Literature DB >> 21744448

Aplysqualenol A binds to the light chain of dynein type 1 (DYNLL1).

Brunilda Vera1, Abimael D Rodríguez, James J La Clair.   

Abstract

A bidirectional affinity system has been developed for the identification of cancer-related natural products and their biological targets. Aplysqualenol A is thus selectively identified as a ligand of the dynein light chain. The use of forward and reverse affinity methods suggests that both small-molecule isolation and target identification can be conducted using conventional molecular biological methods.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2011        PMID： 21744448      PMCID： PMC3582901          DOI： 10.1002/anie.201102546

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  65 in total

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