Literature DB >> 21711246

Signal transduction by vascular endothelial growth factor receptors.

Sina Koch1, Sònia Tugues, Xiujuan Li, Laura Gualandi, Lena Claesson-Welsh.   

Abstract

VEGFs (vascular endothelial growth factors) control vascular development during embryogenesis and the function of blood vessels and lymphatic vessels in the adult. There are five related mammalian ligands, which act through three receptor tyrosine kinases. Signalling is modulated through neuropilins, which act as VEGF co-receptors. Heparan sulfate and integrins are also important modulators of VEGF signalling. Therapeutic agents that interfere with VEGF signalling have been developed with the aim of decreasing angiogenesis in diseases that involve tissue growth and inflammation, such as cancer. The present review will outline the current understanding and consequent biology of VEGF receptor signalling.

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Year:  2011        PMID： 21711246     DOI： 10.1042/BJ20110301

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  316 in total

1.  A combinatorial in silico and cellular approach to identify a new class of compounds that target VEGFR2 receptor tyrosine kinase activity and angiogenesis.

Authors:  J Kankanala; A M Latham; A P Johnson; S Homer-Vanniasinkam; C W G Fishwick; S Ponnambalam
Journal:  Br J Pharmacol       Date:  2012-05       Impact factor: 8.739

Review 2.  The lymphatic vasculature in disease.

Authors:  Kari Alitalo
Journal:  Nat Med       Date:  2011-11-07       Impact factor: 53.440

3.  VEGF-A engages at least three tyrosine kinases to activate PI3K/Akt.

Authors:  Guo-Xiang Ruan; Andrius Kazlauskas
Journal:  Cell Cycle       Date:  2012-06-01       Impact factor: 4.534

Review 4.  Signal transduction by vascular endothelial growth factor receptors.

Authors:  Sina Koch; Lena Claesson-Welsh
Journal:  Cold Spring Harb Perspect Med       Date:  2012-07       Impact factor: 6.915

5.  A Human Proteome Array Approach to Identifying Key Host Proteins Targeted by Toxoplasma Kinase ROP18.

Authors:  Zhaoshou Yang; Yongheng Hou; Taofang Hao; Hee-Sool Rho; Jun Wan; Yizhao Luan; Xin Gao; Jianping Yao; Aihua Pan; Zhi Xie; Jiang Qian; Wanqin Liao; Heng Zhu; Xingwang Zhou
Journal:  Mol Cell Proteomics       Date:  2017-01-13       Impact factor: 5.911

6.  Selective Imaging of VEGFR-1 and VEGFR-2 Using 89Zr-Labeled Single-Chain VEGF Mutants.

Authors:  Jan-Philip Meyer; Kimberly J Edwards; Paul Kozlowski; Marina V Backer; Joseph M Backer; Jason S Lewis
Journal:  J Nucl Med       Date:  2016-07-07       Impact factor: 10.057

7.  Profilin phosphorylation as a VEGFR effector in angiogenesis.

Authors:  Michael Simons; Martin A Schwartz
Journal:  Nat Cell Biol       Date:  2012-10       Impact factor: 28.824

8.  NRP-1 interacts with GIPC1 and α6/β4-integrins to increase YAP1/∆Np63α-dependent epidermal cancer stem cell survival.

Authors:  Daniel Grun; Gautam Adhikary; Richard L Eckert
Journal:  Oncogene       Date:  2018-05-14       Impact factor: 9.867

9.  Paxillin controls endothelial cell migration and tumor angiogenesis by altering neuropilin 2 expression.

Authors:  Alexandra E German; Tadanori Mammoto; Elisabeth Jiang; Donald E Ingber; Akiko Mammoto
Journal:  J Cell Sci       Date:  2014-02-12       Impact factor: 5.285

10.  Chemical activation and changes in surface morphology of poly(ε-caprolactone) modulate VEGF responsiveness of human endothelial cells.

Authors:  Thilo Storm; Katharina Wulf; Michael Teske; Marian Löbler; Günther Kundt; Frank Luderer; Klaus-Peter Schmitz; Katrin Sternberg; Marina Hovakimyan
Journal:  J Mater Sci Mater Med       Date:  2014-05-09       Impact factor: 3.896
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