Literature DB >> 21769094

Chemical probes: sharpen your epigenetic tools.

Alexander-Thomas Hauser1, Manfred Jung.   

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Year:  2011        PMID： 21769094     DOI： 10.1038/nchembio.615

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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  10 in total

1.  Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.

Authors:  Stefan Kubicek; Roderick J O'Sullivan; E Michael August; Eugene R Hickey; Qiang Zhang; Miguel L Teodoro; Stephen Rea; Karl Mechtler; Jennifer A Kowalski; Carol Ann Homon; Terence A Kelly; Thomas Jenuwein
Journal:  Mol Cell       Date:  2007-02-09       Impact factor: 17.970

2.  A combined chemical and genetic approach for the generation of induced pluripotent stem cells.

Authors:  Yan Shi; Jeong Tae Do; Caroline Desponts; Heung Sik Hahm; Hans R Schöler; Sheng Ding
Journal:  Cell Stem Cell       Date:  2008-06-05       Impact factor: 24.633

Review 3.  Protein methyltransferases as a target class for drug discovery.

Authors:  Robert A Copeland; Michael E Solomon; Victoria M Richon
Journal:  Nat Rev Drug Discov       Date:  2009-09       Impact factor: 84.694

4.  The art of the chemical probe.

Authors:  Stephen V Frye
Journal:  Nat Chem Biol       Date:  2010-03       Impact factor: 15.040

5.  Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.

Authors:  Makoto Tachibana; Jun Ueda; Mikiko Fukuda; Naoki Takeda; Tsutomu Ohta; Hiroko Iwanari; Toshiko Sakihama; Tatsuhiko Kodama; Takao Hamakubo; Yoichi Shinkai
Journal:  Genes Dev       Date:  2005-03-17       Impact factor: 11.361

6.  A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.

Authors:  Masoud Vedadi; Dalia Barsyte-Lovejoy; Feng Liu; Sylvie Rival-Gervier; Abdellah Allali-Hassani; Viviane Labrie; Tim J Wigle; Peter A Dimaggio; Gregory A Wasney; Alena Siarheyeva; Aiping Dong; Wolfram Tempel; Sun-Chong Wang; Xin Chen; Irene Chau; Thomas J Mangano; Xi-Ping Huang; Catherine D Simpson; Samantha G Pattenden; Jacqueline L Norris; Dmitri B Kireev; Ashutosh Tripathy; Aled Edwards; Bryan L Roth; William P Janzen; Benjamin A Garcia; Arturas Petronis; James Ellis; Peter J Brown; Stephen V Frye; Cheryl H Arrowsmith; Jian Jin
Journal:  Nat Chem Biol       Date:  2011-07-10       Impact factor: 15.040

7.  G9a and Glp methylate lysine 373 in the tumor suppressor p53.

Authors:  Jing Huang; Jean Dorsey; Sergei Chuikov; Laura Pérez-Burgos; Xinyue Zhang; Thomas Jenuwein; Danny Reinberg; Shelley L Berger
Journal:  J Biol Chem       Date:  2010-01-29       Impact factor: 5.157

8.  H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM.

Authors:  Min-Wei Chen; Kuo-Tai Hua; Hsin-Jung Kao; Chia-Chun Chi; Lin-Hung Wei; Gunnar Johansson; Shine-Gwo Shiah; Pai-Sheng Chen; Yung-Ming Jeng; Tsu-Yao Cheng; Tsung-Ching Lai; Jeng-Shou Chang; Yi-Hua Jan; Ming-Hsien Chien; Chih-Jen Yang; Ming-Shyan Huang; Michael Hsiao; Min-Liang Kuo
Journal:  Cancer Res       Date:  2010-10-12       Impact factor: 12.701

9.  G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis.

Authors:  Makoto Tachibana; Kenji Sugimoto; Masami Nozaki; Jun Ueda; Tsutomu Ohta; Misao Ohki; Mikiko Fukuda; Naoki Takeda; Hiroyuki Niida; Hiroyuki Kato; Yoichi Shinkai
Journal:  Genes Dev       Date:  2002-07-15       Impact factor: 11.361

10.  Protein lysine methyltransferase G9a acts on non-histone targets.

Authors:  Philipp Rathert; Arunkumar Dhayalan; Marie Murakami; Xing Zhang; Raluca Tamas; Renata Jurkowska; Yasuhiko Komatsu; Yoichi Shinkai; Xiaodong Cheng; Albert Jeltsch
Journal:  Nat Chem Biol       Date:  2008-04-27       Impact factor: 15.040
  10 in total
  2 in total

1.  A method for systematic mapping of protein lysine methylation identifies functions for HP1β in DNA damage response.

Authors:  Huadong Liu; Marek Galka; Eiichiro Mori; Xuguang Liu; Yu-Fen Lin; Ran Wei; Paula Pittock; Courtney Voss; Gurpreet Dhami; Xing Li; Masaaki Miyaji; Gilles Lajoie; Benjamin Chen; Shawn Shun-Cheng Li
Journal:  Mol Cell       Date:  2013-05-23       Impact factor: 17.970

2.  Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.

Authors:  Feng Liu; Dalia Barsyte-Lovejoy; Fengling Li; Yan Xiong; Victoria Korboukh; Xi-Ping Huang; Abdellah Allali-Hassani; William P Janzen; Bryan L Roth; Stephen V Frye; Cheryl H Arrowsmith; Peter J Brown; Masoud Vedadi; Jian Jin
Journal:  J Med Chem       Date:  2013-10-31       Impact factor: 7.446
  2 in total

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