Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Synthesis and anti-inflammatory activity of novel biscoumarin-chalcone hybrids.

Literature DB >> 21723119

Synthesis and anti-inflammatory activity of novel biscoumarin-chalcone hybrids.

Koneni V Sashidhara¹, Manoj Kumar, Ram K Modukuri, Ravi Sonkar, Gitika Bhatia, A K Khanna, Shivika Rai, Rakesh Shukla.

Abstract

A series of synthesized novel biscoumarin-chalcone hybrids were evaluated for their anti-inflammatory and antioxidant activity. The tested compounds significantly inhibit the carrageenin induced paw oedema in albino rats and also exhibit important scavenging activities. These compounds thus constitute an interesting template for the design of new therapeutic tools against inflammation.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2011 PMID： 21723119 DOI： 10.1016/j.bmcl.2011.06.002

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

Keyword Cloud
Cited

10 in total

1. Crystal structure of (E)-1-(1-hy-droxy-naphthalen-2-yl)-3-(2,3,4-tri-meth-oxy-phen-yl)prop-2-en-1-one.

Authors: J Srividya; D Reuben Jonathan; B K Revathi; G Anbalagan
Journal: Acta Crystallogr E Crystallogr Commun Date: 2015-07-29

Review 2. Chalcone: A Privileged Structure in Medicinal Chemistry.

Authors: Chunlin Zhuang; Wen Zhang; Chunquan Sheng; Wannian Zhang; Chengguo Xing; Zhenyuan Miao
Journal: Chem Rev Date: 2017-05-10 Impact factor: 60.622

3. Ethylene glycol promoted catalyst-free pseudo three-component green synthesis of bis(coumarin)s and bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)s.

Authors: Sushama S Kauthale; Sunil U Tekale; Kavita M Jadhav; Rajendra P Pawar
Journal: Mol Divers Date: 2016-05-24 Impact factor: 2.943

Synthesis and anti-inflammatory activity of novel biscoumarin-chalcone hybrids.

1. Crystal structure of (E)-1-(1-hy-droxy-naphthalen-2-yl)-3-(2,3,4-tri-meth-oxy-phen-yl)prop-2-en-1-one.

Review 2. Chalcone: A Privileged Structure in Medicinal Chemistry.

3. Ethylene glycol promoted catalyst-free pseudo three-component green synthesis of bis(coumarin)s and bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)s.

4. Crystal structure of (E)-3-(3,4-di-meth-oxy-phen-yl)-1-(1-hy-droxy-naphthalen-2-yl)prop-2-en-1-one.

5. (E)-1-(2-Hy-droxy-6-meth-oxy-phen-yl)-3-(2,4,6-tri-meth-oxy-phen-yl)prop-2-en-1-one.

6. (2E)-1-(3,5-Di-hydroxy-phen-yl)-3-(4-meth-oxy-phen-yl)prop-2-en-1-one.

7. Synthesis and Evaluation of New Coumarin Derivatives as Antioxidant, Antimicrobial, and Anti-Inflammatory Agents.

8. (E)-1-(3,5-Di-meth-oxy-phen-yl)-3-(3-meth-oxy-phen-yl)prop-2-en-1-one.

9. (E)-1-(1-Hy-droxy-naphthalen-2-yl)-3-(2,4,5-trimeth-oxy-phen-yl)prop-2-en-1-one.

10. Synthesis, Antiviral and Cytotoxic Activity of Novel Terpenyl Hybrid Molecules Prepared by Click Chemistry.