Literature DB >> 21768510

New transposon Tn6133 in methicillin-resistant Staphylococcus aureus ST398 contains vga(E), a novel streptogramin A, pleuromutilin, and lincosamide resistance gene.

Sybille Schwendener1, Vincent Perreten.   

Abstract

A novel streptogramin A, pleuromutilin, and lincosamide resistance determinant, Vga(E), was identified in porcine methicillin-resistant Staphylococcus aureus (MRSA) ST398. The vga(E) gene encoded a 524-amino-acid protein belonging to the ABC transporter family. It was found on a multidrug resistance-conferring transposon, Tn6133, which was comprised of Tn554 with a stably integrated 4,787-bp DNA sequence harboring vga(E). Detection of Tn6133 in several porcine MRSA ST398 isolates and its ability to circularize suggest a potential for dissemination.

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Year:  2011        PMID： 21768510      PMCID： PMC3187003          DOI： 10.1128/AAC.00528-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  28 in total

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Authors:  Margaret C M Smith; Helena M Thorpe
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Journal:  J Mol Biol       Date:  1981-10-15       Impact factor: 5.469

3.  Tn554: isolation and characterization of plasmid insertions.

Authors:  E Murphy; S Phillips; I Edelman; R P Novick
Journal:  Plasmid       Date:  1981-05       Impact factor: 3.466

Review 4.  Phylogenetic and functional classification of ATP-binding cassette (ABC) systems.

Authors:  Philippe Bouige; David Laurent; Linda Piloyan; Elie Dassa
Journal:  Curr Protein Pept Sci       Date:  2002-10       Impact factor: 3.272

5.  The large resolvase TndX is required and sufficient for integration and excision of derivatives of the novel conjugative transposon Tn5397.

Authors:  H Wang; P Mullany
Journal:  J Bacteriol       Date:  2000-12       Impact factor: 3.490

6.  Tn5406, a new staphylococcal transposon conferring resistance to streptogramin a and related compounds including dalfopristin.

Authors:  Julien Haroche; Jeanine Allignet; Névine El Solh
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191

7.  MsrR, a putative cell envelope-associated element involved in Staphylococcus aureus sarA attenuation.

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Journal:  Antimicrob Agents Chemother       Date:  2003-08       Impact factor: 5.191

8.  Transferability of macrolide, lincomycin, and streptogramin resistances between group A, B, and D streptococci, Streptococcus pneumoniae, and Staphylococcus aureus.

Authors:  H W Engel; N Soedirman; J A Rost; W J van Leeuwen; J D van Embden
Journal:  J Bacteriol       Date:  1980-05       Impact factor: 3.490

Review 9.  ATP-binding cassette transporters in bacteria.

Authors:  Amy L Davidson; Jue Chen
Journal:  Annu Rev Biochem       Date:  2004       Impact factor: 23.643

10.  The increase of methicillin-resistant Staphylococcus aureus (MRSA) and the presence of an unusual sequence type ST49 in slaughter pigs in Switzerland.

Authors:  Gudrun Overesch; Sabina Büttner; Alexandra Rossano; Vincent Perreten
Journal:  BMC Vet Res       Date:  2011-06-24       Impact factor: 2.741
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  22 in total

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2.  Characterization of sal(A), a novel gene responsible for lincosamide and streptogramin A resistance in Staphylococcus sciuri.

Authors:  Chloé Hot; Nicolas Berthet; Olivier Chesneau
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Authors:  Elena Gómez-Sanz; Kristina Kadlec; Andrea T Feßler; Myriam Zarazaga; Carmen Torres; Stefan Schwarz
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4.  Asymptomatic carriage of sequence type 398, spa type t571 methicillin-susceptible Staphylococcus aureus in an urban jail: a newly emerging, transmissible pathogenic strain.

Authors:  Michael Z David; Jane Siegel; Franklin D Lowy; Diana Zychowski; Alexis Taylor; Caroline J Lee; Susan Boyle-Vavra; Robert S Daum
Journal:  J Clin Microbiol       Date:  2013-05-08       Impact factor: 5.948

5.  Tn6674 Is a Novel Enterococcal optrA-Carrying Multiresistance Transposon of the Tn554 Family.

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Journal:  Antimicrob Agents Chemother       Date:  2019-08-23       Impact factor: 5.191

Review 6.  Mobile Genetic Elements Associated with Antimicrobial Resistance.

Authors:  Sally R Partridge; Stephen M Kwong; Neville Firth; Slade O Jensen
Journal:  Clin Microbiol Rev       Date:  2018-08-01       Impact factor: 26.132

7.  Low Prevalence of Gram-Positive Isolates Showing Elevated Lefamulin MIC Results during the SENTRY Surveillance Program for 2015-2016 and Characterization of Resistance Mechanisms.

Authors:  Rodrigo E Mendes; Susanne Paukner; Timothy B Doyle; Steven P Gelone; Robert K Flamm; Helio S Sader
Journal:  Antimicrob Agents Chemother       Date:  2019-03-27       Impact factor: 5.191

8.  New shuttle vector-based expression system to generate polyhistidine-tagged fusion proteins in Staphylococcus aureus and Escherichia coli.

Authors:  Sybille Schwendener; Vincent Perreten
Journal:  Appl Environ Microbiol       Date:  2015-03-06       Impact factor: 4.792

9.  Decreased susceptibilities to Retapamulin, Mupirocin, and Chlorhexidine among Staphylococcus aureus isolates causing skin and soft tissue infections in otherwise healthy children.

Authors:  J Chase McNeil; Kristina G Hulten; Sheldon L Kaplan; Edward O Mason
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Review 10.  Lincosamides, Streptogramins, Phenicols, and Pleuromutilins: Mode of Action and Mechanisms of Resistance.

Authors:  Stefan Schwarz; Jianzhong Shen; Kristina Kadlec; Yang Wang; Geovana Brenner Michael; Andrea T Feßler; Birte Vester
Journal:  Cold Spring Harb Perspect Med       Date:  2016-11-01       Impact factor: 6.915
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