Amanda W Singer1, Steve Selvin2, Gladys Block2, Carla Golden3, Suzan L Carmichael4, Catherine Metayer2. 1. Division of Epidemiology, School of Public Health, University of California, Berkeley, 1995 University Avenue, Suite 460, Berkeley, CA, 94704, USA. amandawsinger@gmail.com. 2. Division of Epidemiology, School of Public Health, University of California, Berkeley, 1995 University Avenue, Suite 460, Berkeley, CA, 94704, USA. 3. Children's Hospital Oakland, Oakland, CA, USA. 4. Division of Neonatology and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Abstract
PURPOSE: Folate, vitamins B12 and B6, riboflavin, and methionine are critical nutrients for the one-carbon metabolism cycle involved in DNA synthesis and epigenetic processes. We examined the association between maternal intake of these nutrients before pregnancy and risk of childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) in a matched case-control study. METHODS: Maternal dietary intake and vitamin supplement use in the year before pregnancy was assessed by food frequency questionnaire for 681 ALL cases, 103 AML cases, and 1076 controls. Principal component analysis was used to construct a variable representing combined nutrient intake, and conditional logistic regression estimated the odds ratio (OR) and 95% confidence interval (CI) for the association of ALL and AML with the principal component and each nutrient. RESULTS: Higher maternal intake of one-carbon metabolism nutrients from food and supplements combined was associated with reduced risk of ALL (OR for one-unit change in the principal component = 0.91, CI 0.84-0.99) and possibly AML (OR for the principal component = 0.83, CI 0.66-1.04). When analyzed separately, intake of supplements high in these nutrients was associated with a reduced risk of ALL in children of Hispanic women only. CONCLUSIONS: In conclusion, these data suggest that higher maternal intake of one-carbon metabolism nutrients may reduce risk of childhood leukemia.
PURPOSE:Folate, vitamins B12 and B6, riboflavin, and methionine are critical nutrients for the one-carbon metabolism cycle involved in DNA synthesis and epigenetic processes. We examined the association between maternal intake of these nutrients before pregnancy and risk of childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) in a matched case-control study. METHODS: Maternal dietary intake and vitamin supplement use in the year before pregnancy was assessed by food frequency questionnaire for 681 ALL cases, 103 AML cases, and 1076 controls. Principal component analysis was used to construct a variable representing combined nutrient intake, and conditional logistic regression estimated the odds ratio (OR) and 95% confidence interval (CI) for the association of ALL and AML with the principal component and each nutrient. RESULTS: Higher maternal intake of one-carbon metabolism nutrients from food and supplements combined was associated with reduced risk of ALL (OR for one-unit change in the principal component = 0.91, CI 0.84-0.99) and possibly AML (OR for the principal component = 0.83, CI 0.66-1.04). When analyzed separately, intake of supplements high in these nutrients was associated with a reduced risk of ALL in children of Hispanic women only. CONCLUSIONS: In conclusion, these data suggest that higher maternal intake of one-carbon metabolism nutrients may reduce risk of childhood leukemia.
Entities:
Keywords:
Cancer risk; Case/control; Epidemiology; Methyl donors; Micronutrients
Authors: Paul F Jacques; Renee Kalmbach; Pamela J Bagley; Giuseppina T Russo; Gail Rogers; Peter W F Wilson; Irwin H Rosenberg; Jacob Selhub Journal: J Nutr Date: 2002-02 Impact factor: 4.798
Authors: Stephen Starko Francis; Steve Selvin; Catherine Metayer; Amelia D Wallace; Vonda Crouse; Theodore B Moore; Joseph L Wiemels; Patricia A Buffler Journal: Cancer Epidemiol Biomarkers Prev Date: 2014-03-11 Impact factor: 4.254
Authors: Sheryl L Rifas-Shiman; Janet W Rich-Edwards; Walter C Willett; Ken P Kleinman; Emily Oken; Matthew W Gillman Journal: Paediatr Perinat Epidemiol Date: 2006-01 Impact factor: 3.980
Authors: Xiaomei Ma; Patricia A Buffler; Joseph L Wiemels; Steve Selvin; Catherine Metayer; Mignon Loh; Monique B Does; John K Wiencke Journal: Cancer Epidemiol Biomarkers Prev Date: 2005-08 Impact factor: 4.254
Authors: Christopher D Jensen; Gladys Block; Patricia Buffler; Xiaomei Ma; Steve Selvin; Stacy Month Journal: Cancer Causes Control Date: 2004-08 Impact factor: 2.506
Authors: Catherine Metayer; Elizabeth Milne; John D Dockerty; Jacqueline Clavel; Maria S Pombo-de-Oliveira; Catharina Wesseling; Logan G Spector; Joachim Schüz; Eleni Petridou; Sameera Ezzat; Bruce K Armstrong; Jérémie Rudant; Sergio Koifman; Peter Kaatsch; Maria Moschovi; Wafaa M Rashed; Steve Selvin; Kathryn McCauley; Rayjean J Hung; Alice Y Kang; Claire Infante-Rivard Journal: Epidemiology Date: 2014-11 Impact factor: 4.822
Authors: Wan Rosmawati Wan Ismail; Raudah Abdul Rahman; Nur Ashiqin Abd Rahman; Azman Atil; Azmawati Mohammed Nawi Journal: J Prev Med Public Health Date: 2019-07-02
Authors: Carolyn F McCabe; Jennifer L LaBarre; Steven E Domino; Marjorie C Treadwell; Ana Baylin; Charles F Burant; Dana C Dolinoy; Vasantha Padmanabhan; Jaclyn M Goodrich Journal: J Nutr Biochem Date: 2022-01-10 Impact factor: 6.048
Authors: Todd P Whitehead; Catherine Metayer; Joseph L Wiemels; Amanda W Singer; Mark D Miller Journal: Curr Probl Pediatr Adolesc Health Care Date: 2016-10