Literature DB >> 21708888

Human lymphoblastoid B-cell lines reprogrammed to EBV-free induced pluripotent stem cells.

Deepika Rajesh1, Sarah J Dickerson, Junying Yu, Matthew E Brown, James A Thomson, Nicholas J Seay.   

Abstract

Generation of patient-specific induced pluripotent cells (iPSCs) holds great promise for regenerative medicine. Epstein-Barr virus immortalized lymphoblastoid B-cell lines (LCLs) can be generated from a minimal amount of blood and are banked worldwide as cellular reference material for immunologic or genetic analysis of pedigreed study populations. We report the generation of iPSCs from 2 LCLs (LCL-iPSCs) via a feeder-free episomal method using a cocktail of transcription factors and small molecules. LCL-derived iPSCs exhibited normal karyotype, expressed pluripotency markers, lost oriP/EBNA-1 episomal vectors, generated teratomas, retained donor identity, and differentiated in vitro into hematopoietic, cardiac, neural, and hepatocyte-like lineages. Significantly, although the parental LCLs express viral EBNA-1 and other Epstein-Barr virus latency-related elements for their survival, their presence was not detectable in LCL-iPSCs. Thus, reprogramming LCLs could offer an unlimited source for patient-specific iPSCs.

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Year:  2011        PMID： 21708888      PMCID： PMC4081297          DOI： 10.1182/blood-2011-01-332064

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  20 in total

Review 1.  EBNA-1: a protein pivotal to latent infection by Epstein-Barr virus.

Authors:  E R Leight; B Sugden
Journal:  Rev Med Virol       Date:  2000 Mar-Apr       Impact factor: 6.989

Review 2.  Open chromatin in pluripotency and reprogramming.

Authors:  Alexandre Gaspar-Maia; Adi Alajem; Eran Meshorer; Miguel Ramalho-Santos
Journal:  Nat Rev Mol Cell Biol       Date:  2011-01       Impact factor: 94.444

3.  Transcriptional activation by EBV nuclear antigen 1 is essential for the expression of EBV's transforming genes.

Authors:  Markus Altmann; Dagmar Pich; Romana Ruiss; Jindong Wang; Bill Sugden; Wolfgang Hammerschmidt
Journal:  Proc Natl Acad Sci U S A       Date:  2006-09-11       Impact factor: 11.205

4.  Epstein-Barr virus quantitation by real-time PCR targeting multiple gene segments: a novel approach to screen for the virus in paraffin-embedded tissue and plasma.

Authors:  Julie L Ryan; Hongxin Fan; Sally L Glaser; Steven A Schichman; Nancy Raab-Traub; Margaret L Gulley
Journal:  J Mol Diagn       Date:  2004-11       Impact factor: 5.568

5.  Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells.

Authors:  Kejin Hu; Junying Yu; Kran Suknuntha; Shulan Tian; Karen Montgomery; Kyung-Dal Choi; Ron Stewart; James A Thomson; Igor I Slukvin
Journal:  Blood       Date:  2011-02-04       Impact factor: 22.113

Review 6.  Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936.

Authors:  J J M van Dongen; A W Langerak; M Brüggemann; P A S Evans; M Hummel; F L Lavender; E Delabesse; F Davi; E Schuuring; R García-Sanz; J H J M van Krieken; J Droese; D González; C Bastard; H E White; M Spaargaren; M González; A Parreira; J L Smith; G J Morgan; M Kneba; E A Macintyre
Journal:  Leukemia       Date:  2003-12       Impact factor: 11.528

7.  Induced pluripotent stem cell lines derived from human somatic cells.

Authors:  Junying Yu; Maxim A Vodyanik; Kim Smuga-Otto; Jessica Antosiewicz-Bourget; Jennifer L Frane; Shulan Tian; Jeff Nie; Gudrun A Jonsdottir; Victor Ruotti; Ron Stewart; Igor I Slukvin; James A Thomson
Journal:  Science       Date:  2007-11-20       Impact factor: 47.728

8.  Efficient feeder-free episomal reprogramming with small molecules.

Authors:  Junying Yu; Kevin Fongching Chau; Maxim A Vodyanik; Jinlan Jiang; Yong Jiang
Journal:  PLoS One       Date:  2011-03-01       Impact factor: 3.240

9.  Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures.

Authors:  Bin-Kuan Chou; Prashant Mali; Xiaosong Huang; Zhaohui Ye; Sarah N Dowey; Linda Ms Resar; Chunlin Zou; Y Alex Zhang; Jay Tong; Linzhao Cheng
Journal:  Cell Res       Date:  2011-01-18       Impact factor: 25.617

10.  The coupling of synthesis and partitioning of EBV's plasmid replicon is revealed in live cells.

Authors:  Asuka Nanbo; Arthur Sugden; Bill Sugden
Journal:  EMBO J       Date:  2007-09-13       Impact factor: 11.598
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  32 in total

Review 1.  Induced pluripotent stem cells--opportunities for disease modelling and drug discovery.

Authors:  Marica Grskovic; Ashkan Javaherian; Berta Strulovici; George Q Daley
Journal:  Nat Rev Drug Discov       Date:  2011-11-11       Impact factor: 84.694

Review 2.  Will brain cells derived from induced pluripotent stem cells or directly converted from somatic cells (iNs) be useful for schizophrenia research?

Authors:  Cheryl Filippich; Ernst J Wolvetang; Bryan J Mowry
Journal:  Schizophr Bull       Date:  2013-07-24       Impact factor: 9.306

Review 3.  Modeling heterogeneous patients with a clinical diagnosis of schizophrenia with induced pluripotent stem cells.

Authors:  Kristen J Brennand; Melissa A Landek-Salgado; Akira Sawa
Journal:  Biol Psychiatry       Date:  2013-11-15       Impact factor: 13.382

Review 4.  Promise and challenges of human iPSC-based hematologic disease modeling and treatment.

Authors:  Zhaohui Ye; Bin-Kuan Chou; Linzhao Cheng
Journal:  Int J Hematol       Date:  2012-05-23       Impact factor: 2.490

5.  Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients' responsiveness to lithium.

Authors:  S Stern; R Santos; M C Marchetto; A P D Mendes; G A Rouleau; S Biesmans; Q-W Wang; J Yao; P Charnay; A G Bang; M Alda; F H Gage
Journal:  Mol Psychiatry       Date:  2017-02-28       Impact factor: 15.992

6.  Reliable generation of induced pluripotent stem cells from human lymphoblastoid cell lines.

Authors:  Robert Barrett; Loren Ornelas; Nicole Yeager; Berhan Mandefro; Anais Sahabian; Lindsay Lenaeus; Stephan R Targan; Clive N Svendsen; Dhruv Sareen
Journal:  Stem Cells Transl Med       Date:  2014-10-08       Impact factor: 6.940

7.  Blood-derived human iPS cells generate optic vesicle-like structures with the capacity to form retinal laminae and develop synapses.

Authors:  M Joseph Phillips; Kyle A Wallace; Sarah J Dickerson; Michael J Miller; Amelia D Verhoeven; Jessica M Martin; Lynda S Wright; Wei Shen; Elizabeth E Capowski; E Ferda Percin; Enio T Perez; Xiufeng Zhong; Maria V Canto-Soler; David M Gamm
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-04-18       Impact factor: 4.799

Review 8.  Modulation of human allogeneic and syngeneic pluripotent stem cells and immunological implications for transplantation.

Authors:  S D Sackett; M E Brown; D M Tremmel; T Ellis; W J Burlingham; J S Odorico
Journal:  Transplant Rev (Orlando)       Date:  2016-02-10       Impact factor: 3.943

9.  C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells.

Authors:  Rustam Esanov; Kinsley C Belle; Marka van Blitterswijk; Veronique V Belzil; Rosa Rademakers; Dennis W Dickson; Leonard Petrucelli; Kevin B Boylan; Derek M Dykxhoorn; Joanne Wuu; Michael Benatar; Claes Wahlestedt; Zane Zeier
Journal:  Exp Neurol       Date:  2015-12-31       Impact factor: 5.330

10.  A collection of XY female cell lines.

Authors:  Fumio Kasai; Malcolm A Ferguson-Smith
Journal:  Hum Cell       Date:  2018-01-12       Impact factor: 4.174
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