Literature DB >> 2170937

A novel RNA helicase gene tightly linked to the Triplo-lethal locus of Drosophila.

D R Dorer1, A C Christensen, D H Johnson.   

Abstract

The Triplo-lethal (Tpl) locus of Drosophila is the only known locus which is lethal when present in three copies rather than the normal two. After recovering a hybrid-dysgenesis-induced mutation of Tpl we used a rapid combination of transposon tagging, chromosome microdissection and PCR to clone the P element that had transposed into the Tpl region. That P element is located within the gene for a new and unique member of the RNA helicase family. This new helicase differs from all others known by having glycine-rich repeats at both the amino and carboxyl termini. Curiously, genetic analysis shows that the P element inserted into this gene is not responsible for the Tpl mutant phenotype. We present possible explanations for these findings.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2170937      PMCID： PMC332228          DOI： 10.1093/nar/18.18.5489

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  51 in total

1.  Birth of the D-E-A-D box.

Authors:  P Linder; P F Lasko; M Ashburner; P Leroy; P J Nielsen; K Nishi; J Schnier; P P Slonimski
Journal:  Nature       Date:  1989-01-12       Impact factor: 49.962

2.  A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases.

Authors:  B Hay; L Y Jan; Y N Jan
Journal:  Cell       Date:  1988-11-18       Impact factor: 41.582

3.  Analysis of P transposable element functions in Drosophila.

Authors:  R E Karess; G M Rubin
Journal:  Cell       Date:  1984-08       Impact factor: 41.582

4.  A conserved NTP-motif in putative helicases.

Authors:  A E Gorbalenya; E V Koonin; A P Donchenko; V M Blinov
Journal:  Nature       Date:  1988-05-05       Impact factor: 49.962

5.  Mutational Events in the Triplo- and Haplo-Lethal Region (83de) of the DROSOPHILA MELANOGASTER Genome.

Authors:  R L Roehrdanz; J C Lucchesi
Journal:  Genetics       Date:  1980-06       Impact factor: 4.562

6.  Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments.

Authors:  P M Steinert; R H Rice; D R Roop; B L Trus; A C Steven
Journal:  Nature       Date:  1983-04-28       Impact factor: 49.962

7.  Mitochondrial splicing requires a protein from a novel helicase family.

Authors:  B Séraphin; M Simon; A Boulet; G Faye
Journal:  Nature       Date:  1989-01-05       Impact factor: 49.962

8.  The unusual spectrum of mutations induced by hybrid dysgenesis at the Triplo-lethal locus of Drosophila melanogaster.

Authors:  D R Dorer; A C Christensen
Journal:  Genetics       Date:  1990-08       Impact factor: 4.562

9.  Cloning of DNA sequences from the white locus of D. melanogaster by a novel and general method.

Authors:  P M Bingham; R Levis; G M Rubin
Journal:  Cell       Date:  1981-09       Impact factor: 41.582

10.  Nuclear protein p68 is an RNA-dependent ATPase.

Authors:  R D Iggo; D P Lane
Journal:  EMBO J       Date:  1989-06       Impact factor: 11.598
View more
  13 in total

1.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1990-12-25       Impact factor: 16.971

2.  Translation initiation factor 4A from Saccharomyces cerevisiae: analysis of residues conserved in the D-E-A-D family of RNA helicases.

Authors:  S R Schmid; P Linder
Journal:  Mol Cell Biol       Date:  1991-07       Impact factor: 4.272

3.  Ribosomal protein S14 is not responsible for the Minute phenotype associated with the M(1)7C locus in Drosophila melanogaster.

Authors:  D R Dorer; A Anane-Firempong; A C Christensen
Journal:  Mol Gen Genet       Date:  1991-11

4.  Characterization of a DEAD box ATPase/RNA helicase protein of Arabidopsis thaliana.

Authors:  M Okanami; T Meshi; M Iwabuchi
Journal:  Nucleic Acids Res       Date:  1998-06-01       Impact factor: 16.971

5.  p72: a human nuclear DEAD box protein highly related to p68.

Authors:  G M Lamm; S M Nicol; F V Fuller-Pace; A I Lamond
Journal:  Nucleic Acids Res       Date:  1996-10-01       Impact factor: 16.971

6.  A novel family of plant splicing factors with a Zn knuckle motif: examination of RNA binding and splicing activities.

Authors:  S Lopato; R Gattoni; G Fabini; J Stevenin; A Barta
Journal:  Plant Mol Biol       Date:  1999-03       Impact factor: 4.076

7.  Apvasa marks germ-cell migration in the parthenogenetic pea aphid Acyrthosiphon pisum (Hemiptera: Aphidoidea).

Authors:  Chun-Che Chang; Gee-Way Lin; Charles E Cook; Shwu-Bin Horng; How-Jin Lee; Ting-Yu Huang
Journal:  Dev Genes Evol       Date:  2007-02-27       Impact factor: 0.900

8.  A family of genes clustered at the Triplo-lethal locus of Drosophila melanogaster has an unusual evolutionary history and significant synteny with Anopheles gambiae.

Authors:  Douglas R Dorer; Jamie A Rudnick; Etsuko N Moriyama; Alan C Christensen
Journal:  Genetics       Date:  2003-10       Impact factor: 4.562

9.  The Triplo-lethal locus of Drosophila: reexamination of mutants and discovery of a second-site suppressor.

Authors:  D R Dorer; D H Ezekiel; A C Christensen
Journal:  Genetics       Date:  1995-11       Impact factor: 4.562

10.  Structure and expression of a cDNA encoding an RNA helicase-like protein in tobacco.

Authors:  H Itadani; M Sugita; M Sugiura
Journal:  Plant Mol Biol       Date:  1994-01       Impact factor: 4.076
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.