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Literature DB >> 24279991

Dactyloditerpenol acetate, a new prenylbisabolane-type diterpene from Aplysia dactylomela with significant in vitro anti-neuroinflammatory activity.

Carlos Jiménez-Romero¹, Alejandro M S Mayer², Abimael D Rodríguez³.

Abstract

A new regular diterpene possessing an unusual 1,6-anti-3-methylcyclohex-2-en-1-ol ring system, dactyloditerpenol acetate (1), has been extracted from the tropical sea hare Aplysia dactylomela and its stereostructure elucidated by spectroscopic methods. The absolute configuration of 1 was determined as 1S, 6S, 7R, 10S, and 11R by application of Kishi's method for the assignment of absolute configuration of alcohols. The new diterpene potently inhibited in vitro thromboxane B2 (TXB2) (IC50 0.4μM) and superoxide anion (O2(-)) (IC50 1μM) generation from Escherichia coli lipopolysaccharide (LPS)-activated rat neonatal microglia, with concomitant low short-term toxicity.

Entities: CellLine Chemical Disease Gene Species

Keywords: Aplysia dactylomela; Diterpene; Prenylbisabolane; Tuberculosis; anti-Neuroinflammatory activity

Mesh：

Substances：

Year: 2013 PMID： 24279991 PMCID： PMC4249741 DOI： 10.1016/j.bmcl.2013.11.008

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

30 in total

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8. Effects of caffeine and paracetamol alone or in combination with acetylsalicylic acid on prostaglandin E(2) synthesis in rat microglial cells.

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