| Literature DB >> 21743057 |
Fredrick R Schumacher1, Sonja I Berndt, Afshan Siddiq, Kevin B Jacobs, Zhaoming Wang, Sara Lindstrom, Victoria L Stevens, Constance Chen, Alison M Mondul, Ruth C Travis, Daniel O Stram, Rosalind A Eeles, Douglas F Easton, Graham Giles, John L Hopper, David E Neal, Freddie C Hamdy, Jenny L Donovan, Kenneth Muir, Ali Amin Al Olama, Zsofia Kote-Jarai, Michelle Guy, Gianluca Severi, Henrik Grönberg, William B Isaacs, Robert Karlsson, Fredrik Wiklund, Jianfeng Xu, Naomi E Allen, Gerald L Andriole, Aurelio Barricarte, Heiner Boeing, H Bas Bueno-de-Mesquita, E David Crawford, W Ryan Diver, Carlos A Gonzalez, J Michael Gaziano, Edward L Giovannucci, Mattias Johansson, Loic Le Marchand, Jing Ma, Sabina Sieri, Pär Stattin, Meir J Stampfer, Anne Tjonneland, Paolo Vineis, Jarmo Virtamo, Ulla Vogel, Stephanie J Weinstein, Meredith Yeager, Michael J Thun, Laurence N Kolonel, Brian E Henderson, Demetrius Albanes, Richard B Hayes, Heather Spencer Feigelson, Elio Riboli, David J Hunter, Stephen J Chanock, Christopher A Haiman, Peter Kraft.
Abstract
Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countries and the second leading cause of cancer mortality, yet little is known regarding its etiology and factors that influence clinical outcome. Genome-wide association studies (GWAS) of PrCa have identified at least 30 distinct loci associated with small differences in risk. We conducted a GWAS in 2782 advanced PrCa cases (Gleason grade ≥ 8 or tumor stage C/D) and 4458 controls with 571 243 single nucleotide polymorphisms (SNPs). Based on in silico replication of 4679 SNPs (Stage 1, P < 0.02) in two published GWAS with 7358 PrCa cases and 6732 controls, we identified a new susceptibility locus associated with overall PrCa risk at 2q37.3 (rs2292884, P= 4.3 × 10(-8)). We also confirmed a locus suggested by an earlier GWAS at 12q13 (rs902774, P= 8.6 × 10(-9)). The estimated per-allele odds ratios for these loci (1.14 for rs2292884 and 1.17 for rs902774) did not differ between advanced and non-advanced PrCa (case-only test for heterogeneity P= 0.72 and P= 0.61, respectively). Further studies will be needed to assess whether these or other loci are differentially associated with PrCa subtypes.Entities:
Mesh：
Year: 2011 PMID： 21743057 PMCID： PMC3168287 DOI： 10.1093/hmg/ddr295
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150