Literature DB >> 21725560

Holo-Ni2+ Helicobacter pylori NikR contains four square-planar nickel-binding sites at physiological pH.

Stefano Benini1, Michele Cianci, Stefano Ciurli.   

Abstract

The crystal structure of Helicobacter pylori holo-NikR, a Ni(2+)-dependent transcription factor, determined at pH 7.3, shows four square-planar nickel-binding sites, involving one cysteinate and three histidine ligands. This observation reconciles previous inconsistencies among calorimetric data, structural information at non-physiological pH, and computational studies. This journal is © The Royal Society of Chemistry 2011

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Year:  2011        PMID： 21725560     DOI： 10.1039/c1dt11107h

Source DB:  PubMed          Journal:  Dalton Trans        ISSN： 1477-9226            Impact factor:   4.390


  9 in total

1.  Role of the N-terminus in determining metal-specific responses in the E. coli Ni- and Co-responsive metalloregulator, RcnR.

Authors:  Khadine A Higgins; Peter T Chivers; Michael J Maroney
Journal:  J Am Chem Soc       Date:  2012-04-11       Impact factor: 15.419

Review 2.  Specific metal recognition in nickel trafficking.

Authors:  Khadine A Higgins; Carolyn E Carr; Michael J Maroney
Journal:  Biochemistry       Date:  2012-09-28       Impact factor: 3.162

3.  Ni(II) coordination to mixed sites modulates DNA binding of HpNikR via a long-range effect.

Authors:  Abby L West; Sarah E Evans; Javier M González; Lester G Carter; Hiro Tsuruta; Edwin Pozharski; Sarah L J Michel
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-26       Impact factor: 11.205

4.  The Electronic Structure of the Metal Active Site Determines the Geometric Structure and Function of the Metalloregulator NikR.

Authors:  Yang Ha; Heidi Hu; Khadine Higgins; Michael Maroney; Britt Hedman; Keith Hodgson; Edward Solomon
Journal:  Biochemistry       Date:  2019-08-14       Impact factor: 3.162

5.  On the interaction of Helicobacter pylori NikR, a Ni(II)-responsive transcription factor, with the urease operator: in solution and in silico studies.

Authors:  Luca Mazzei; Olena Dobrovolska; Francesco Musiani; Barbara Zambelli; Stefano Ciurli
Journal:  J Biol Inorg Chem       Date:  2015-07-24       Impact factor: 3.358

Review 6.  Metal site occupancy and allosteric switching in bacterial metal sensor proteins.

Authors:  Alfredo J Guerra; David P Giedroc
Journal:  Arch Biochem Biophys       Date:  2011-12-08       Impact factor: 4.013

Review 7.  Nickel trafficking system responsible for urease maturation in Helicobacter pylori.

Authors:  Rui-Guang Ge; Dong-Xian Wang; Ming-Cong Hao; Xue-Song Sun
Journal:  World J Gastroenterol       Date:  2013-12-07       Impact factor: 5.742

8.  Crosstalk between the HpArsRS two-component system and HpNikR is necessary for maximal activation of urease transcription.

Authors:  Beth M Carpenter; Abby L West; Hanan Gancz; Stephanie L Servetas; Oscar Q Pich; Jeremy J Gilbreath; Daniel R Hallinger; Mark H Forsyth; D Scott Merrell; Sarah L J Michel
Journal:  Front Microbiol       Date:  2015-06-12       Impact factor: 5.640

9.  Allosteric regulation of the nickel-responsive NikR transcription factor from Helicobacter pylori.

Authors:  Karina A Baksh; Dmitry Pichugin; Robert Scott Prosser; Deborah B Zamble
Journal:  J Biol Chem       Date:  2020-11-22       Impact factor: 5.157
  9 in total

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