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Literature DB >> 2172198

Mechanism of cell damage by ultrasound in combination with hematoporphyrin.

S Umemura¹, N Yumita, R Nishigaki, K Umemura.

Abstract

The mechanism of cell damage by ultrasound in combination with hematoporphyrin was studied. Mouse sarcoma 180 cell suspensions were exposed to ultrasound for up to 60 s in the presence and absence of hematoporphyrin, with and without active oxygen scavengers. The cell damage enhancement by hematoporphyrin was suppressed by adding histidine but not by mannitol. The enhancement was doubled in rate by substitution of deuterium oxide medium for normal water. Sonoluminescence was produced in a saline solution under similar acoustic conditions and observed to have spectral components that can excite hematoporphyrin molecules. These results suggest that cell damage enhancement is probably mediated via singlet oxygen generated by ultrasonically activated hematoporphyrin.

Entities: Chemical Disease Species

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Year: 1990 PMID： 2172198 PMCID： PMC5918111 DOI： 10.1111/j.1349-7006.1990.tb02674.x

Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050

7 in total

1. Free radical formation and cell lysis induced by ultrasound in the presence of different rare gases.

Authors: T Kondo; J Gamson; J B Mitchell; P Riesz
Journal: Int J Radiat Biol Date: 1988-12 Impact factor: 2.694

2. Photoradiation therapy. II. Cure of animal tumors with hematoporphyrin and light.

Authors: T J Dougherty; G B Grindey; R Fiel; K R Weishaupt; D G Boyle
Journal: J Natl Cancer Inst Date: 1975-07 Impact factor: 13.506

Review 3. Cancer therapy with ultrasound: a historical review.

Authors: F W Kremkau
Journal: J Clin Ultrasound Date: 1979-08 Impact factor: 0.910

4. Determination of [3H]- and [14C]hematoporphyrin derivative distribution in malignant and normal tissue.

Authors: C J Gomer; T J Dougherty
Journal: Cancer Res Date: 1979-01 Impact factor: 12.701

5. Hematoporphyrin derivative and laser photoradiation in the treatment of lung cancer.

Authors: Y Hayata; H Kato; C Konaka; J Ono; N Takizawa
Journal: Chest Date: 1982-03 Impact factor: 9.410

6. Synergistic effect of ultrasound and hematoporphyrin on sarcoma 180.

Authors: N Yumita; R Nishigaki; K Umemura; S Umemura
Journal: Jpn J Cancer Res Date: 1990-03

7. Hematoporphyrin as a sensitizer of cell-damaging effect of ultrasound.

Authors: N Yumita; R Nishigaki; K Umemura; S Umemura
Journal: Jpn J Cancer Res Date: 1989-03

7 in total

46 in total

Review 1. Section 8--clinical relevance. American Institute of Ultrasound in Medicine.

Authors:
Journal: J Ultrasound Med Date: 2000-02 Impact factor: 2.153

Review 2. Section 6--mechanical bioeffects in the presence of gas-carrier ultrasound contrast agents. American Institute of Ultrasound in Medicine.

Authors:
Journal: J Ultrasound Med Date: 2000-02 Impact factor: 2.153

Review 3. Section 7--discussion of the mechanical index and other exposure parameters. American Institute of Ultrasound in Medicine.

Authors:
Journal: J Ultrasound Med Date: 2000-02 Impact factor: 2.153

Mechanism of cell damage by ultrasound in combination with hematoporphyrin.

1. Free radical formation and cell lysis induced by ultrasound in the presence of different rare gases.

2. Photoradiation therapy. II. Cure of animal tumors with hematoporphyrin and light.

Review 3. Cancer therapy with ultrasound: a historical review.

4. Determination of [3H]- and [14C]hematoporphyrin derivative distribution in malignant and normal tissue.

5. Hematoporphyrin derivative and laser photoradiation in the treatment of lung cancer.

6. Synergistic effect of ultrasound and hematoporphyrin on sarcoma 180.

7. Hematoporphyrin as a sensitizer of cell-damaging effect of ultrasound.

Review 1. Section 8--clinical relevance. American Institute of Ultrasound in Medicine.

Review 2. Section 6--mechanical bioeffects in the presence of gas-carrier ultrasound contrast agents. American Institute of Ultrasound in Medicine.

Review 3. Section 7--discussion of the mechanical index and other exposure parameters. American Institute of Ultrasound in Medicine.

Review 4. Section 4--bioeffects in tissues with gas bodies. American Institute of Ultrasound in Medicine.

Review 5. A review of low-intensity ultrasound for cancer therapy.

6. Efficacy of chlorin e6-mediated sono-photodynamic therapy on 4T1 cells.

7. Spectrometric studies on the sonodynamic damage of protein in the presence of levofloxacin.

8. Comparing the in vivo sonodynamic effects of dual- and single-frequency ultrasound in breast adenocarcinoma.

Review 9. Stability of protein pharmaceuticals: an update.

10. Focused ultrasound-mediated sonochemical internalization: an alternative to light-based therapies.