Literature DB >> 21746954

First outbreak of a plasmid-mediated carbapenem-hydrolyzing OXA-48 beta-lactamase in Klebsiella pneumoniae in Spain.

Cristina Pitart1, Mar Solé, Ignasi Roca, Anna Fàbrega, Jordi Vila, Francesc Marco.   

Abstract

Twenty Klebsiella pneumoniae isolates producing OXA-48 were collected from April 2009 to September 2010. Strains were clonally related and coproduced a CTX-M-15 β-lactamase. A conjugative plasmid of circa 70 kb carrying bla(OXA-48) was identified. Eleven isolates showed low-level resistance to carbapenems, whereas nine showed high-level resistance. Decreased expression of OmpK36 was related to high-level resistance to carbapenems. The isolates belonged to sequence type 101 (ST101). This is the first outbreak caused by an OXA-48-producing K. pneumoniae strain in Spain.

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Year:  2011        PMID： 21746954      PMCID： PMC3165339          DOI： 10.1128/AAC.00329-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

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  44 in total

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Journal:  Eur J Clin Microbiol Infect Dis       Date:  2012-09-07       Impact factor: 3.267

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9.  Molecular characterization of blaNDM-5 carried on an IncFII plasmid in an Escherichia coli isolate from a nontraveler patient in Spain.

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10.  LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48.

Authors:  Juan A Vallejo; Marta Martínez-Guitián; Juan C Vázquez-Ucha; Concepción González-Bello; Margarita Poza; John D Buynak; Christopher R Bethel; Robert A Bonomo; German Bou; Alejandro Beceiro
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