Literature DB >> 2175878

Characterization of a functional promoter for the human retinoic acid receptor-alpha (hRAR-alpha).

N J Brand1, M Petkovich, P Chambon.   

Abstract

The three retinoic acid receptors RAR-alpha, beta and gamma are thought to mediate the effects of RA in vivo. We have determined here the exon organisation in the 5' region of the human RAR-alpha (hRAR-alpha) gene, and have identified its promoter. This promoter drives the expression of promoterless beta-globin or CAT reporter genes when transfected into HeLa, Cos-1 or mouse embryonal carcinoma (EC) P19.6 cells in culture. There are no TATA or CCAAT-box elements in this promoter, which appears to belong to the class of promoters made up of an initiator element preceded by several putative binding sites for the transcription factor Sp1. In addition, the hRAR-alpha promoter region contains a number of sequences that are similar to known enhancer elements. Notably, the hRAR-alpha promoter contains a sequence identical to a binding site for the Krox-20 transcription factors, a zinc finger-containing protein which is thought to play a role in the early development of the mouse central nervous system.

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Year:  1990        PMID： 2175878      PMCID： PMC332734          DOI： 10.1093/nar/18.23.6799

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  52 in total

1.  CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements.

Authors:  B Luckow; G Schütz
Journal:  Nucleic Acids Res       Date:  1987-07-10       Impact factor: 16.971

Review 2.  A human retinoic acid receptor which belongs to the family of nuclear receptors.

Authors:  M Petkovich; N J Brand; A Krust; P Chambon
Journal:  Nature       Date:  1987 Dec 3-9       Impact factor: 49.962

3.  Identification of a receptor for the morphogen retinoic acid.

Authors:  V Giguere; E S Ong; P Segui; R M Evans
Journal:  Nature       Date:  1987 Dec 17-23       Impact factor: 49.962

4.  The 5' untranslated sequence of the c-sis/platelet-derived growth factor 2 transcript is a potent translational inhibitor.

Authors:  C D Rao; M Pech; K C Robbins; S A Aaronson
Journal:  Mol Cell Biol       Date:  1988-01       Impact factor: 4.272

5.  RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression.

Authors:  M B Shapiro; P Senapathy
Journal:  Nucleic Acids Res       Date:  1987-09-11       Impact factor: 16.971

6.  Embryology: we have a morphogen!

Authors:  J M Slack
Journal:  Nature       Date:  1987 Jun 18-24       Impact factor: 49.962

7.  Functional domains of the human estrogen receptor.

Authors:  V Kumar; S Green; G Stack; M Berry; J R Jin; P Chambon
Journal:  Cell       Date:  1987-12-24       Impact factor: 41.582

8.  Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma.

Authors:  A Dejean; L Bougueleret; K H Grzeschik; P Tiollais
Journal:  Nature       Date:  1986 Jul 3-9       Impact factor: 49.962

9.  Identification and spatial distribution of retinoids in the developing chick limb bud.

Authors:  C Thaller; G Eichele
Journal:  Nature       Date:  1987 Jun 18-24       Impact factor: 49.962

10.  Characterization of neurotransmitter phenotype during neuronal differentiation of embryonal carcinoma cells.

Authors:  S Sharma; M F Notter
Journal:  Dev Biol       Date:  1988-02       Impact factor: 3.582
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  18 in total

1.  At least three promoters direct expression of the mouse glucocorticoid receptor gene.

Authors:  U Strähle; A Schmidt; G Kelsey; A F Stewart; T J Cole; W Schmid; G Schütz
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-01       Impact factor: 11.205

2.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1991-03-11       Impact factor: 16.971

3.  Retinoic acid receptor alpha1 variants, RARalpha1DeltaB and RARalpha1DeltaBC, define a new class of nuclear receptor isoforms.

Authors:  A Parrado; G Despouy; R Kraïba; C Le Pogam; S Dupas; M Choquette; M Robledo; J Larghero; H Bui; I Le Gall; C Rochette-Egly; C Chomienne; R A Padua
Journal:  Nucleic Acids Res       Date:  2001-12-15       Impact factor: 16.971

Review 4.  An analysis of vertebrate mRNA sequences: intimations of translational control.

Authors:  M Kozak
Journal:  J Cell Biol       Date:  1991-11       Impact factor: 10.539

5.  Cloning and characterization of the mouse vitamin D receptor promoter.

Authors:  F Jehan; H F DeLuca
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-16       Impact factor: 11.205

6.  Variant-type PML-RAR(alpha) fusion transcript in acute promyelocytic leukemia: use of a cryptic coding sequence from intron 2 of the RAR(alpha) gene and identification of a new clinical subtype resistant to retinoic acid therapy.

Authors:  Bai-Wei Gu; Hui Xiong; Yan Zhou; Bing Chen; Li Wang; Shuo Dong; Zhi-Yuan Yu; Ling-Feng Lu; Ming Zhong; Hai-Feng Yin; Gen-Feng Zhu; Wei Huang; Shuang-Xi Ren; Robert E Gallagher; Samuel Waxman; Guo-Qiang Chen; Zhu-Gang Wang; Zhu Chen; Gang Fu; Sai-Juan Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-28       Impact factor: 11.205

7.  Mouse retinoic acid receptor alpha 2 isoform is transcribed from a promoter that contains a retinoic acid response element.

Authors:  P Leroy; H Nakshatri; P Chambon
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-15       Impact factor: 11.205

8.  Genomic organization of the human thyroid hormone receptor alpha (c-erbA-1) gene.

Authors:  V Laudet; A Begue; C Henry-Duthoit; A Joubel; P Martin; D Stehelin; S Saule
Journal:  Nucleic Acids Res       Date:  1991-03-11       Impact factor: 16.971

9.  Characterization of a fusion cDNA (RARA/myl) transcribed from the t(15;17) translocation breakpoint in acute promyelocytic leukemia.

Authors:  K S Chang; S A Stass; D T Chu; L L Deaven; J M Trujillo; E J Freireich
Journal:  Mol Cell Biol       Date:  1992-02       Impact factor: 4.272

10.  Cryptic promoter activity within the backbone of a plasmid commonly used to prepare promoter/reporter gene constructs.

Authors:  E Rosfjord; K Lamb; A Rizzino
Journal:  In Vitro Cell Dev Biol Anim       Date:  1994-07       Impact factor: 2.416
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