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Literature DB >> 23033049

Profilin phosphorylation as a VEGFR effector in angiogenesis.

Abstract

Vascular endothelial growth factor (VEGF) signalling induces embryonic vascular development and angiogenesis in adult tissues. Direct phosphorylation of the actin-binding protein profilin by VEGF receptors is now shown to increase its affinity for actin, and to be essential for adult but not embryonic arteriogenesis.

Entities: Chemical Disease Gene Species

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Year: 2012 PMID： 23033049 PMCID： PMC4047563 DOI： 10.1038/ncb2596

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

15 in total

Review 1. The role of profilin complexes in cell motility and other cellular processes.

Authors: Walter Witke
Journal: Trends Cell Biol Date: 2004-08 Impact factor: 20.808

2. Silencing profilin-1 inhibits endothelial cell proliferation, migration and cord morphogenesis.

Authors: Zhijie Ding; Anja Lambrechts; Mayur Parepally; Partha Roy
Journal: J Cell Sci Date: 2006-09-12 Impact factor: 5.285

Review 3. The profile of profilins.

Authors: B M Jockusch; K Murk; M Rothkegel
Journal: Rev Physiol Biochem Pharmacol Date: 2007 Impact factor: 5.545

Review 4. Formin-binding proteins: modulators of formin-dependent actin polymerization.

Authors: Pontus Aspenström
Journal: Biochim Biophys Acta Date: 2009-07-07

Review 5. Profilin, a multi-modal regulator of neuronal plasticity.

Authors: Andreas Birbach
Journal: Bioessays Date: 2008-10 Impact factor: 4.345

Review 6. An inside view: VEGF receptor trafficking and signaling.

Authors: Michael Simons
Journal: Physiology (Bethesda) Date: 2012-08

Review 7. Signal transduction by vascular endothelial growth factor receptors.

Authors: Sina Koch; Sònia Tugues; Xiujuan Li; Laura Gualandi; Lena Claesson-Welsh
Journal: Biochem J Date: 2011-07-15 Impact factor: 3.857

8. Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis.

Authors: Yukiji Takeda; Sandra Costa; Estelle Delamarre; Carmen Roncal; Rodrigo Leite de Oliveira; Mario Leonardo Squadrito; Veronica Finisguerra; Sofie Deschoemaeker; Françoise Bruyère; Mathias Wenes; Alexander Hamm; Jens Serneels; Julie Magat; Tapan Bhattacharyya; Andrey Anisimov; Benedicte F Jordan; Kari Alitalo; Patrick Maxwell; Bernard Gallez; Zhen W Zhuang; Yoshihiko Saito; Michael Simons; Michele De Palma; Massimiliano Mazzone
Journal: Nature Date: 2011-10-09 Impact factor: 49.962

Profilin phosphorylation as a VEGFR effector in angiogenesis.

Review 1. The role of profilin complexes in cell motility and other cellular processes.

2. Silencing profilin-1 inhibits endothelial cell proliferation, migration and cord morphogenesis.

Review 3. The profile of profilins.

Review 4. Formin-binding proteins: modulators of formin-dependent actin polymerization.

Review 5. Profilin, a multi-modal regulator of neuronal plasticity.

Review 6. An inside view: VEGF receptor trafficking and signaling.

Review 7. Signal transduction by vascular endothelial growth factor receptors.

8. Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis.

Review 9. Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity.

10. Angiogenesis in platelet endothelial cell adhesion molecule-1-null mice.

Review 1. Profilin: many facets of a small protein.

Review 2. Profilin1 biology and its mutation, actin(g) in disease.

3. Profilin choreographs actin and microtubules in cells and cancer.

4. Profilin-1; a novel regulator of DNA damage response and repair machinery in keratinocytes.

Review 5. Cellular and pharmacological targets to induce coronary arteriogenesis.