Literature DB >> 21763599

Can a systems perspective help us appreciate the biological meaning of small effects?

Hana El-Samad1, Hiten D Madhani.   

Abstract

The study of dramatic phenotypes has been pivotal to elucidating biological mechanisms. Effectively approaching low-magnitude quantitative phenotypes, a common outcome of systematic loss-of-function studies, will be critical for understanding how individual components of cells interact to generate functioning systems.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21763599      PMCID： PMC3615985          DOI： 10.1016/j.devcel.2011.06.005

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  14 in total

1.  Multiple phosphorylation sites confer reproducibility of the rod's single-photon responses.

Authors:  Thuy Doan; Ana Mendez; Peter B Detwiler; Jeannie Chen; Fred Rieke
Journal:  Science       Date:  2006-07-28       Impact factor: 47.728

Review 2.  Microbial cell individuality and the underlying sources of heterogeneity.

Authors:  Simon V Avery
Journal:  Nat Rev Microbiol       Date:  2006-08       Impact factor: 60.633

Review 3.  Living with noisy genes: how cells function reliably with inherent variability in gene expression.

Authors:  Narendra Maheshri; Erin K O'Shea
Journal:  Annu Rev Biophys Biomol Struct       Date:  2007

4.  Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast.

Authors:  Adam M Deutschbauer; Daniel F Jaramillo; Michael Proctor; Jochen Kumm; Maureen E Hillenmeyer; Ronald W Davis; Corey Nislow; Guri Giaever
Journal:  Genetics       Date:  2005-02-16       Impact factor: 4.562

5.  Single-cell origin of mouse hemopoietic colonies expressing multiple lineages in variable combinations.

Authors:  T Suda; J Suda; M Ogawa
Journal:  Proc Natl Acad Sci U S A       Date:  1983-11       Impact factor: 11.205

6.  Red blood cell distribution width and 1-year mortality in acute heart failure.

Authors:  Roland R J van Kimmenade; Asim A Mohammed; Shanmugam Uthamalingam; Peter van der Meer; G Michael Felker; James L Januzzi
Journal:  Eur J Heart Fail       Date:  2009-12-20       Impact factor: 15.534

7.  Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise.

Authors:  John R S Newman; Sina Ghaemmaghami; Jan Ihmels; David K Breslow; Matthew Noble; Joseph L DeRisi; Jonathan S Weissman
Journal:  Nature       Date:  2006-05-14       Impact factor: 49.962

8.  A general lack of compensation for gene dosage in yeast.

Authors:  Michael Springer; Jonathan S Weissman; Marc W Kirschner
Journal:  Mol Syst Biol       Date:  2010-05-11       Impact factor: 11.429

9.  Coordinate control of gene expression noise and interchromosomal interactions in a MAP kinase pathway.

Authors:  Emma McCullagh; Anupama Seshan; Hana El-Samad; Hiten D Madhani
Journal:  Nat Cell Biol       Date:  2010-09-19       Impact factor: 28.824

10.  Population context determines cell-to-cell variability in endocytosis and virus infection.

Authors:  Berend Snijder; Raphael Sacher; Pauli Rämö; Eva-Maria Damm; Prisca Liberali; Lucas Pelkmans
Journal:  Nature       Date:  2009-08-26       Impact factor: 49.962
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  1 in total

1.  The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3.

Authors:  Mareike Albert; Sandra U Schmitz; Susanne M Kooistra; Martina Malatesta; Cristina Morales Torres; Jens C Rekling; Jens V Johansen; Iratxe Abarrategui; Kristian Helin
Journal:  PLoS Genet       Date:  2013-04-18       Impact factor: 5.917
  1 in total

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