| Literature DB >> 21718072 |
Chang Su Lim1, Goutam Masanta, Hyung Joong Kim, Ji Hee Han, Hwan Myung Kim, Bong Rae Cho.
Abstract
We report a ratiometric two-photon probe (SSH-Mito) for mitochondrial thiols. This probe shows a marked blue-to-yellow emission color change in response to RSH, a significant two-photon cross section, good mitochondrial thiol selectivity, low cytotoxicity, and insensitivity to pH over the biologically relevant pH range, allowing the direct visualization of RSH levels in live cells as well as in living tissues at 90-190 μm depth without interference from other biologically relevant species through the use of two-photon microscopy.Entities:
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Year: 2011 PMID: 21718072 DOI: 10.1021/ja205081s
Source DB: PubMed Journal: J Am Chem Soc ISSN: 0002-7863 Impact factor: 15.419