| Literature DB >> 19651439 |
Allen Eng-Juh Yeoh1, Yi Lu, Jason Yong-Sheng Chan, Yiong Huak Chan, Hany Ariffin, Shirley Kow-Yin Kham, Thuan Chong Quah.
Abstract
To study genetic epidemiology of childhood acute lymphoblastic leukemia (ALL) in the Chinese and Malays, we investigated 10 polymorphisms encoding carcinogen- or folate-metabolism and transport. Sex-adjusted analysis showed NQO1 609CT significantly protects against ALL, whilst MTHFR 677CT confers marginal protection. Interestingly, we observed that NQO1 609CT and MTHFR 1298 C-allele have greater genetic impact in boys than in girls. The combination of SLC19A1 80GA heterozygosity and 3'-TYMS -6bp/-6bp homozygous deletion is associated with reduced ALL risk in Malay boys. Our study has suggested the importance of gender and race in modulating ALL susceptibility via the folate metabolic pathway. Copyright (c) 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 19651439 DOI： 10.1016/j.leukres.2009.07.003
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156