Literature DB >> 16966603

Transcriptional activation by EBV nuclear antigen 1 is essential for the expression of EBV's transforming genes.

Markus Altmann1, Dagmar Pich, Romana Ruiss, Jindong Wang, Bill Sugden, Wolfgang Hammerschmidt.   

Abstract

EBV is a paradigm for human tumor viruses because, although it infects most people benignly, it also can cause a variety of cancers. Both in vivo and in vitro, EBV infects B lymphocytes in G0, induces them to become blasts, and can maintain their proliferation in cell culture or in vivo as tumors. How EBV succeeds in these contrasting cellular environments in expressing its genes that control the host has not been explained. We have genetically dissected the EBV nuclear antigen 1 (EBNA1) gene that is required for replication of the viral genome, to elucidate its possible role in the transcription of viral genes. Strikingly, EBNA1 is essential to drive transcription of EBV's transforming genes after infection of primary B lymphocytes.

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Year:  2006        PMID： 16966603      PMCID： PMC1599932          DOI： 10.1073/pnas.0605985103

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  28 in total

Review 1.  EBNA-1: a protein pivotal to latent infection by Epstein-Barr virus.

Authors:  E R Leight; B Sugden
Journal:  Rev Med Virol       Date:  2000 Mar-Apr       Impact factor: 6.989

2.  Determining the role of the Epstein-Barr virus Cp EBNA2-dependent enhancer during the establishment of latency by using mutant and wild-type viruses recovered from cottontop marmoset lymphoblastoid cell lines.

Authors:  L Yoo; S H Speck
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

3.  Promoter-proximal regulatory elements involved in oriP-EBNA1-independent and -dependent activation of the Epstein-Barr virus C promoter in B-lymphoid cell lines.

Authors:  T Nilsson; H Zetterberg; Y C Wang; L Rymo
Journal:  J Virol       Date:  2001-07       Impact factor: 5.103

4.  Essential elements of a licensed, mammalian plasmid origin of DNA synthesis.

Authors:  Jindong Wang; Scott E Lindner; Elizabeth R Leight; Bill Sugden
Journal:  Mol Cell Biol       Date:  2006-02       Impact factor: 4.272

5.  EBNA-1, a bifunctional transcriptional activator.

Authors:  Gregory Kennedy; Bill Sugden
Journal:  Mol Cell Biol       Date:  2003-10       Impact factor: 4.272

6.  Glycoprotein gp110 of Epstein-Barr virus determines viral tropism and efficiency of infection.

Authors:  B Neuhierl; R Feederle; W Hammerschmidt; H J Delecluse
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-30       Impact factor: 11.205

7.  Latent membrane protein 1 is critical for efficient growth transformation of human B cells by epstein-barr virus.

Authors:  Ulrike Dirmeier; Bernhard Neuhierl; Ellen Kilger; Gilbert Reisbach; Mark L Sandberg; Wolfgang Hammerschmidt
Journal:  Cancer Res       Date:  2003-06-01       Impact factor: 12.701

8.  The EBV nuclear antigen 1 (EBNA1) enhances B cell immortalization several thousandfold.

Authors:  Sibille Humme; Gilbert Reisbach; Regina Feederle; Henri-Jacques Delecluse; Kristine Bousset; Wolfgang Hammerschmidt; Aloys Schepers
Journal:  Proc Natl Acad Sci U S A       Date:  2003-08-28       Impact factor: 11.205

9.  Functional interaction of nuclear factor y and sp1 is required for activation of the epstein-barr virus C promoter.

Authors:  Cecilia Boreström; Henrik Zetterberg; Kristian Liff; Lars Rymo
Journal:  J Virol       Date:  2003-01       Impact factor: 5.103

10.  Maintenance of Epstein-Barr virus (EBV) oriP-based episomes requires EBV-encoded nuclear antigen-1 chromosome-binding domains, which can be replaced by high-mobility group-I or histone H1.

Authors:  S C Hung; M S Kang; E Kieff
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-06       Impact factor: 11.205
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  75 in total

1.  Chromatin profiling of Epstein-Barr virus latency control region.

Authors:  Latasha Day; Charles M Chau; Michael Nebozhyn; Andrew J Rennekamp; Michael Showe; Paul M Lieberman
Journal:  J Virol       Date:  2007-04-04       Impact factor: 5.103

Review 2.  The viral etiology of AIDS-associated malignancies.

Authors:  Peter C Angeletti; Luwen Zhang; Charles Wood
Journal:  Adv Pharmacol       Date:  2008

3.  Interaction between HMGA1a and the origin recognition complex creates site-specific replication origins.

Authors:  Andreas W Thomae; Dagmar Pich; Jan Brocher; Mark-Peter Spindler; Christian Berens; Robert Hock; Wolfgang Hammerschmidt; Aloys Schepers
Journal:  Proc Natl Acad Sci U S A       Date:  2008-01-30       Impact factor: 11.205

4.  Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survival.

Authors:  Christoph Mancao; Wolfgang Hammerschmidt
Journal:  Blood       Date:  2007-08-06       Impact factor: 22.113

5.  Autorepression of Epstein-Barr virus nuclear antigen 1 expression by inhibition of pre-mRNA processing.

Authors:  Mikio Yoshioka; Michelle M Crum; Jeffery T Sample
Journal:  J Virol       Date:  2007-12-12       Impact factor: 5.103

6.  Optimal transactivation by Epstein-Barr nuclear antigen 1 requires the UR1 and ATH1 domains.

Authors:  Gyanendra Singh; Siddhesh Aras; Arnold H Zea; Shahriar Koochekpour; Ashok Aiyar
Journal:  J Virol       Date:  2009-02-25       Impact factor: 5.103

7.  MDM2-dependent inhibition of p53 is required for Epstein-Barr virus B-cell growth transformation and infected-cell survival.

Authors:  Eleonora Forte; Micah A Luftig
Journal:  J Virol       Date:  2009-01-14       Impact factor: 5.103

8.  Epstein-Barr virus induces global changes in cellular mRNA isoform usage that are important for the maintenance of latency.

Authors:  Nicholas J Homa; Raul Salinas; Eleonora Forte; Timothy J Robinson; Mariano A Garcia-Blanco; Micah A Luftig
Journal:  J Virol       Date:  2013-09-11       Impact factor: 5.103

9.  Role for G-quadruplex RNA binding by Epstein-Barr virus nuclear antigen 1 in DNA replication and metaphase chromosome attachment.

Authors:  Julie Norseen; F Brad Johnson; Paul M Lieberman
Journal:  J Virol       Date:  2009-08-05       Impact factor: 5.103

Review 10.  Epigenetic regulation of EBV persistence and oncogenesis.

Authors:  Italo Tempera; Paul M Lieberman
Journal:  Semin Cancer Biol       Date:  2014-01-24       Impact factor: 15.707
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