Literature DB >> 12563560

Confirmation of linkage of prostate cancer aggressiveness with chromosome 19q.

S L Slager1, D J Schaid, J M Cunningham, S K McDonnell, A F Marks, B J Peterson, S J Hebbring, S Anderson, A J French, S N Thibodeau.   

Abstract

Regions on chromosomes 7 and 19 were recently reported to contain susceptibility loci that regulate tumor aggressiveness of prostate cancer. To confirm these findings, we analyzed genome scan data from 161 pedigrees affected with prostate cancer. Using the Gleason score as a quantitative measure of tumor aggressiveness, we regressed the squared trait difference, as well as the mean-corrected cross product, on the estimated proportion of alleles shared identical-by-descent at each marker position. Our results confirm the previous linkage results for chromosome 19q (D19S902, P<.00001). In addition, we report suggestive evidence for linkage on chromosome 4 (D4S403, P=.00012). The results of previous findings, together with our results, provide strong evidence that chromosome 19 harbors a gene for tumor aggressiveness.

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Year:  2003        PMID： 12563560      PMCID： PMC1180252          DOI： 10.1086/368230

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  25 in total

1.  Model-free linkage analysis with covariates confirms linkage of prostate cancer to chromosomes 1 and 4.

Authors:  K A Goddard; J S Witte; B K Suarez; W J Catalona; J M Olson
Journal:  Am J Hum Genet       Date:  2001-04-13       Impact factor: 11.025

2.  Haseman and Elston revisited: the effects of ascertainment and residual familial correlations on power to detect linkage.

Authors:  L J Palmer; K B Jacobs; R C Elston
Journal:  Genet Epidemiol       Date:  2000-12       Impact factor: 2.135

3.  The replication requirement.

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Journal:  Nat Genet       Date:  2001-11       Impact factor: 38.330

4.  Linkage and association studies of prostate cancer susceptibility: evidence for linkage at 8p22-23.

Authors:  J Xu; S L Zheng; G A Hawkins; D A Faith; B Kelly; S D Isaacs; K E Wiley; B Chang ; C M Ewing; P Bujnovszky; J D Carpten; E R Bleecker; P C Walsh; J M Trent; D A Meyers; W B Isaacs
Journal:  Am J Hum Genet       Date:  2001-07-06       Impact factor: 11.025

5.  Merlin--rapid analysis of dense genetic maps using sparse gene flow trees.

Authors:  Gonçalo R Abecasis; Stacey S Cherny; William O Cookson; Lon R Cardon
Journal:  Nat Genet       Date:  2001-12-03       Impact factor: 38.330

6.  Power of regression and maximum likelihood methods to map QTL from sib-pair and DZ twin data.

Authors:  P M Visscher; J L Hopper
Journal:  Ann Hum Genet       Date:  2001-11       Impact factor: 1.670

7.  Family history and the risk of prostate cancer.

Authors:  G D Steinberg; B S Carter; T H Beaty; B Childs; P C Walsh
Journal:  Prostate       Date:  1990       Impact factor: 4.104

8.  Systematic population-based assessment of cancer risk in first-degree relatives of cancer probands.

Authors:  D E Goldgar; D F Easton; L A Cannon-Albright; M H Skolnick
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9.  Is tumor volume an independent predictor of progression following radical prostatectomy? A multivariate analysis of 185 clinical stage B adenocarcinomas of the prostate with 5 years of followup.

Authors:  J I Epstein; M Carmichael; A W Partin; P C Walsh
Journal:  J Urol       Date:  1993-06       Impact factor: 7.450

Review 10.  Genetics of prostate cancer: too many loci, too few genes.

Authors:  E A Ostrander; J L Stanford
Journal:  Am J Hum Genet       Date:  2000-11-07       Impact factor: 11.043
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  24 in total

1.  Genome-wide linkage analysis of 1,233 prostate cancer pedigrees from the International Consortium for Prostate Cancer Genetics using novel sumLINK and sumLOD analyses.

Authors:  G Bryce Christensen; Agnes B Baffoe-Bonnie; Asha George; Isaac Powell; Joan E Bailey-Wilson; John D Carpten; Graham G Giles; John L Hopper; Gianluca Severi; Dallas R English; William D Foulkes; Lovise Maehle; Pal Moller; Ros Eeles; Douglas Easton; Michael D Badzioch; Alice S Whittemore; Ingrid Oakley-Girvan; Chih-Lin Hsieh; Latchezar Dimitrov; Jianfeng Xu; Janet L Stanford; Bo Johanneson; Kerry Deutsch; Laura McIntosh; Elaine A Ostrander; Kathleen E Wiley; Sarah D Isaacs; Patrick C Walsh; William B Isaacs; Stephen N Thibodeau; Shannon K McDonnell; Scott Hebbring; Daniel J Schaid; Ethan M Lange; Kathleen A Cooney; Teuvo L J Tammela; Johanna Schleutker; Thomas Paiss; Christiane Maier; Henrik Grönberg; Fredrik Wiklund; Monica Emanuelsson; James M Farnham; Lisa A Cannon-Albright; Nicola J Camp
Journal:  Prostate       Date:  2010-05-15       Impact factor: 4.104

2.  Genome-wide association study of prostate cancer mortality.

Authors:  Kathryn L Penney; Saumyadipta Pyne; Fredrick R Schumacher; Jennifer A Sinnott; Lorelei A Mucci; Peter L Kraft; Jing Ma; William K Oh; Tobias Kurth; Philip W Kantoff; Edward L Giovannucci; Meir J Stampfer; David J Hunter; Matthew L Freedman
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2010-10-26       Impact factor: 4.254

3.  Tagging SNPs in the kallikrein genes 3 and 2 on 19q13 and their associations with prostate cancer in men of European origin.

Authors:  Prodipto Pal; Huifeng Xi; Guangyun Sun; Ritesh Kaushal; Joshua J Meeks; C Shad Thaxton; Saurav Guha; Carol H Jin; Brian K Suarez; William J Catalona; Ranjan Deka
Journal:  Hum Genet       Date:  2007-06-26       Impact factor: 4.132

4.  High levels of glioma tumor suppressor candidate region gene 1 predicts a poor prognosis for prostate cancer.

Authors:  Xiaoming Ma; Tao Du; Dingjun Zhu; Xianju Chen; Yiming Lai; Wanhua Wu; Qiong Wang; Chunhao Lin; Zean Li; Leyuan Liu; Hai Huang
Journal:  Oncol Lett       Date:  2018-09-24       Impact factor: 2.967

Review 5.  Prostate cancer susceptibility loci: finding the genes.

Authors:  Elanie A Ostrander; Bo Johannesson
Journal:  Adv Exp Med Biol       Date:  2008       Impact factor: 2.622

6.  Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases.

Authors:  Brian T Helfand; Kimberly A Roehl; Phillip R Cooper; Barry B McGuire; Liesel M Fitzgerald; Geraldine Cancel-Tassin; Jean-Nicolas Cornu; Scott Bauer; Erin L Van Blarigan; Xin Chen; David Duggan; Elaine A Ostrander; Mary Gwo-Shu; Zuo-Feng Zhang; Shen-Chih Chang; Somee Jeong; Elizabeth T H Fontham; Gary Smith; James L Mohler; Sonja I Berndt; Shannon K McDonnell; Rick Kittles; Benjamin A Rybicki; Matthew Freedman; Philip W Kantoff; Mark Pomerantz; Joan P Breyer; Jeffrey R Smith; Timothy R Rebbeck; Dan Mercola; William B Isaacs; Fredrick Wiklund; Olivier Cussenot; Stephen N Thibodeau; Daniel J Schaid; Lisa Cannon-Albright; Kathleen A Cooney; Stephen J Chanock; Janet L Stanford; June M Chan; John Witte; Jianfeng Xu; Jeannette T Bensen; Jack A Taylor; William J Catalona
Journal:  Hum Genet       Date:  2015-02-26       Impact factor: 4.132

7.  Genome-wide linkage scan for prostate cancer susceptibility genes in men with aggressive disease: significant evidence for linkage at chromosome 15q12.

Authors:  Ethan M Lange; Lindsey A Ho; Jennifer L Beebe-Dimmer; Yunfei Wang; Elizabeth M Gillanders; Jeffrey M Trent; Leslie A Lange; David P Wood; Kathleen A Cooney
Journal:  Hum Genet       Date:  2006-03-01       Impact factor: 4.132

8.  Genome-wide association study identifies new prostate cancer susceptibility loci.

Authors:  Fredrick R Schumacher; Sonja I Berndt; Afshan Siddiq; Kevin B Jacobs; Zhaoming Wang; Sara Lindstrom; Victoria L Stevens; Constance Chen; Alison M Mondul; Ruth C Travis; Daniel O Stram; Rosalind A Eeles; Douglas F Easton; Graham Giles; John L Hopper; David E Neal; Freddie C Hamdy; Jenny L Donovan; Kenneth Muir; Ali Amin Al Olama; Zsofia Kote-Jarai; Michelle Guy; Gianluca Severi; Henrik Grönberg; William B Isaacs; Robert Karlsson; Fredrik Wiklund; Jianfeng Xu; Naomi E Allen; Gerald L Andriole; Aurelio Barricarte; Heiner Boeing; H Bas Bueno-de-Mesquita; E David Crawford; W Ryan Diver; Carlos A Gonzalez; J Michael Gaziano; Edward L Giovannucci; Mattias Johansson; Loic Le Marchand; Jing Ma; Sabina Sieri; Pär Stattin; Meir J Stampfer; Anne Tjonneland; Paolo Vineis; Jarmo Virtamo; Ulla Vogel; Stephanie J Weinstein; Meredith Yeager; Michael J Thun; Laurence N Kolonel; Brian E Henderson; Demetrius Albanes; Richard B Hayes; Heather Spencer Feigelson; Elio Riboli; David J Hunter; Stephen J Chanock; Christopher A Haiman; Peter Kraft
Journal:  Hum Mol Genet       Date:  2011-07-08       Impact factor: 6.150

9.  Genome-wide linkage scan of prostate cancer Gleason score and confirmation of chromosome 19q.

Authors:  Daniel J Schaid; Janet L Stanford; Shannon K McDonnell; Miia Suuriniemi; Laura McIntosh; Danielle M Karyadi; Erin E Carlson; Kerry Deutsch; Marta Janer; Lee Hood; Elaine A Ostrander
Journal:  Hum Genet       Date:  2007-05-08       Impact factor: 4.132

10.  Premature myocardial infarction novel susceptibility locus on chromosome 1P34-36 identified by genomewide linkage analysis.

Authors:  Qing Wang; Shaoqi Rao; Gong-Qing Shen; Lin Li; David J Moliterno; L Kristin Newby; William J Rogers; Ruth Cannata; Erich Zirzow; Robert C Elston; Eric J Topol
Journal:  Am J Hum Genet       Date:  2004-01-19       Impact factor: 11.025
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