| Literature DB >> 18438403 |
Philipp Rathert1, Arunkumar Dhayalan, Marie Murakami, Xing Zhang, Raluca Tamas, Renata Jurkowska, Yasuhiko Komatsu, Yoichi Shinkai, Xiaodong Cheng, Albert Jeltsch.
Abstract
By methylation of peptide arrays, we determined the specificity profile of the protein methyltransferase G9a. We show that it mostly recognizes an Arg-Lys sequence and that its activity is inhibited by methylation of the arginine residue. Using the specificity profile, we identified new non-histone protein targets of G9a, including CDYL1, WIZ, ACINUS and G9a (automethylation), as well as peptides derived from CSB. We demonstrate potential downstream signaling pathways for methylation of non-histone proteins.Entities:
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Year: 2008 PMID： 18438403 PMCID： PMC2696268 DOI： 10.1038/nchembio.88
Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040