PURPOSE: Pulmonary nodules may indicate the early stage of lung cancer, and the progress of lung cancer causes associated changes in the shape and number of pulmonary blood vessels. The automatic segmentation of pulmonary nodules and blood vessels is desirable for chest computer-aided diagnosis (CAD) systems. Since pulmonary nodules and blood vessels are often attached to each other, conventional nodule detection methods usually produce many false positives (FPs) in the blood vessel regions, and blood vessel segmentation methods may incorrectly segment the nodules that are attached to the blood vessels. A method to simultaneously and separately segment the pulmonary nodules and blood vessels was developed and tested. METHOD: A line structure enhancement (LSE) filter and a blob-like structure enhancement (BSE) filter were used to augment initial selection of vessel regions and nodule candidates, respectively. A front surface propagation (FSP) procedure was employed for precise segmentation of blood vessels and nodules. By employing a speed function that becomes fast at the initial vessel regions and slow at the nodule candidates to propagate the front surface, the front surface can be propagated to cover the blood vessel region with suppressed nodules. Hence, the resultant region covered by the front surface indicates pulmonary blood vessels. The lung nodule regions were finally obtained by removing the nodule candidates that are covered by the front surface. RESULT: A test data set was assembled including 20 standard-dose chest CT images obtained from a local database and 20 low-dose chest CT images obtained from lung image database consortium (LIDC). The average extraction rate of the pulmonary blood vessels was about 93%. The average TP rate of nodule detection was 95% with 9.8 FPs/case in standard-dose CT image, and 91.5% with 10.5 FPs/case in low-dose CT image, respectively. CONCLUSION: Pulmonary blood vessels and nodules segmentation method based on local intensity structure analysis and front surface propagation were developed. The method was shown to be feasible for nodule detection and vessel extraction in chest CAD.
PURPOSE: Pulmonary nodules may indicate the early stage of lung cancer, and the progress of lung cancer causes associated changes in the shape and number of pulmonary blood vessels. The automatic segmentation of pulmonary nodules and blood vessels is desirable for chest computer-aided diagnosis (CAD) systems. Since pulmonary nodules and blood vessels are often attached to each other, conventional nodule detection methods usually produce many false positives (FPs) in the blood vessel regions, and blood vessel segmentation methods may incorrectly segment the nodules that are attached to the blood vessels. A method to simultaneously and separately segment the pulmonary nodules and blood vessels was developed and tested. METHOD: A line structure enhancement (LSE) filter and a blob-like structure enhancement (BSE) filter were used to augment initial selection of vessel regions and nodule candidates, respectively. A front surface propagation (FSP) procedure was employed for precise segmentation of blood vessels and nodules. By employing a speed function that becomes fast at the initial vessel regions and slow at the nodule candidates to propagate the front surface, the front surface can be propagated to cover the blood vessel region with suppressed nodules. Hence, the resultant region covered by the front surface indicates pulmonary blood vessels. The lung nodule regions were finally obtained by removing the nodule candidates that are covered by the front surface. RESULT: A test data set was assembled including 20 standard-dose chest CT images obtained from a local database and 20 low-dose chest CT images obtained from lung image database consortium (LIDC). The average extraction rate of the pulmonary blood vessels was about 93%. The average TP rate of nodule detection was 95% with 9.8 FPs/case in standard-dose CT image, and 91.5% with 10.5 FPs/case in low-dose CT image, respectively. CONCLUSION: Pulmonary blood vessels and nodules segmentation method based on local intensity structure analysis and front surface propagation were developed. The method was shown to be feasible for nodule detection and vessel extraction in chest CAD.
Authors: Ashirwad Chowriappa; T Kesavadas; Maxim Mokin; Peter Kan; Sarthak Salunke; Sabareesh K Natarajan; Peter D Scott Journal: Int J Comput Assist Radiol Surg Date: 2012-06-13 Impact factor: 2.924
Authors: Wan Siti Halimatul Munirah Wan Ahmad; W Mimi Diyana W Zaki; Mohammad Faizal Ahmad Fauzi Journal: Biomed Eng Online Date: 2015-03-04 Impact factor: 2.819
Authors: Michael Helmberger; Michael Pienn; Martin Urschler; Peter Kullnig; Rudolf Stollberger; Gabor Kovacs; Andrea Olschewski; Horst Olschewski; Zoltán Bálint Journal: PLoS One Date: 2014-01-31 Impact factor: 3.240