Chunlin Zhuang1, Wen Zhang1, Chunquan Sheng1, Wannian Zhang1,2, Chengguo Xing3, Zhenyuan Miao1. 1. School of Pharmacy, Second Military Medical University , 325 Guohe Road, Shanghai 200433, China. 2. School of Pharmacy, Ningxia Medical University , 1160 Shengli Street, Yinchuan 750004, China. 3. Department of Medicinal Chemistry, College of Pharmacy, University of Florida , 1345 Center Drive, Gainesville, Florida 32610, United States.
Abstract
Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to their convenient synthesis. These natural products and synthetic compounds have shown numerous interesting biological activities with clinical potentials against various diseases. This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry. Multiple aspects of chalcone will be summarized herein, including the isolation of novel chalcone derivatives, the development of new synthetic methodologies, the evaluation of their biological properties, and the exploration of the mechanisms of action as well as target identification. This review is expected to be a comprehensive, authoritative, and critical review of the chalcone template to the chemistry community.
Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. n class="Chemical">Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to their convenient synthesis. These natural products and synthetic compounds have shown numerous interesting biological activities with clinical potentials against various diseases. This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry. Multiple aspects of chalcone will be summarized herein, including the isolation of novel chalcone derivatives, the development of new synthetic methodologies, the evaluation of their biological properties, and the exploration of the mechanisms of action as well as target identification. This review is expected to be a comprehensive, authoritative, and critical review of the chalcone template to the chemistry community.
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