Literature DB >> 26179077

A New Turn on Fluorescent Probe for Selective Detection of Cysteine/Homocysteine.

Puhui Xie1, Guangqin Gao2, Juanjuan Liu2, Qiu Jin2, Guoyu Yang2.   

Abstract

A new fluorescent probe (probe 1) was developed for recognition of cysteine (Cys) and homocysteine (Hcy). Probe 1 exhibited a large absorption peak blue-shift (107 nm) as well as enhanced fluorescence responses to Cys/Hcy based on cyclization of thiol containing amino acids with aldehydes, inhibiting the C = N isomerization-induced quenching process by an intramolecular hydrogen bond. The detection mechanism was proved by (1)H NMR and mass spectrometry analysis.

Entities:  

Keywords:  Cys/Hcy; Fluorescent probe; Inhibiting C = N isomerization; Intramolecular hydrogen bond; Ratiometric probes

Mesh：

Substances：

Year:  2015        PMID： 26179077     DOI： 10.1007/s10895-015-1619-9

Source DB:  PubMed          Journal:  J Fluoresc        ISSN： 1053-0509            Impact factor:   2.217


  38 in total

1.  Dual-Signaling Fluorescent Chemosensors Based on Conformational Restriction and Induced Charge Transfer The authors gratefully acknowledge the National Science Foundation for support of this research (CHE-9876333) and the Departmental NMR facilities (CHE-9709183), and the UC Toxic Substances Research and Teaching Program for support of this research.

Authors:  Jesse V. Mello; Nathaniel S. Finney
Journal:  Angew Chem Int Ed Engl       Date:  2001-04-17       Impact factor: 15.336

2.  Conjugate addition/cyclization sequence enables selective and simultaneous fluorescence detection of cysteine and homocysteine.

Authors:  Xiaofeng Yang; Yixing Guo; Robert M Strongin
Journal:  Angew Chem Int Ed Engl       Date:  2011-09-20       Impact factor: 15.336

Review 3.  Fluorescent chemosensors based on spiroring-opening of xanthenes and related derivatives.

Authors:  Xiaoqiang Chen; Tuhin Pradhan; Fang Wang; Jong Seung Kim; Juyoung Yoon
Journal:  Chem Rev       Date:  2011-10-31       Impact factor: 60.622

4.  Construction of a FRET-based ratiometric fluorescent thiol probe.

Authors:  Lingliang Long; Weiying Lin; Bingbing Chen; Wensha Gao; Lin Yuan
Journal:  Chem Commun (Camb)       Date:  2010-11-12       Impact factor: 6.222

5.  Geometry relaxation-induced large Stokes shift in red-emitting borondipyrromethenes (BODIPY) and applications in fluorescent thiol probes.

Authors:  Yinghui Chen; Jianzhang Zhao; Huimin Guo; Lijuan Xie
Journal:  J Org Chem       Date:  2012-02-16       Impact factor: 4.354

6.  A highly selective fluorescent probe for detection of biological samples thiol and its application in living cells.

Authors:  Qing-Ping Zuo; Bing Li; Qi Pei; Zuojun Li; Shi-Kun Liu
Journal:  J Fluoresc       Date:  2010-05-15       Impact factor: 2.217

7.  Ratiometric fluorescence imaging of cellular glutathione.

Authors:  Gun-Joong Kim; Kiwon Lee; Hyockman Kwon; Hae-Jo Kim
Journal:  Org Lett       Date:  2011-05-06       Impact factor: 6.005

8.  Coumarin-based thiol chemosensor: synthesis, turn-on mechanism, and its biological application.

Authors:  Hyo Sung Jung; Kyoung Chul Ko; Gun-Hee Kim; Ah-Rah Lee; Yun-Cheol Na; Chulhun Kang; Jin Yong Lee; Jong Seung Kim
Journal:  Org Lett       Date:  2011-02-16       Impact factor: 6.005

9.  Hepatocyte-targeting single galactose-appended naphthalimide: a tool for intracellular thiol imaging in vivo.

Authors:  Min Hee Lee; Ji Hye Han; Pil-Seung Kwon; Sankarprasad Bhuniya; Jin Young Kim; Jonathan L Sessler; Chulhun Kang; Jong Seung Kim
Journal:  J Am Chem Soc       Date:  2012-01-03       Impact factor: 15.419

Review 10.  Structure, mechanism and regulation of peroxiredoxins.

Authors:  Zachary A Wood; Ewald Schröder; J Robin Harris; Leslie B Poole
Journal:  Trends Biochem Sci       Date:  2003-01       Impact factor: 13.807
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  2 in total

1.  Pyrazole, Imidazole, and Isoindolone Dipyrrinone Analogues: pH-Dependent Fluorophores That Red-Shift Emission Frequencies in a Basic Solution.

Authors:  Nicole Benson; Olabisi Suleiman; Samuel O Odoh; Zachary R Woydziak
Journal:  J Org Chem       Date:  2019-09-05       Impact factor: 4.354

2.  Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach.

Authors:  Nicole Benson; Adam Davis; Zachary R Woydziak
Journal:  J Vis Exp       Date:  2021-06-10       Impact factor: 1.424
  2 in total

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