OBJECTIVE: Folate is involved in the one-carbon metabolism that plays an essential role in the synthesis, repair, and methylation of DNA. We examined whether child's germline genetic variation in the folate pathway is associated with childhood acute lymphoblastic leukemia (ALL), and whether periconception maternal folate and alcohol intake modify the risk. METHODS: Seventy-six single nucleotide polymorphisms (SNPs), including 66 haplotype-tagging SNPs in 10 genes (CBS, DHFR, FOLH1, MTHFD1, MTHFR, MTR, MTRR, SHMT1, SLC19A1, and TYMS), were genotyped in 377 ALL cases and 448 controls. Log-additive associations between genotypes and ALL risk were adjusted for age, sex, Hispanic ethnicity (when appropriate), and maternal race. RESULTS: Single and haplotype SNPs analyses showed statistically significant associations between SNPs located in (or adjacent to) CBS, MTRR, TYMS/ENOFS, and childhood ALL. Many regions of CBS were associated with childhood ALL in Hispanics and non-Hispanics (p < 0.01). Levels of maternal folate intake modified associations with SNPs in CBS, MTRR, and TYMS. CONCLUSION: Our data suggest the importance of genetic variability in the folate pathway and childhood ALL risk.
OBJECTIVE:Folate is involved in the one-carbon metabolism that plays an essential role in the synthesis, repair, and methylation of DNA. We examined whether child's germline genetic variation in the folate pathway is associated with childhood acute lymphoblastic leukemia (ALL), and whether periconception maternal folate and alcohol intake modify the risk. METHODS: Seventy-six single nucleotide polymorphisms (SNPs), including 66 haplotype-tagging SNPs in 10 genes (CBS, DHFR, FOLH1, MTHFD1, MTHFR, MTR, MTRR, SHMT1, SLC19A1, and TYMS), were genotyped in 377 ALL cases and 448 controls. Log-additive associations between genotypes and ALL risk were adjusted for age, sex, Hispanic ethnicity (when appropriate), and maternal race. RESULTS: Single and haplotype SNPs analyses showed statistically significant associations between SNPs located in (or adjacent to) CBS, MTRR, TYMS/ENOFS, and childhood ALL. Many regions of CBS were associated with childhood ALL in Hispanics and non-Hispanics (p < 0.01). Levels of maternal folate intake modified associations with SNPs in CBS, MTRR, and TYMS. CONCLUSION: Our data suggest the importance of genetic variability in the folate pathway and childhood ALL risk.
Authors: Maureen A Murtaugh; Karen Curtin; Carol Sweeney; Roger K Wolff; Richard Holubkov; Bette J Caan; Martha L Slattery Journal: Cancer Causes Control Date: 2007-01-23 Impact factor: 2.506
Authors: Margaret A McDowell; David A Lacher; Christine M Pfeiffer; Joseph Mulinare; Mary F Picciano; Jeanne I Rader; Elizabeth A Yetley; Jocelyn Kennedy-Stephenson; Clifford L Johnson Journal: NCHS Data Brief Date: 2008-05
Authors: Marilyn L Kwan; Christopher D Jensen; Gladys Block; Mark L Hudes; Lisa W Chu; Patricia A Buffler Journal: Public Health Rep Date: 2009 Jul-Aug Impact factor: 2.792
Authors: Robert de Jonge; Wim J E Tissing; Jan Hendrik Hooijberg; Gerrit Jansen; Gertjan J L Kaspers; Jan Lindemans; Godefridus J Peters; Rob Pieters Journal: Blood Date: 2008-11-19 Impact factor: 22.113
Authors: Tracy J Lightfoot; W Thomas Johnston; Dan Painter; Jill Simpson; Eve Roman; Chris F Skibola; Martyn T Smith; James M Allan; G Malcolm Taylor Journal: Blood Date: 2010-01-25 Impact factor: 22.113
Authors: Hui Lv; Shao-Yan Hu; Zhi-Zuo Du; Zong Zhai; Lan Cao; Yi-Na Sun; Jun Lu; Jie Li; Hai-Long He; Yi-Huan Chai; Yi Wang Journal: Int J Clin Exp Pathol Date: 2018-03-01
Authors: Rafaela Montalvão-de-Azevedo; Gisele M Vasconcelos; Fernando R Vargas; Luiz Claudio Thuler; Maria S Pombo-de-Oliveira; Beatriz de Camargo Journal: Genet Test Mol Biomarkers Date: 2014-12-23
Authors: Todd P Whitehead; Catherine Metayer; Joseph L Wiemels; Amanda W Singer; Mark D Miller Journal: Curr Probl Pediatr Adolesc Health Care Date: 2016-10
Authors: Amanda W Singer; Steve Selvin; Gladys Block; Carla Golden; Suzan L Carmichael; Catherine Metayer Journal: Cancer Causes Control Date: 2016-06-13 Impact factor: 2.506
Authors: Philip J Lupo; Darryl Nousome; Kala Y Kamdar; M Fatih Okcu; Michael E Scheurer Journal: Cancer Causes Control Date: 2012-09-01 Impact factor: 2.506