Literature DB >> 31209008

Tn6674 Is a Novel Enterococcal optrA-Carrying Multiresistance Transposon of the Tn554 Family.

Dexi Li1, Xing-Yun Li1, Stefan Schwarz2, Mengyan Yang1, Su-Mei Zhang1, Wenbo Hao1, Xiang-Dang Du3.   

Abstract

The novel 12,932-bp nonconjugative multiresistance transposon Tn6674 was identified in the chromosomal DNA of a porcine Enterococcus faecalis strain. Tn6674 belongs to the Tn554 family of transposons. It shares the same arrangement of the transposase genes tnpA, tnpB, and tnpC with Tn554 However, in addition to the Tn554-associated resistance genes spc and erm(A), Tn6674 harbored the resistance genes fexA and optrA Circular forms of Tn6674 were detected and suggest the functional activity of this transposon.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  Enterococcus faecalis; optrAzzm321990; oxazolidinones; phenicols; transposon

Mesh：

Substances：

Year:  2019        PMID： 31209008      PMCID： PMC6709469          DOI： 10.1128/AAC.00809-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  27 in total

1.  Identification of the novel dfrK-carrying transposon Tn559 in a porcine methicillin-susceptible Staphylococcus aureus ST398 strain.

Authors:  Kristina Kadlec; Stefan Schwarz
Journal:  Antimicrob Agents Chemother       Date:  2010-05-24       Impact factor: 5.191

2.  Mutational analysis of att554, the target of the site-specific transposon Tn554.

Authors:  E Murphy; E Reinheimer; L Huwyler
Journal:  Plasmid       Date:  1991-07       Impact factor: 3.466

3.  Analysis of a poxtA- and optrA-co-carrying conjugative multiresistance plasmid from Enterococcus faecalis.

Authors:  Wenbo Hao; Xinxin Shan; Dexi Li; Stefan Schwarz; Su-Mei Zhang; Xin-Sheng Li; Xiang-Dang Du
Journal:  J Antimicrob Chemother       Date:  2019-07-01       Impact factor: 5.790

4.  Evolving oxazolidinone resistance mechanisms in a worldwide collection of enterococcal clinical isolates: results from the SENTRY Antimicrobial Surveillance Program.

Authors:  L M Deshpande; M Castanheira; R K Flamm; R E Mendes
Journal:  J Antimicrob Chemother       Date:  2018-09-01       Impact factor: 5.790

5.  Florfenicol-chloramphenicol exporter gene fexA is part of the novel transposon Tn558.

Authors:  Corinna Kehrenberg; Stefan Schwarz
Journal:  Antimicrob Agents Chemother       Date:  2005-02       Impact factor: 5.191

6.  Distribution of the optrA gene in Enterococcus isolates at a tertiary care hospital in China.

Authors:  Wanqing Zhou; Shuo Gao; Hongjing Xu; Zhifeng Zhang; Fei Chen; Han Shen; Chunni Zhang
Journal:  J Glob Antimicrob Resist       Date:  2019-01-11       Impact factor: 4.035

7.  Co-location of the oxazolidinone resistance genes optrA and cfr on a multiresistance plasmid from Staphylococcus sciuri.

Authors:  Dexi Li; Yang Wang; Stefan Schwarz; Jiachang Cai; Run Fan; Jun Li; Andrea T Feßler; Rong Zhang; Congming Wu; Jianzhong Shen
Journal:  J Antimicrob Chemother       Date:  2016-03-06       Impact factor: 5.790

8.  Transposition of Tn554 does not generate a target duplication.

Authors:  E Murphy; S Löfdahl
Journal:  Nature       Date:  1984 Jan 19-25       Impact factor: 49.962

9.  Transposon Tn554: complete nucleotide sequence and isolation of transposition-defective and antibiotic-sensitive mutants.

Authors:  E Murphy; L Huwyler; M do C de Freire Bastos
Journal:  EMBO J       Date:  1985-12-01       Impact factor: 11.598

10.  Novel multiresistance cfr plasmids in linezolid-resistant methicillin-resistant Staphylococcus epidermidis and vancomycin-resistant Enterococcus faecium (VRE) from a hospital outbreak: co-location of cfr and optrA in VRE.

Authors:  Alexandros Lazaris; David C Coleman; Angela M Kearns; Bruno Pichon; Peter M Kinnevey; Megan R Earls; Breida Boyle; Brian O'Connell; Gráinne I Brennan; Anna C Shore
Journal:  J Antimicrob Chemother       Date:  2017-12-01       Impact factor: 5.790
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  10 in total

1.  Transferable Resistance Gene optrA in Enterococcus faecalis from Swine in Brazil.

Authors:  Lara M Almeida; François Lebreton; Anthony Gaca; Paulo M Bispo; Jose T Saavedra; Rodrigo N Calumby; Luciano M Grillo; Ticiano G Nascimento; Pedro H Filsner; Andrea M Moreno; Michael S Gilmore
Journal:  Antimicrob Agents Chemother       Date:  2020-05-21       Impact factor: 5.191

2.  Tn560, a Novel Tn554 Family Transposon from Porcine Methicillin-Resistant Staphylococcus aureus ST398, Carries a Multiresistance Gene Cluster Comprising a Novel spc Gene Variant and the Genes lsa(E) and lnu(B).

Authors:  Xing Ji; Henrike Krüger; Yaxin Wang; Andrea T Feßler; Yang Wang; Stefan Schwarz; Congming Wu
Journal:  Antimicrob Agents Chemother       Date:  2022-03-22       Impact factor: 5.938

3.  [National surveillance of clinical isolates of Enterococcus faecalis resistant to linezolid carrying the optrA gene in Colombia, 2014-2019].

Authors:  Sandra Yamile Saavedra; Johan Fabian Bernal; Efrain Montilla-Escudero; German Torres; Mabel Karina Rodríguez; Andrea Melissa Hidalgo; María Victoria Ovalle; Sandra Rivera; Enrique Perez-Gutierrez; Carolina Duarte
Journal:  Rev Panam Salud Publica       Date:  2020-09-22

4.  Emergence of optrA-Mediated Linezolid Resistance in Enterococcus faecium: A Molecular Investigation in a Tertiary Hospital of Southwest China from 2014-2018.

Authors:  Miao Yi; Jiaqi Zou; Jinxin Zhao; Yu Tang; Yaling Yuan; Bingxue Yang; Jinzhu Huang; Peiwen Xia; Yun Xia
Journal:  Infect Drug Resist       Date:  2022-01-04       Impact factor: 4.003

5.  TnCentral: a Prokaryotic Transposable Element Database and Web Portal for Transposon Analysis.

Authors:  Karen Ross; Alessandro M Varani; Erik Snesrud; Hongzhan Huang; Danillo Oliveira Alvarenga; Jian Zhang; Cathy Wu; Patrick McGann; Mick Chandler
Journal:  mBio       Date:  2021-09-14       Impact factor: 7.867

6.  Sentinel Surveillance Reveals Emerging Daptomycin-Resistant ST736 Enterococcus faecium and Multiple Mechanisms of Linezolid Resistance in Enterococci in the United States.

Authors:  Amy S Gargis; Lori M Spicer; Alyssa G Kent; Wenming Zhu; Davina Campbell; Gillian McAllister; Thomas O Ewing; Valerie Albrecht; Valerie A Stevens; Mili Sheth; Jasmine Padilla; Dhwani Batra; J Kristie Johnson; Alison Laufer Halpin; J Kamile Rasheed; Christopher A Elkins; Maria Karlsson; Joseph D Lutgring
Journal:  Front Microbiol       Date:  2022-02-01       Impact factor: 5.640

7.  Presence of optrA-mediated linezolid resistance in multiple lineages and plasmids of Enterococcus faecalis revealed by long read sequencing.

Authors:  Martin P McHugh; Benjamin J Parcell; Kerry A Pettigrew; Geoff Toner; Elham Khatamzas; Noha El Sakka; Anne Marie Karcher; Joanna Walker; Robert Weir; Danièle Meunier; Katie L Hopkins; Neil Woodford; Kate E Templeton; Stephen H Gillespie; Matthew T G Holden
Journal:  Microbiology (Reading)       Date:  2022-02       Impact factor: 2.777

8.  Mobile Oxazolidinone Resistance Genes in Gram-Positive and Gram-Negative Bacteria.

Authors:  Stefan Schwarz; Wanjiang Zhang; Xiang-Dang Du; Henrike Krüger; Andrea T Feßler; Shizhen Ma; Yao Zhu; Congming Wu; Jianzhong Shen; Yang Wang
Journal:  Clin Microbiol Rev       Date:  2021-06-02       Impact factor: 50.129

9.  Comparative genomics of global optrA-carrying Enterococcus faecalis uncovers a common chromosomal hotspot for optrA acquisition within a diversity of core and accessory genomes.

Authors:  Ana R Freitas; Ana P Tedim; Carla Novais; Val F Lanza; Luísa Peixe
Journal:  Microb Genom       Date:  2020-03-09

10.  Molecular characteristics of optrA-carrying Enterococcus faecalis from chicken meat in South Korea.

Authors:  Sunghyun Yoon; Se Hyun Son; Yeong Bin Kim; Kwang Won Seo; Young Ju Lee
Journal:  Poult Sci       Date:  2020-09-12       Impact factor: 3.352
  10 in total

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