Literature DB >> 2176082

Anti-oxidant defences and peroxidation in liver and brain of aged rats.

G Barja de Quiroga1, R Pérez-Campo, M López Torres.   

Abstract

Old rats (28 months), when compared with young adults (9 months), did not show differences in activities of superoxide dismutase (SOD) or selenium-dependent and -independent glutathione peroxidases (GPx), or in levels of GSH, GSSG, GSSG/GSH and endogenous peroxidation in liver and brain. Rates of stimulated peroxidation in vitro were decreased in the livers of old rats. Old animals showed decreased levels of hepatic catalase and glutathione reductase. Nevertheless, when enzyme activities were referred to cytochrome oxidase activity these decreases disappeared, and GPx and SOD (brain) were even increased in old rats.

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Year:  1990        PMID： 2176082      PMCID： PMC1149684          DOI： 10.1042/bj2720247

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  29 in total

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Authors:  T J Player; D J Mills; A A Horton
Journal:  Biochem Biophys Res Commun       Date:  1977-10-24       Impact factor: 3.575

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Authors:  F Paoletti; D Aldinucci; A Mocali; A Caparrini
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Authors:  M E Spearman; K C Leibman
Journal:  Biochem Pharmacol       Date:  1984-04-15       Impact factor: 5.858

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Authors:  J Vitorica; A Machado; J Satrústegui
Journal:  J Neurochem       Date:  1984-02       Impact factor: 5.372

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Authors:  K J Davies; A T Quintanilha; G A Brooks; L Packer
Journal:  Biochem Biophys Res Commun       Date:  1982-08-31       Impact factor: 3.575

6.  Differential changes in superoxide dismutase activity in brain and liver of old rats and mice.

Authors:  H C Danh; M S Benedetti; P Dostert
Journal:  J Neurochem       Date:  1983-04       Impact factor: 5.372

7.  Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine.

Authors:  O W Griffith
Journal:  Anal Biochem       Date:  1980-07-15       Impact factor: 3.365

8.  Copper-zinc and manganese superoxide dismutase activities in cardiac and skeletal muscles during aging in male rats.

Authors:  C J Lammi-Keefe; P B Swan; P V Hegarty
Journal:  Gerontology       Date:  1984       Impact factor: 5.140

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Authors:  Y Mizuno; K Ohta
Journal:  J Neurochem       Date:  1986-05       Impact factor: 5.372

10.  Changes in ascorbate-induced lipid peroxidation of hepatic rough and smooth microsomes during postnatal development and ageing of rats.

Authors:  T P Devasagayam; C K Pushpendran
Journal:  Mech Ageing Dev       Date:  1986-03       Impact factor: 5.432
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8.  Preventive effect of safranal against oxidative damage in aged male rat brain.

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9.  EVALUATION OF THE EFFECTS OF THE HYDRO-ETHANOLIC ROOT EXTRACT OF ZANTHOXYLUM ZANTHOXYLOIDES ON HEMATOLOGICAL PARAMETERS AND OXIDATIVE STRESS IN CYCLOPHOSPAMIDE TREATED RATS.

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10.  Age-dependent changes of the antioxidant system in rat livers are accompanied by altered MAPK activation and a decline in motor signaling.

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