journal: J Am Coll Cardiol Date: 2004-12-07 Impact factor: 24.094
Authors: Julian P J Halcox; William H Schenke; Gloria Zalos; Rita Mincemoyer; Abhiram Prasad; Myron A Waclawiw; Khaled R A Nour; Arshed A Quyyumi Journal: Circulation Date: 2002-08-06 Impact factor: 29.690
Authors: D S Celermajer; K E Sorensen; V M Gooch; D J Spiegelhalter; O I Miller; I D Sullivan; J K Lloyd; J E Deanfield Journal: Lancet Date: 1992-11-07 Impact factor: 79.321
Authors: Henry C McGill; C Alex McMahan; Edward E Herderick; Arthur W Zieske; Gray T Malcom; Richard E Tracy; Jack P Strong Journal: Circulation Date: 2002-06-11 Impact factor: 29.690
Authors: Yanina Zócalo; Marco Marotta; Victoria García-Espinosa; Santiago Curcio; Pedro Chiesa; Gustavo Giachetto; Daniel Bia Journal: High Blood Press Cardiovasc Prev Date: 2017-05-15
Authors: M Kreslová; A Sýkorová; R Bittenglová; J Schwarz; R Pomahačová; P Jehlička; J Kobr; L Trefil; J Sýkora Journal: Physiol Res Date: 2021-10-30 Impact factor: 1.881